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Effects of plasma ghrelin, obestatin, and ghrelin/obestatin ratio on blood pressure circadian rhythms in patients with obstructive sleep apnea syndrome

引用

Chinese Medical Journal 2014年第5期127卷 850-855页

作者： Liu Weiying Yue Hongmei Zhang Jiabin Pu Jiayuan Yu Qin Department of Respiratory Medicine First Hospital of Lanzhou University Lanzhou Gansu 730000 China

Background Obstructive sleep apnea syndrome （OSAS） is strongly associated with obesity and with cardiovascular *** and obestatin are two peptides from the same source but have opposite *** of them can affect feeding and regulate vascular *** aim of this study was to investigate the relationship between plasma ghrelin,obestatin,the ratio of ghrelin and obestatin （G/O） and sleep parameters and blood pressure circadian rhythms in patients with *** This study enrolled 95 newly diagnosed over-weight OSAS patients （OSAS group）,30 body mass index （BMI）-match non-OSAS adults （over-weight group） and 30 non-OSAS normal weight adults （control group）.Polysomnography （PSG） was performed in the OSAS group and over-weight *** pressure of all subjects was monitored by means of 24-hour ambulatory blood pressure *** concentration of plasma ghrelin and obestatin was detected by enzyme-linked immunosorbent assay （ELISA）.Results Plasma ghrelin levels in the OSAS group and over-weight group were significantly lower than that of the control group （P ＜0.05）.Plasma obestatin levels were lower in the over-weight group and OSAS group,but there was no significant difference among the three *** blood pressure in OSAS patients was higher,and there was a significant difference in all blood pressure parameters compared to the control group,and in the daytime average diastolic blood pressure （DBP）,nocturnal average systolic blood pressure （SBP） and DBP,DBP variability values as compared to over-weight ***,there were significantly more non-dipper patterns of blood pressure （including hypertension and normotension） in the OSAS group than in the other two groups （P ＜0.01）.Correlation analysis showed that ghrelin levels had a significant correlation with BMI and nocturnal average DBP but not with PSG *** contrast,the G/O ratio had a negative correlation with apnea-hypopnea index （AHI）（P ＜0.05）,as well as a strong pos

关键词： obstructive sleep apnea syndrome ghrelin obestatin ghrelin/obestatin ratio blood pressure circadian rhythms

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