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Determination of creatinine level in patient blood samples by Fourier NIR spectroscopy and multivariate analysis in comparison with biochemical assay

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Journal of Innovative Optical Health Sciences 2019年第6期12卷 46-55页

作者： Zvi Hai Barnea(Burbea) David Abookasis Nephrology Department Edith Wolfson Hospital Holon 5822012Israel Sackler Faculty of Medicine Tel Aviv University Ramat Aviv 6997801Israel Department of Electrical and Electronics Engineering Ariel University Ariel 4070000Israel

In this paper,in vivo spectra from 23 patients'blood samples with various Creatinine(Cr)concentration levels ranging from 0.96 to 12.5 mg/dL were measured using Fourier transform near-infrared spectrometer(FT-NIRS)and spectrum quantitative analysis *** Cr undergoes passive filtration,it serves as a key biomarker of kidneys function via the estimation of glomerular filtration ***,increased blood Cr concentration reflects impaired renal *** spectra pre processing and outlier exclusion,a spectral model was developed based on partial least squares regression(PLSR)method,wherein Cr concentrations correlated with filtered NIR spectra across several peaks,where Cr is know n to absorb NIR *** statistical metrics were applied to estimate the model efficiency during data *** of spectra-derived concentrations to reference Cr measurements by the current gold-standard Jaffe's method held in hospital lab revealed a Cr prediction accuracy of 1.64 mg/dL with good corre-lation of R=***-Altman plots were used to compare between our calculations and ref-erence lab values and reveal minimal bias between the *** finding presented the potential of FT-NIRS coupled with PLSR technique for Cr determination.

关键词： Creatinine Fourier transform near infrared spectroscopy blood samples chemo metrics statistical analysis

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Isolation of Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) <i>Salmonella typhi</i>from blood samples of Patients Attending Tertiary Medical Centre in Dhaka City, Bangladesh

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Advances in Microbiology 2021年第9期11卷 488-498页

作者： Oshin Ghurnee Amit Kumar Ghosh Maruf Abony Shahrin Akhter Aurin Aneeka Nawar Fatema Avijit Banik Zakaria Ahmed Department of Microbiology Primeasia University Dhaka Bangladesh Microbiology Department Technology Wing Bangladesh Jute Research Institute Dhaka Bangladesh

Objective: Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance Salmonella typhi in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal Salmonella typhi among the patients attending a tertiary medical center by conventional culture and serologic test. Materials and Methods: blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation Salmonella strains were identified and were tested for antibiotic resistance. Results: A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as Salmonella typhi. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. Discussion: It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). Conclusion: The emergence of XDR and MDR strains of S. typhi in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later.

关键词： MDR XDR S. typhi blood samples Typhoid Fever Bangladesh

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Magnetic covalent organic framework nanospheres-based miRNA biosensor for sensitive glioma detection

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Bioactive Materials 2022年第8期7卷 145-151页

作者： Dong Liang Xiaoyi Zhang Yi Wang Taotao Huo Min Qian Yibo Xie Wenshuai Li Yunqiu Yu Wei Shi Qianqian Liu Junle Zhu Chun Luo Zhijuan Cao Rongqin Huang School of Pharmacy Key Laboratory of Smart Drug DeliveryMinistry of EducationFudan UniversityShanghai201203China Center for Advanced Low-dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201600China Department of Neurosurgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Neurosurgery Tongji HospitalTongji University School of MedicineShanghai200065China

Sensitive detection and accurate diagnosis/prognosis of glioma remain urgent ***,dispersed magnetic covalent organic framework nanospheres(MCOF)with uniformed Fe3O4 nano-assembly as cores and high-crystalline COF as shells were prepared by monomer-mediated in-situ interface growth *** on the unique interaction between MCOF and hairpin DNA,a fluorescent signal amplified miRNA biosensor was *** could realize the sensitive detection of miRNA-182 in different matrixes,where the detection limit,linearity range and determination coefficient(R^(2))in real blood samples reached 20 fM,0.1 pM-10 pM and 0.991,***,it possessed good stability and precision as observed from the low intra-day/inter-day RSD and high extraction *** a result,it could quantify miRNA-182 in serum of glioma patients,the concentration of which was significantly higher than that of healthy people and obviously decreased after ***,a proof-of-concept capillary chip system using this biosensor was proposed to realize the visualized detection of miRNA-182 in *** findings suggest a robust way for sensitive detection and accurate diagnosis/prognosis of glioma.

关键词： blood samples Fluorescence signal amplification biosensor Glioma diagnosis Magnetic COF nanospheres miRNA detection

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