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blood lead levels among children aged 0 to 6 years in 16 cities of China, 2004-2008

Chinese Medical Journal 2013年第12期126卷 2291-2295页

作者： XIE Xiao-hua TAN Zang-wen JIA Ni FAN Zhao-yang ZHANG Shuai-ming Lu Yan-yu CHEN Li DAI Yao-hua Department of Integrated Early Childhood Development Capital Institute of Paediatrics Beijing 100020 China

Background The adverse health effects of lead for children under 6 years are well *** to assess the lead exposure among children in China are small in sample size and lack of national representative *** aim of this study therefore was to describe blood lead levels and identify risk factors for lead exposure among children aged 0 to 6 years living in 16 cities in *** We analyzed data from blood lead levels surveillance in China carried out in 16 large cities between 2004 and 2008.A stratified clustered random sampling strategy was used.A total of 69 968 children aged 0 to 6 years were *** conducted multiple Logistic regression analyses to explore risk factors to high blood lead *** The geometric mean blood lead level of the children was 4.50 μg/dl （median：4.90 μg/dl; IQR：3.20-7.00 μg/dl）.Overall prevalence of blood lead level ≥10.00 μg/dl among 0-to 6-year-old children was 7.57%.But the proportion of blood lead level ≥5.00 but 〈10.00 μg/dl was 42.12%.blood lead levels were significantly higher in boys （4.63 μg/dl） than in girls （4.35 μg/dl）（P 〈0.0001）.The geometric mean blood lead levels and prevalence of blood lead level ≥10.00 μg/dl increased with age （P 〈0.0001 for the two trends）.After controlling for sociodemographic,dietary and behavior factors,multivariable analysis indicated that lower maternal education,male gender,younger age,often biting pencil or/and toys,walking or playing for long time on the street,not washing hands before eating are major risk factors for higher lead *** The blood lead levels among Chinese children in urban areas are lower than previous studies but close to those of developed ***,children with low lead exposure account for almost half and the sociodemographic factors （age,male sex,and low mother education level） continue to be associated with higher blood lead levels.

关键词： children lead poisoning blood lead risk factors

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Effects of Environmental lead Pollution on blood lead and Sex Hormone Levels among Occupationally Exposed Group in An E-waste Dismantling Area

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Biomedical and Environmental Sciences 2013年第6期26卷 474-484页

作者： YANG Yan LU Xiao Song LI Ding Long YU Yun Jiang School of Environmental & Safety Engineering Changzhou University South China Institute of Environmental Sciences.MEP

Objective To study the effects of environmental multi-media lead pollution on blood lead and sex hormone levels among lead exposed males engaged in E-waste dismantling, and the correlation between confounding factors and sex hormone levels. Methods An E-waste dismantling area in Taizhou of Zhejiang Province was selected as the research site. One hundred and fifty two samples were collected from the groundwater, soil, rice, corn, chicken, and pork in the dismantling area. The effects of the multi-media lead pollution on the male blood lead and sex hormone levels of FSH, LH, and T, as well as the correlation with confounding factors, were studied. Results The blood lead concentrations in the males aged under 31, from 31 to 45 and from 46 to 60 were 98.55, 100.23, and 101.45 I~/L, respectively. Of all the environmental media lead exposures, the groundwater, rice and soil were main contributing factors to the lead accumulation in humans. FSH and LH levels increased with the age while the T levels decreased with the age instead. There was a significant correlation between the FSH and LH levels and wearing masks. Conclusion There was correlation between the FSH, LH, and T levels, and the mean values of lead concentrations in environmental media, and the sex hormone levels were correlated with the confounding factor of wearing masks.

关键词： lead E-waste dismantling Follicle stimulating hormone (FSH) Luteinizing hormone (LH) Testosterone (T) blood lead

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Hypertension Control in the Presence of High blood lead Level

Hypertension Control in the Presence of High Blood Lead Leve...

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2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Jia Wei John S.Ji Environmental Research Center Duke Kunshan University

Objectives Hypertension affects more than 30%of US ***-hypertensive medication is prescribed to control blood *** to lead,as a heavy metal,can increase blood pressure through oxidative stress,activity of angiotensin-converting en2 yme,and endothelial *** study has examined hypertensive control in the presence of high blood *** We used nationally representative data,US National Health and Nutrition Examination Survey(NHANES),from 1999 to *** pressure was measured in people aged 16 years and *** was identified in participants defined as systolic blood pressure(SBP) ≥140 mm Hg,diastolic blood pressure(DBP) ≥ 90 mm Hg(pre-2017 guidelines),or self-reported hypertension diagnosis,or use of anti-hypertensive ***-hypertensive medications studied included:beta-blockers,calcium channel blockers,diuretics,angiotensin converting enzyme inhibitors,angiotensin receptor blockers,and *** linear regression models adjusted for age,sex,race,education,and income were used to estimate the interaction between blood pressure,blood lead level,and anti-hypertensive *** blood lead level was defined as ≥ 5 ug/dL by CDC *** We estimated 37.1%of Americans have high blood pressure or hypertension,and 63.4%of those with high blood pressure were taking one or more anti-hypertensive medications.A total of 16895 participants with hypertension and blood lead measurements were included in the *** mean(SE) SBP/DBP was134.0(0.26)/73.8(0.23) *** weighted mean(SE) value of blood lead was1.95(0.02) ug/dL.5.6%of our population had lead concentrations that exceeded CDC guideline of ≥ 5 ug/*** lead levels independently led to higher SBP/DBP by1.14 mm Hg(95%CI:0.63 to 1.64,***)/0.87 mm Hg(95%CI:0.53 to 1.14,***).Anti-hypertensive medication reduced SBP/DBP by 10.41 mmHg(95%CI:9.09 to 11.72,***)/3.68 mmHg(95%CI:2.77 to 4.60,***).Among people with blood le

关键词： Hypertension blood lead Treatment

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Environmental Exposure to lead as a Risk for Prostate Cancer

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Biomedical and Environmental Sciences 2002年第4期15卷 298-305页

作者： M．K．J．SIDDIQUI S．SRIVASTAVA 等 IndustialToxicologyReserachCentre PostBoxNo.80.M.G.Marg.Lucknow226－001India Dr RMLAvadhUniversityFaizabad－224001India

Objective To evaluate the possible role of environmental exposure to lead as a risk factor for prostate pathology in patients suffering from prostate cancer (PCA) and benign prostate hyperplasia (BPH). Methods blood lead (BPb) level was determined in PCA and BPH cases using a graphite furnace Atomic Absorption Spectrophotometer and compared with those in a control group living in the similar socioeconomic environment. Results BPb was significantly higher in PCA and BPH cases than in normals (Pblood levels of zinc and copper were significantly lower in PCA and BPH cases when compared with controls (Plead and thiobarbituric acid reactive substances (TEARS) measured as malondialdehyde, and negative correlation between blood lead and antioxidant GSH level, indicative of possible generation of reactive oxygen species, were also observed after adjusting for age as a possible confounders. However, positive association between blood lead and TEARS was relatively higher in PCA patients (r=0.77, Plead may be a risk factor for prostate cancer and/or benign prostate hyperplasia possibly through generation of reactive oxygen species and/or reducing the level of zinc which acts as a cellular growth protector.

关键词： Benign prostate hyperplasia Prostate cancer blood lead Atomic Absorption Spectrophotometer

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Assessment of lead Exposures during Abrasive Blasting and Vacuuming in Ventilated Field Containments: A Case Study

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Occupational Diseases and Environmental Medicine 2022年第2期10卷 116-131页

作者： Kevin Guth Marie Bourgeois Raymond Harbison Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Painting contractors have struggled with implementation and assessment of lead exposure controls leading to persistently elevated blood lead levels in this high-risk group of workers. The objective of this study was to assess the intensity of lead exposures based on commonly used air velocities inside field containment structures during abrasive blasting and vacuuming. Exposures were assessed over 14 days from April to July 2021 at a tainter gate and bridge lead paint removal project. Personal air samples, skin wipes, air velocity readings, and blood lead samples were collected. The geometric mean (GM) lead exposure for abrasive blasters and vacuumers was ≥4 × the OSHA lead Permissible Exposure Limit (PEL) of 50 μg/m3. There was high variability in the personal lead exposures (Geometric standard deviation (GSD) 4.0 - 5.0). The GM hand wipe exposures exceeded a Dermal PEL of 500 μg/wipe (abrasive blaster 564 μg/wipe and vacuumer 754 μg/wipe). Residual lead was measured on workers’ hands in 67% of the post hand washing samples. Air velocities measured inside of the field containments ranged from 107 feet per minute to 229 feet per minute. The effect of air velocity on the concentration of lead on workers’ hands after work (F = 0.58, p = 0.35) and airborne lead concentration was not significant (F = 0.36, p = 0.48). Six of the eight workers’ blood lead levels increased after exposure to lead. There was a non-statistically significant relationship between lead remaining on workers’ hands after handwashing and an increase in blood lead level. This is the first study that assessed both ventilation flow rates used in the industrial painting industry and measurements of airborne and dermal (hands) lead exposures. For the projects evaluated, the collected exposure data indicate that air velocities frequently used in the industrial painting industry to ventilate field containment structures did not tend to prevent an increase in worker blood lead and were ineffecti

关键词： Occupational lead Exposure blood lead Engineering/Work Practice Controls

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Health risk assessment of lead pollution in inner-city environment in Shenyang, China

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Acta Geochimica 2006年第S1期 56-56页

作者： Huimin REN1,2, Jinda WANG1, Xuelin ZHANG1 1 Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences 2 Graduate School of Chinese Academy of Sciences

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