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Machine‐learning radiomics to predict bone marrow metastasis of neuroblastoma using magnetic resonance imaging

Cancer Innovation 2023年第5期2卷 405-415页

作者： Lin Lv Zhengtao Zhang Dongbo Zhang Qinchang Chen Yuanfang Liu Ya Qiu Wen Fu Xuntao Yin Xiong Chen Department of Urology Surgery SunYat‐Sen Memorial HospitalGuangzhouGuangdongChina Sun Yat‐Sen University of Medical School GuangzhouGuangdongChina Guangzhou Women and Children's Medical Center GuangzhouGuangdongChina Breast Tumor Center Sun Yat‐Sen Memorial HospitalGuangzhouGuangdongChina Guangdong Provincial People's Hospital GuangzhouGuangdongChina Department of Radiology Sun Yat‐Sen Memorial HospitalGuangzhouGuangdongChina Department of Radiology Guangzhou Women and Children's Medical CenterGuangzhouGuangdongChina

Background: Neuroblastoma is one common pediatric malignancy notorious forhigh temporal and spatial heterogeneities. More than half of its patients developdistant metastases involving vascularized organs, especially the bone marrow. It isthus necessary to have an economical, noninvasive method without muchradiation for follow‐ups. Radiomics has been used in many cancers to assistaccurate diagnosis but not yet in bone marrow metastasis in ***: A total of 182 patients with neuroblastoma were retrospectivelycollected and randomly divided into the training and validation sets. Fivehundredand seventy‐two radiomics features were extracted from magneticresonance imaging, among which 41 significant ones were selected via T‐testfor model development. We attempted 13 machine‐learning algorithms andeventually chose three best‐performed models. The integrative performanceevaluations are based on the area under the curves (AUCs), calibration curves,risk deciles plots, and other ***: Extreme gradient boosting, random forest (RF), and adaptiveboosting were the top three to predict bone marrow metastases in neuroblastoma while RF was the most accurate one. Its AUC was 0.90(0.86–0.93), F1 score was 0.82, sensitivity was 0.76, and negative predictivevalue was 0.79 in the training set. The values were 0.82 (0.71–0.93), 0.80,0.75, and 0.92 in the validation set, ***: Radiomics models are likely to contribute more to metastaticdiagnoses and the formulation of personalized healthcare strategies in *** has great potential of being a revolutionary method to replace traditionalinterventions in the future.

关键词： bone marrow metastasis machine learning magnetic resonance imaging neuroblastoma radiomics

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Radiomics models to predict bone marrow metastasis of neuroblastoma using CT

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Cancer Innovation 2024年第5期3卷 71-83页

作者： Xiong Chen Qinchang Chen Yuanfang Liu Ya Qiu Lin Lv Zhengtao Zhang Xuntao Yin Fangpeng Shu Department of Paediatric Urology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhouChina Department of Paediatric Surgery Guangzhou Institute of PaediatricsGuangzhou Medical UniversityGuangzhouChina Department of Pediatric Cardiology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Structural Heart DiseaseGuangzhouChina Department of Radiology Sun Yat‐sen Memorial HospitalSun Yat‐sen UniversityGuangzhouChina Department of Radiology the First People's Hospital of Kashi PrefectureKashiChina Medical School Sun Yat‐sen UniversityGuangzhouChina Department of Radiology Guangzhou Women and Children's Medical CenterGuangzhouChina

Background:bone marrow is the leading site for metastasis from neuroblastoma and affects the prognosis of patients with ***,the accurate diagnosis of bone marrow metastasis is limited by the high spatial and temporal heterogeneity of *** analysis has been applied in various cancers to build accurate diagnostic models but has not yet been applied to bone marrow metastasis of ***:We retrospectively collected information from 187 patients pathologically diagnosed with neuroblastoma and divided them into training and validation sets in a ratio of 7:3.A total of 2632 radiomics features were retrieved from venous and arterial phases of contrastenhanced computed tomography(CT),and nine machine learning approaches were used to build radiomics models,including multilayer perceptron(MLP),extreme gradient boosting,and random *** also constructed radiomics‐clinical models that combined radiomics features with clinical predictors such as age,gender,ascites,and lymph gland *** performance of the models was evaluated with receiver operating characteristics(ROC)curves,calibration curves,and risk decile ***:The MLP radiomics model yielded an area under the ROC curve(AUC)of 0.97(95%confidence interval[CI]:0.95–0.99)on the training set and 0.90(95%CI:0.82–0.95)on the validation *** radiomics‐clinical model using an MLP yielded an AUC of 0.93(95%CI:0.89–0.96)on the training set and 0.91(95%CI:0.85–0.97)on the validation ***:MLP‐based radiomics and radiomics‐clinical models can precisely predict bone marrow metastasis in patients with neuroblastoma.

关键词： bone marrow metastasis machine learning neuroblastoma radiomics

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bone marrow metastatic neuroendocrine carcinoma with unknown primary site:A case report and review of the literature

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World Journal of Clinical Cases 2022年第30期10卷 11074-11081页

作者： Xue-Bing Shi Wen-Xia Deng Feng-Xiang Jin Department of Medical Oncology Tongling People’s HospitalTongling 244000Anhui ProvinceChina Department of Hematology Tongling People’s HospitalTongling 244000Anhui ProvinceChina

BACKGROUND Metastatic neuroendocrine carcinoma(NEC) of bone marrow is ***,we report a case of bone marrow metastatic NEC with an unknown primary *** SUMMARY A 73-year-old Chinese woman was admitted to our hospital because marked chest distress and asthma lasting 1 d on March 18,*** was initially diagnosed with pulmonary infection,cardiac insufficiency,thrombocytopenia and severe *** treatment with antibiotic therapy,diuresis and blood transfusion,the patient’s symptoms greatly *** bone marrow examinations,the patient was diagnosed with bone marrow metastatic NEC,bone marrow necrosis(BMN) and secondary myelofibrosis(MF).Further imaging workup did not show the primary tumor,we presumed that the primary site might regress spontaneously or merely be unexplored due to lack of positron emission tomography with gallium ***(10 mg/d) was added to the treatment and the best supportive and symptomatic therapies were also ***,the patient’s condition continued to deteriorate and she died on May 15,*** bone marrow invasion of NEC is rare and our patient who suffered from bone marrow metastatic NEC as well as secondary BMN and MF had an extremely poor *** marrow biopsy plays an important role in the diagnosis of solid tumors invading bone marrow.

关键词： Neuroendocrine neoplasm bone marrow metastasis bone marrow necrosis Myelofibrosis Everolimus Case report

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Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification

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Cancer Communications 2019年第1期39卷 598-606页

作者： Zhi-Xia Yue Tian-Yu Xing Chao Gao Shu-Guang Liu Wen Zhao Qian Zhao Xi-Si Wang Mei Jin Xiao-Li Ma Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of PediatricsMinistry of EducationMOE Key Laboratory of Major Diseases in Children Hematology Oncology CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health56 Nanlishi RoadBeijing 100045People’s Republic of China

Background:Interphase fluorescence in situ hybridization(FISH)of bone marrow cells has been confirmed to be a direct and valid method to assess the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog(MYCN)amplification in patients with bone marrow metastatic *** amplification alone,however,is insufficient for pretreatment risk *** band 11q23 deletion has recently been included in the risk stratification of *** the present study,we aimed to evaluate the biological characteristics and prog-nostic impact of 11q23 deletion and MYCN amplification in patients with bone marrow metastatic ***:We analyzed the MYCN and 11q23 statuses of 101 patients with bone marrow metastatic neuroblastoma using interphase FISH of bone marrow *** specifically compared the biological characteristics and prognostic impact of both ***:MYCN amplification and 11q23 deletion were seen in 12(11.9%)and 40(39.6%)*** two mark-ers were mutually *** amplification occurred mainly in patients with high lactate dehydrogenase(LDH)and high neuron-specific enolase(NSE)levels(both Pbone marrow metastatic neuroblastoma patients without MYCN *** assessment of the

关键词： Neuroblastoma MYCN amplification 11q23 deletion Fluorescence in situ hybridization bone marrow metastasis Event-free survival Overall survival Neuron-specific enolase Lactate dehydrogenase

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Occult colon cancer with sepsis as the primary manifestation identified by bone marrow puncture:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2969-2975页

作者： Hua-Jun Wang Chen-Jie Zhou Department of Critical Care Medicine The Affiliated People's Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina

BACKGROUND bone marrow metastasis is common in liver and lung cancer,but there are few reports on bone marrow metastasis in colon *** date,there are no such reports from China's Mainland,and reports of bone marrow metastasis with septic shock as the main manifestation are even *** SUMMARY A 71-year-old woman with sepsis as the first symptom presented with high fever,low blood pressure and high inflammation *** tomography(CT)examination revealed mild inflammation of the lungs and no obvious abnormalities in the *** culture suggested Escherichia coli,Aeromonas hydrophila and Aeromonas caviae *** treatment significantly improved the patient’s sepsis symptoms;however,her thrombocytopenia(TCP)could not be corrected despite repeated platelet *** malignant cells were ultimately found following a bone marrow puncture smear,and further positron emission tomography/CT(PET/CT)examination confirmed that the malignant tumor in the ascending colon was accompanied by multiple metastases,including the liver and *** adenocarcinoma was confirmed by *** Patients with advanced colon cancer may not have typical clinical symptoms,and sepsis may be the first *** patients have severe TCP that cannot be explained by sepsis of intestinal origin,it is necessary to be aware of the possibility of bone marrow metastasis of intestinal *** such patients often cannot tolerate endoscopy,bone marrow biopsy smears or biopsy tests for specialized cells can help obtain a diagnosis,especially in less developed countries where PET/CT is scarce.

关键词： bone marrow metastasis Colon cancer bone marrow puncture Case report

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Esophageal squamous cell carcinoma with dural and bone marrow metastases

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World Journal of Gastroenterology 2014年第35期20卷 12691-12695页

作者： Yen-Hao Chen Cheng-Hua Huang Department of Hematology-Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Patients with esophageal squamous cell carcinoma generally present at an advanced stage at the time of *** most common sites of visceral metastasis are the lung,liver and bone,but brain and bone marrow involvement is exceedingly ***,we report a 62-year-old man with a 4-wk history of progressive low back pain with radiation to bilateral lower legs,dysphagia and body weight *** squamous cell carcinoma with regional lymph node,liver and bone metastases was *** underwent concurrent chemoradiotherapy and got a partial *** months later,he complained of headache,diplopia and severe hearing impairment in the left *** was no evidence for bacterial,fungal,tuberculous infection or neoplastic *** resonance imaging of the brain demonstrated thickening and enhancement of bilateral pachymeninges and multiple enhancing masses in bilateral *** metastasis was diagnosed and he received whole brain *** addition,laboratory examination revealed severe thrombocytopenia and leucopenia,and bone marrow study confirmed the diagnosis of metastatic squamous cell *** is the first described case of esophageal squamous cell carcinoma with dural and bone marrow *** also discuss the pathogenesis of unusual metastatic diseases and differential diagnosis of pachymeningeal thickening.

关键词： Esophageal cancer Squamous cell carcinoma Dural metastasis bone marrow metastasis

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Thrombocytopenia with multiple splenic lesions-histiocytic sarcoma of the spleen without splenomegaly: A case report

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World Journal of Clinical Oncology 2020年第3期11卷 162-168页

作者： Kai Huang Alvaro Frometa Columbie Robert W Allan Subhasis Misra Department of General Surgery Brandon Regional HospitalHCA West Florida Division/USF ConsortiumBrandonFL 33511United States Department of Pathology and Laboratory Medicine Brandon Regional HospitalUniversity of South FloridaHCA West Florida DivisionBrandonFL 33511United States Chief Pathology and Laboratory Medicine Service North Florida and Southern Georgia VA SystemClinical Professor of PathologyUniversity of FloridaGainesvilleFL 32611United States

BACKGROUND Histiocytic sarcoma(HS)of the spleen is reported to be a rare and lethal *** clinicopathological features of splenic HS have not been well *** objective of this paper is to describe the diagnosis and treatment of a case of this rare disease and provide a review of the *** SUMMARY In this article,we discuss the case of a 40-year-old Hispanic female who presented with progressive thrombocytopenia and multiple hypoechoic lesions in the spleen without *** emission tomography-computed tomography showed increased activity in cervical lymph nodes,as well as multiple bone and splenic lesions with positive *** bone marrow biopsies and fine-needle aspiration of the cervical lymph node were *** splenectomy was performed,and gross examination showed a 110.1 g spleen with multiple rubbery,nodular lesions within the subcapsular sinus and splenic *** microscopic findings showed multinodular histiocyte proliferation with atypia and multilobulated nuclei,which were positive for CD163,CD4,and CD68 by immunohistochemical *** final pathologic diagnosis was difficult and was found to be low-grade HS of the spleen,after consultations with two renowned hematopathology *** the patient’s five-month follow-up visit,her bone marrow metastasis had *** is waiting to be enrolled in a clinical *** Pathologic diagnosis of splenic HS can be ***-grade differentiation may be associated with a slow progressive disease.

关键词： Histiocytic sarcoma Spleen Proliferation Thrombocytopenia bone marrow metastasis Case report

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