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Journal of Innovative Optical Health Sciences 2024年第1期17卷 61-68页

作者： Hui Cheng Jincheng Zhong Ping Qiu Ke Wang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P.R.China

Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.

关键词： 1700 nm-Window third-harmonic generation imaging blood flow velocity

RETINAL SPECTRAL IMAGING AND blood flow MEASUREMENT

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 255-265页

作者： PAUL LEMAILLET DONALD D.DUNCAN ART LOMPADO MOHAMED IBRAHIM QUAN DONG NGUYEN JESSICA C.RAMELLA-ROMAN Department of Biomedical Engineering The Catholic University of America 620 Michigan Ave. N.E.WashingtonDC 20064USA ECE Department Portland State University 1900 SW Fourth AvenuePortlandOR 97201USA Polaris Sensor Technologies 200 Westside Square Suite 320 HuntsvilleAL 35801USA Wilmer Eye Institute Johns Hopkins University BaltimoreMD 21287USA

Measurement of both oxygen saturation and blood flow in the retinal vessels has proved to give important information about the eye health and the onset of eye pathologies such as diabetic retinopathy.In this study,we present the implementation,on a commercially available fundus camera,of a retinal imager and a retina blood flow velocimeter.The retinal imager uses division of aperture to acquire nine wavelength-dependent sub-images of the retina.Careful consideration is taken to improve image transfer by measuring the optical properties of the fundus camera and modeling the optical train in Zemax.This part of the setup is calibrated with optical phantoms of known optical properties that are also used to build a lookup table(LUT)linking phantom optical properties to measured reflectance.The retina blood flow velocimeter relies on tracking clusters of erythrocytes and uses a fast acquisition camera attached to a zoom lens,with a green illumination LED-engine.Calibration is provided using a calibrated quartz capillary tube and human blood at a known flow rate.Optical properties of liquid phantoms are retrieved from measured reflectance using the LUT,and blood flow measurements in the retina are presented.

关键词： Retinal oximetry fundus ophthalmoscope multi-aperture camera blood flow velocity diabetic retinopathy

Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

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Eye and Vision 2018年第1期5卷 260-268页

作者： Liang Wang Ohemaa Kwakyi James Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Neurology Population Health and OphthalmologyNew York University School of MedicineNew YorkNYUSA Departments of Neurology and Ophthalmology University of Texas Austin Dell Medical SchoolAustinTXUSA

Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal BFV.The primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC eyes.Methods:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 HCs.One eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with RFI.Results:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in HCs.Very strong inter-eye correlations were also found between arteriolar(r=0.84,Pblood flow alterations in MS.Future larger studies are needed to assess differenc

关键词： Inter-eye correlation blood flow velocity Retinal function imager Neurology Multiple sclerosis Optic neuropathy

Prognostic value of Doppler transmitral filling patterns in patients with chronic heart failure

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Chinese Medical Journal 2004年第2期17卷 176-182页

作者：郑哲岚 A.Meissner B.Hausmann H.Alexander R.Simon Department of Ultrasonography First Affiliated Hospital Zhejiang University College of Medicine Hangzhou 310003 China Department of Cardiology Kiel University Hospital Germany

Background Chronic heart failure is a significant cause of cardiovascular morbidity and mortality. This study tested the hypothesis that restrictive filling pattern may provide useful prognostic data for identifying patients with chronic heart failure at high risk of all-cause cardiac death.Methods Ninety patients with chronic heart failure [ 70 men and 20 women, mean age (58.1 ± 11.6) years] were investigated and followed for (18. 8 ±7. 9) months. During this period, 14 patients died of progressive pump failure, 12 patients underwent heart transplantation, 5 patients died suddenly, and 2 patients died of acute myocardial infarction. A new criterion, the restrictive filling index (RFI), was designed to subgroup patients into a restrictive and a nonrestrictive group.Results Patients with restrictive filling pattern had a more severe left ventricular dysfunction and a higher cardiac mortality. Analysis by the Kaplan-Meier method revealed that patients in the RFI≥1 and RFI <1 groups had a cardiac events-free survival rate of 52% versus 94% at 1 year, and 27. 5% versus 92% at 2 years, respectively. The multivariate Cox proportional hazard model selected RFI as the most powerful prognostic factor (x2 =8. 8017, P=0. 0030) for all-cause cardiac death.Conclusion These results indicate that RFI is a simple, noninvasive, and specific clinical predictor for adult chronic heart failure patients who are at a high risk for all-cause cardiac death.

关键词： prognosis echocardiography Doppler heart failure congestive blood flow velocity

Left atrial appendage flow velocity in rheumatic mitral stenosis

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Chinese Medical Journal 2004年第2期17卷 299-300页

作者：黄鹤唐红刘淑华饶莉曾焕琼 Department of Cardiology West China Hospital Sichuan University Chengdu 610041 China

The left atrial appendage ( LAA ) has been considered a relatively insignificant portion of the cardiac anatomy. Because thrombi have been found to have a predilection to form within the LAA, a better understanding of... 详细信息

关键词： Adolescent Adult Atrial Appendage blood flow velocity Echocardiography, Transesophageal Female Humans Male Middle Aged Mitral Valve Stenosis Rheumatic Heart Disease Thromboembolism

The retinal function imager and clinical applications

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Eye and Vision 2018年第1期5卷 191-195页

作者： Daniel Su Sunir Garg The Retina Service of Wills Eye Hospital Mid Atlantic Retina840 Walnut StreetSuite 1020PhiladelphiaPA 19107USA

Background:The Retinal Function Imager(RFI)provides in vivo and noninvasive imaging of both the retinal structure and function.Review:The RFI can create capillary perfusion maps,measure blood flow velocity,and determine metabolic function including blood oximetry.It can aid clinical diagnosis as well as assess treatment response in several retinal vascular diseases including diabetic retinopathy.blood flow velocity abnormalities have also been implicated in disease such as age-related macular degeneration and require further investigation.Compared with optical coherence tomography angiography,the RFI produces capillary maps of comparable image quality and wider field of view but it is unable to provide depth-resolved information and has longer image acquisition time.Currently,functional imaging using blood oximetry has limited applications and additional research is required.Conclusion:The RFI offers noninvasive,high-resolution imaging of retinal microvasculature by creating capillary perfusion maps.In addition,it is capable of measuring retinal blood velocity directly and performs functional imaging with retinal blood oximetry.Its clinical applications are broad and additional research with functional imaging may potentially lead to diagnosis of diseases and their progression before anatomic abnormalities become evident,but longer image acquisition times may limit its clinical adoption.

关键词： Retinal function imager Retinal blood flow blood flow velocity Oximetry Noninvasive imaging Retina

Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronary artery disease by using intracoronary myocardial contrast echocardiography and two other angiographic techniques

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Frontiers of Medicine 2007年第1期1卷 62-67页

作者： WANG Hong HUANG Lan JIN Jun SONG Yaoming GENG Zhaohua YU Xuejun QIN Jun ZHAO Gang GAO Yunhua LIU Zheng YANG Li Department of Cardiology Xingqiao HosipitalThird Military Medical UniversityChongqing 400037China Department of Ultrasoundy Xingqiao HosipitalThird Military Medical UniversityChongqing 400037China

Detection of abnormal myocardial perfusion is crucial to the prognosis of patients with coronary artery disease(CAD)after they have undergone percutaneous coronary intervention(PCI).The objective of this study is to evaluate the effect of myocardial perfusion by three different methods—intra-coronary myocardial contrast echocardiography(ICMCE),corrected thrombolysis in myocardial infarction frame count(CTFC),and coronary blood flow velocity(BFV)—and to determine the value of these different methods in the evaluation of the effect of myocardial perfusion post-PCI.For the study sixty-eight patients were divided into four groups based on selective coronary angiography results:group A(normal coronary artery),group B(75%–95%coronary artery stenosis),group C(coronary artery stenosis>95%)and group D(acute total coronary occlusion).The effect of myocardial reperfusion was evaluated using the above mentioned three methods 15 min after PCI.IC-MCE was also performed before PCI in group D.The quantitative parameters of MCE involved:contrast peak intensity,time to peak intensity and area under the curve,representing myocardial blood volume,reperfusion velocity and myocardial blood flow,respectively.No difference was found in CTFC between the coronary artery stenosis group and the normal group.BFV was slower in group D than in group A(Pblood volume and the myocardial blood flow of the IC-MCE quantitative parameters were markedly lower in group C compared with those in group A(P<0.05),and there were significant differences in the three MCE parameters between group D and group A(P<0.05).For those patients with acute or total occlusion,the levels of myocardial perfusion before and after PCI were similar,as determined by IC-MCE and visually analyzed from 61 segments(P<0.05).Quantitative IC-MCE evaluation of myocardial reperfusion is more accurate than with the other two methods.Moreover,with qualitative IC-MCE the level of myocardial reperfusion can be viewed directly and rapidly.Thus,the IC-MCE method is of

关键词： percutaneous coronary intervention coronary artery disease intra-coronary myocardial echocardiography corrected thrombolysis in myocardial infarction frame count blood flow velocity

Cynodon dactylon andSida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos

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The Journal of Biomedical Research 2012年第2期26卷 90-97页

作者： Rajaretinam Rajesh Kannan Samuel Gnana Prakash Vincent International Center for Nanobiotechnology (ICN) Center for Marine Science and Technology (CMST)Manonmaniam Sundaranar UniversityRajakkamangalamKanyakumari DistTamil Nadu 629502India

The aim of the present study was to screen cardioactive herbs from Western Ghats of India. The heart beat rate （HBR） and blood flow during systole and diastole were tested in zebrafish embryos. We found that Cynodon dactylon （C. dactylon） induced increases in the HBR in zebrafish embryos with a HBR of （3.968±0.344） beats/ s, which was significantly higher than that caused by betamethosone [（3.770±0.344） beats/s]. The EC50 value of C. dactylon was 3.738 μg/mL. The methanolic extract of Sida acuta （S. acuta） led to decreases in the HBR in zebrafish embryos [（1.877 ±0.079） beats/s], which was greater than that caused by nebivolol （positive control）. The EC50 value of Sida acuta was 1.195 μg/mL. The untreated embryos had a HBR of （2.685±0.160） beats/s at 3 d post fertilization （dpf）. The velocities of blood flow during the cardiac cycle were （2,291.667 ±72.169） μm/s for the control, （4,250± 125.000） μm/s for C. dactylon and （1,083.333±72.169） μm/s for S. acuta. The LC50 values were 32.6 μg/mL for C. dactylon and 20.9 μg/mL for S. acuta. In addition, the extracts exhibited no chemical genetic effects in the drug dosage range tested. In conclusion, we developed an assay that can measure changes in cardiac function in response to herbal small molecules and determine the cardiogenic effects by microvideography.

关键词： cardiogenesis small molecules heart beat rate assay blood flow velocity zebrafish embryo

Effect of swimming training on neural microcirculation in rats with sciatic nerve compression A study based on laser Doppler flowmetry

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Neural Regeneration Research 2010年第19期5卷 1510-1514页

作者： Yueming Gao Xinglin Wang Senyang Lang Lining Zhang Wei Suo Tianyu Jiang Jingping Fan Department of Physical Therapy General Hospital of Chinese PLA Beijing 100853 China

Microcirculation of the peripheral nerve is necessary for neural growth and regeneration. However, technical limitations have limited studies in this area. The few studies conducted have concerned active exercise effects on microcirculation of the peripheral nerve. Using an animal experiment, this study evaluated the effect of swimming training on microcirculation of injured peripheral nerve by laser Doppler flowmetry. The results showed that the blood vessel at the distal end of the peripheral nerve was the main blood supply for the nerve, and the internal blood supply for the nerve had strong compensatory ability. Swimming training promoted the functional recovery of rats with sciatic nerve injury and the regeneration of myelin sheath and blood vessels, but had no impact on neural blood flow.

关键词： sciatic neuropathy angiogenesis swimming autogenic training blood flow velocity laser Doppler flowrnetry

Recent advancement in diagnosis of vasculogenic impotence

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Asian Journal of Andrology 1999年第1期1卷 37-43页

作者： Sae Chul Kim Department of Urology College of Medicine Chung-Ang University Seoul Korea

Several dynamic tests with vasoactive drags are available for evaluating penile vascular inflows and outflows,ranging from simple pharmacologic test to more invasive radiologic sets. However, there is still no perfect single testto reflect the penile vascular flow. All possible efforts should be exerted to get the greatest erectile effect to avoid anunderestimation of blood flow to the corpora due to incomplete relaxation of the trabecular smooth muscle.Appreciation of the type and frequency of anatomical variations and potential collateral routes is important in interpretingpenile arterograms and in evaluating the hemodynamic significance of suspected arterial disease. Choice of the vasculartests should always depend on the purpose of testing.

关键词： vasculogenic impotence diagnosis cavernosography cavernosometry penile erection blood flow velocity hemodynamics angiography