检索结果-南通市图书馆

Atomic-iodine-substituted polydiacetylene nanospheres with boosted intersystem crossing and nonradiative transition through complete radiative transition blockade for ultraeffective phototherapy

Aggregate

引用

Aggregate 2024年第5期5卷 287-296页

作者： Dan Zhao Lingling Zhang Mingming Yin Zhenyan He Fang Fang Minle Zhan Sidan Tian Fanling Meng Liang Luo National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanChina

The energy dissipation pathways of a photosensitizer for phototherapies,including photodynamic therapy(PDT)and photothermal therapy(PTT),compete directly with that of itsﬂuorescence(FL)*** heavy atoms on theπ-conjugated systems and aggregation-caused quenching are two effective methods to turn off the FL emission of photosensitizers,which is expected to boost the inter-system crossing(for PDT)and nonradiative transition(for PTT)of photosensitizers for maximized phototherapeutic efﬁ*** this approach,an all-iodine-substituted polydiacetylene aggregate poly(diiododiacetylene)(PIDA)has been developed,which shows a superior near infrared absorption(ε_(808nm)=26.1 g^(-1) cm^(-1) L)with completely blocked FL,as well as high efﬁciency of reactive oxygen species generation(nearly 45 folds of indocyanine green)and photothermal conversion(33.4%).To make the insolubleﬁbrillar PIDA aggregates favorable for systemic administration,they are converted into nanospheres through a pre-polymerization morphology transformation *** in vivo study on a 4T1 tumor-bearing mouse model demonstrates that PIDA nanospheres can almost eliminate the tumor entirely in 16 days and prolong the survival time of mice to over 60 days,validating their effective phototherapeutic response through the strategy of inhibiting FL for boosted intersystem crossing and nonradiative transition.

关键词： blockedﬂuorescence emission heavy atom effect morphology transformation phototherapy polydi-acetylene aggregate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：