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Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao Yongjia Song Minghui Hang Hao Xu Qiang Li Pengyu Wang Tao Chen Mengxiong Xia Qi Shi Yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

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Fibrous hamartoma of infancy with bone destruction of the tibia:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11190-11197页

作者： Yong-Jie Qiao Wen-Bin Yang Yan-Feng Chang Hao-Qiang Zhang Xin-Yuan Yu Sheng-Hu Zhou Yan-Yan Yang Lv-Dan Zhang Department of Joint Surgery The 940th Hospital of Joint Logistic Support Force of the Chinese People's Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Orthopedics The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Cardiology Yongjing County People's Hospital of Gansu ProvinceLanzhou 730050Gansu ProvinceChina Department of Respiratory Medicine The 940th Hospital of Joint Logistic Support Force of the Chinese People's Liberation ArmyLanzhou 730050Gansu ProvinceChina

BACKGROUND Fibrous hamartoma of infancy(FHI)is a rare disease of infancy with unknown *** disease mainly involves soft tissue,has no specific clinical manifestations,and is difficult to *** present,the diagnosis is mainly confirmed by histopathological examination,and the main treatment is surgical resection of the pathological tissue,which is prone to *** SUMMARY A five-month-old female patient was admitted to our hospital with swelling in the right *** biopsies were performed in our hospital and another hospital,respectively,confirming the diagnosis as fibrous *** exclusion of surgical contraindications,resection was performed with clear margins of 1 *** examination showed tumor recurrence more than four months after the operation,and surgery was performed again to extend the resection margins to 1.5 *** patient is recovering well,and after a follow-up of 36 mo,shows no signs of *** Our case report demonstrates that FHI should be considered in the differential diagnosis for a lower extremity mass with bone *** FHI with bone destruction and unclear boundaries,excision margins of 1.5 cm could be superior to margins of 1 cm.

关键词： Infant Tibia Fibrous hamartoma bone destruction Case report

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Effect of Sangu Decoction(三骨汤) on Metastatic bone destruction in Rats with Mammary Cancer

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Chinese Journal of Integrative Medicine 2012年第4期18卷 304-307页

作者：邓博贾立群高福云崔建李环 Department of Chinese Medicine on Tumor China-Japan Friendship Hospital Beijing University of Chinese Medicine

Objective： To study and evaluate the effect of Sangu Decoction （SGD, 三骨汤） on the bone destruction due to mammary cancer metastasis. Methods： Metastasis rat mammary tumor-1 cells were transplanted into the left hind limb tibia of SD rats to establish the bone metastasis of the mammary cancer model. The modeled rats were treated with SGD for observing its effect on rats＇ pain behavior, including 50% paw withdrawal threshold （50% PWT） after von Frey fiber stimulation, burden difference of bilateral feet, and thermal withdrawal latency （TWL）, with zoledronic acid as the positive control. Moreover, the damage in the tibia sample of rats was scored by an iconographic method, and the bone mineral density （BMD） as well as the bone mineral content （BMC） were estimated. Results： The model established showed characteristics of mixed metastasis, revealing the manifestations of tumor development, bone destruction, cancerous pain, etc. In the SGD-treated group, 50% PWT was prolonged （8.13±4.76 vs. 2.30±2.19）, and TWL was longer （3.48±0.62 s vs. 2.89± 0.26 s） than those in the control group, respectively （P〈0.05 or P〈0.01）. Iconographic scoring also showed improvement of BMD （0.134±0.009 vs. 0.120±0.007, P〈0.01） and an elevating trend of BMC in the SGD-treated group. Conclusion： SGD could effectively alleviate the cancerous pain of bone metastasis and mitigate the metastasis that cause osteolytic destruction of bone.

关键词： cancerous pain metastasis of mammary cancer Chinese medicine therapy bone destruction

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Clinical characteristics and risk factors of Talaromyces marneffei infection in human immunodeficiency virus-negative patients: A retrospective observational study

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World Journal of Emergency Medicine 2021年第4期12卷 281-286页

作者： Hong-yan Wei Wen-jie Liang Bin Li Ling-yu Wei An-qi Jiang Wei-dong Chen Peng-hao Guo Jia Xu Department of Emergency Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Pulmonary and Critical Care Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Clinical Trial Unit the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

BACKGROUND: To investigate the clinical characteristics and risk factors of human immunodeficiency virus(HIV)-negative patients with Talaromyces marneffei(T. marneffei) ***: We retrospectively collected the clinical information of HIV-negative patients with T. marneffei infection from January 1, 2010 to June 30, 2019, and analyzed the related risk factors of poor ***: Twenty-five cases aging 22 to 79 years were included. Manifestations of T. marneffei infection included fever, cough, dyspnea, chest pain or distress, lymphadenopathy, ear, nose, and throat(ENT) and/or skin lesions, bone or joint pain, edema and pain in the lower extremities, digestive symptoms, icterus, malaise, and hoarseness. Two cases had no comorbidity, while 23 cases suff ered from autoimmune disease, pulmonary disease, cancer, and other chronic diseases. Sixteen cases had a medication history of glucocorticoids, chemotherapy or immunosuppressors. Pulmonary lesions included interstitial infiltration, nodules, atelectasis, cavitary lesions, pleural effusion or hydropneumothorax, bronchiectasis, pulmonary fibrosis, pulmonary edema, and consolidation. The incidence of osteolytic lesions was 20%. Eight patients received antifungal monotherapy, and 11 patients received combined antifungal agents. Fifteen patients survived and ten patients were dead. The Cox regression analysis showed that reduced eosinophil counts, higher levels of blood urea nitrogen(BUN), alanine aminotransferase(ALT), aspartate aminotransferase(AST), lactic dehydrogenase(LDH), myoglobin(Mb), procalcitonin(PCT), and galactomannan were related to poor prognosis(hazard ratio [HR]>1, Pbone destruction is common in HIV-negative patients with T. marneffei infection. Defective cell-mediated immunity, active infection, multiple system, and organ damage can be the risk factors of poor prognosis.

关键词： Talaromyces marneffei Human immunodeficiency virus bone destruction Risk factors

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New perspectives on traumatic bone infections

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Chinese Journal of Traumatology 2020年第6期23卷 314-318页

作者： Ruo-Hui Tang Jing Yang Jun Fei Health Team of 96824 Troops of the Chinese People's Liberation Army KunmingChina Emergency Department Daping HospitalThird Military Medical UniversityChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqingChina

In this paper,we review the results of previous studies and summarize the effects of various factors on the regulation of bone metabolism in traumatic bone ***-related bone destruction incorporates pathogens and iatrogenic factors in the process of bone resorption dominated by the skeletal and immune *** development of bone immunology has established a bridge of communication between the skeletal system and the immune *** the effects of pathogens,skeletal systems,immune systems,and antibacterials on bone repair in infectious conditions can help improve the treatment of these diseases.

关键词： bone infection bone destruction Osteoclasts Immunomodulation

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A One-year Evaluation of Radiographic Progression in Patients with Rheumatoid Arthritis Treated by Qingre Huoxue Decoction(清热活血方)

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Chinese Journal of Integrative Medicine 2012年第4期18卷 256-261页

作者：姜泉周新尧王雷余卫汪平曹炜唐晓颇 School of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine Department of Rheumatology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Department of Radiology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Department of Radiology Beijing Union Hospital

Objective： TO investigate the effects of Qingre Huoxue Decoction （清热活血方, clearing heat and promoting blood flow; QRHXD）, on the radiographic progression in patients with rheumatoid arthritis （RA） by X-ray imaging. Methods： Eighty-six patients with active RA diagnosed as damp-heat and blood stasis syndrome were randomized into a QRHXD group and a QRHXD plus methotrexate （MTX） group, with 43 cases in each group. After one-year of treatment, 21 cases in each group （42 in total） were evaluated. Radiographs of hands were obtained at the baseline and after 12 months of treatment. Images were evaluated by investigators blinded to chronology and clinical data, and assessed according to the SharpNan der Heijde methods. Results： High intrareader agreements were reached （mean intraobserver intraclass coefficients： 0.95）. No significant change in any imaging parameters of joint destruction was observed at 12 months in either group; and the differences between the two groups were not significant （P〉0.05）. The mean of the changing score in the QRHXD group was 3.5 ± 4.1, and 2.4 ± 3.5 in the QRHXD＋MTX group, while the baseline radiographic score of patients in the QRHXD group was relatively higher （18.9± 19.1 vs. 14.0± 14.0）. The mean rates of the changing scores of the two groups were similar （0.24 ± 0.28 vs. 0.25± 0.44, P=0.40）. The severity of progression in the two groups was also similar （P=0.46）, 7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD＋MTX group, 3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD＋MTX group. Conclusion： Radiographic progression of RA patients in both groups is similar, indicating that the QRHXD Decoction has a potential role in preventing bone destruction.

关键词： rheumatoid arthritis Qingre Huoxue Decoction Chinese medicine herb radiology bone destruction

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Aneurysmal bone cyst of the maxilla rare presentation with radiological and pathological correlation

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Plastic and Aesthetic Research 2015年第1期2卷 73-75页

作者： Bharat Bhushan Sharma Priya Ramchandran Sandeep Sharma Shweta Sharma Department of Radio Diagnosis PGIMER and Dr.RML HospitalNew Delhi 110001India Intensive Care Unit and Anesthesiology Heartlands HospitalB912AFBriminghamUK Pain Management and Anesthesiology SGT Medical College Gurgaon 122505HaryanaIndia ENT and Head and Neck Surgery PGIMER and Dr.RML HospitalNew Delhi 110001India

The incidence of aneurysmal bone cyst in the maxillofacial region is rare and may remain undiagnosed for a long period prior to becoming *** may cause associated issues secondary to compression by extending to the surrounding vital anatomical *** aggressive course can lead to bony destruction with intracranial *** present a case of a 23-year-old man who presented with bilateral exorbitism with nasal obstruction.

关键词： Aggressive course aneurysmal bone cyst bone destruction intracranial extension

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Depleting carboxy-terminals in human Wnt5a vaccines attenuates collagen-induced arthritis in DBA/1 mice

Depleting carboxy-terminals in human Wnt5a vaccines attenuat...

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第十二届全国免疫学学术大会

作者： yuan huihui Cao Wei Zhao Wenming Department of Immunology School of Basic Medical SciencesCapital Medical University

Objective:Wnt5a signalling plays important roles in regulating bone homeostasis and immune *** detected the immunogenic and anti-rheumatic effects of different hWnt5a-based DNA vaccines in a collagen-induced arthritis... 详细信息

关键词： Wnt5a DNA vaccines Rheumatoid arthritis bone destruction

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