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Silicate-doped hydroxyapatite and its promotive effect on bone mineralization

Frontiers of Materials Science 2013年第1期7卷 40-50页

作者： Zhi-Ye QIU In-Sup NOH Sheng-Min ZHANG Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Wuhan 430074 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Chemical and Biological Engineering Seoul National University of Science and Technology Seou1139743 Korea

bone defect is one of the most common diseases in clinic. Existing therapeutic approaches have encountered many problems, such as lack of autogenous allogeneic bone and immunological rejection to allogeneic implant. Synthetic hydroxyapatite (HA) provided solutions for bone repair, since the HA is the main inorganic component of animals’ bone. However, HA has good biocompatibility, but does not possess osteogenic capability, which is of significance for modern bone repair materials. Si is an essential trace element in bone tissue, and it has been demonstrated to be able to promote bone formation. Therefore, silicate-doped hydroxyapatite (Si-HA) may serve as a promising material for bone repair, and promote bone regeneration in the repair. The current review discusses development of Si-HA, focusing on its preparation and characterization, in vitro and in vivo evaluations of the material, positive effect of Si-HA on promoting bone formation in clinical applications, and molecular mechanism investigation of such promotive effect.

关键词： silicate-doped hydroxyapatite (Si-HA) osteogenesis collagen biosynthesis bone mineralization

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Over-processed meat and bone meal and phytase effects on broilers challenged with subclinical necrotic enteritis:Part *** mineralization and litter quality

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Animal Nutrition 2021年第1期7卷 142-151页

作者： Holy K.Zanu Sarbast K.Kheravii Natalie K.Morgan Michael R.Bedford Robert A.Swick School of Environmental and Rural Science University of New EnglandArmidaleNSW2351Australia AB Vista MarlboroughWiltshireSN84ANUnited Kingdom

This study was conducted to determine the effect of necrotic enteritis(NE),phytase level and meat and bone meal(MBM)processing on bone mineralization of broilers and litter *** 308 male broiler chicks(n=768)were allotted to 48 pens with 16 birds *** were 8 dietary treatments in a 2×2×2 factorial *** were NE challenge(no or yes),phytase level(500 or 5,000 FTU/kg),and MBM(as-received or over-processed).Half of the birds were challenged with field strains of Eimeria *** d 9 and 108 CFU per mL of Clostridium perfringens strain EHE-NE18 on d 14 and *** middle toe,tibia and femur of 2 birds per pen were excised at d 16 and 29 for determination of ash,breaking strength(BS)and bone *** d 42,all were assessed for hock burns and litter was scored and assessed for dry matter(DM).At d 16,challenged birds had lower toe ash(Pbone traits but high phytase and over-processed MBM increased bone mineral *** of hock burns may be lower under NE in-cidences due to lower livability of birds reducing litter wetness.

关键词： bone mineralization Litter quality Meat and bone meal Necrotic enteritis Phytase

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In vitro bone inducing effects of Lentinula edodes (shiitake) water extract on human osteoblastic cell cultures

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Natural Products and Bioprospecting 2013年第6期3卷 282-287页

作者： Ashraf SAIF Kristian WENDE Ulrike LINDEQUIST Al-Leith University College Umm Al-Qura UniversityMakkah 311Saudi Arabia Institute of Pharmacy Ernst-Moritz-Arndt-University GreifswaldFriedrich-Ludwig-Jahn-Straße 17D-17489 GreifswaldGermany

The effect of Lentinula edodes water extract(LE)on two osteoblastic cell cultures(HOS 58 and Saos-2)was investigated to determine if this edible medicinal mushroom has osteoinductive *** of alkaline phosphatase and mineralization were used as indicators for the vitality and maturation of the bone *** of human osteosarcoma cells HOS 58 for five days in presence of a serial dilution of the aqueous extract of ***(0.8μg/mL-125μg/mL)resulted in a significant elevation of alkaline phosphatase activity(ALP)of the cells in comparison to untreated ***-2 cells,incubated with LE(20μg/mL)andb-glycerol phosphate(2 mM)for 21 days,displayed a 2 fold level of mineralization than cells cultured soley with the positive control,*** obtained results clearly indicate the activity of LE as a bone inducing agent in ***,the shiitake mushroom(***)deserves attention as a supportive dietary treatment or nutraceutical in the case of diseases accompanied with bone disorder,such as osteoporosis,osteopenia,and late complication of diabetes.

关键词： medicinal mushrooms Lentinula edodes osteoporosis alkaline phosphatase bone mineralization shiitake

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