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Short-term outcomes of mitomycin C-augmented excisional bleb revision with capsulectomy for failed Ahmed glaucoma valve

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 947-953页

作者： Bar Davidov Shimon Kurtz Ilona Mohilevtseva Michael Waisbourd Rony Rachmiel Glaucoma Center Department of OphthalmologyTel Aviv Sourasky Medical CenterAffiliated to the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 64239Israel

AIM: To report short-term outcomes of mitomycin C-augmented excisional bleb revision with capsulectomy(ERC) after Ahmed glaucoma valve(AGV) ***: Patients who underwent ERC procedures between January 2017 and December 2019 with a minimum follow-up of 6mo were evaluated retrospectively for indications of AGV and AGV implantation to ERC *** number of anti-glaucoma medications(AGMs),intraocular pressure(IOP) and best corrected visual acuity(BCVA) were recorded at baseline, 1, 7, 30, 90, and ***-and postoperative complications were also *** outcome was defined as IOP≤21 mm Hg with or without ***: Fourteen eyes [14 patients, median age 69.5y, interquartile range(IQR) 61.3-80] were *** glaucoma(n=5, 36%) was the most common form of glaucoma. The median AGV implantation to ERC interval was 8.8mo(IQR 3.91-43.67). At 6mo, the median number of AGMs decreased from 3.0(IQR 3.0-4.0)to 2.0(IQR 1.5-3), the median IOP decreased from 26 mm Hg(IQR 22-29) to 16.5 mm Hg(IQR 13.75-20) and there was no significant change in BCVA. The success rate at 6mo was 92.9%. The Kaplan-Meier cumulative probability of survival was 93%, 79%, 64%, and 64% at 1wk, and 1,3, and 6mo, respectively. No intraoperative complications were identified. Postoperative complications were identified in 5 eyes(36%), which were resolved spontaneously during the first week following ***: ERC has a high success rate for shortterm management of AGV failure. A longer follow-up study is required to determine long-term cumulative failure rates.

关键词： glaucoma Ahmed bleb capsulectomy mitomycin C

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Pulmonary embolism during pregnancy in a case of blue rubber bleb nevus syndrome

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Chinese Medical Journal 2019年第12期132卷 1499-1501页

作者： Yan-Li Liu Yan-Ping Jiang Juan Du Department of Obstetrics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China

To the Editor:Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular disorder characterized by multiple venous malformations involving many *** can occur in various organs,but the most frequently involved organs are the skin and gastrointestinal *** lesions of BRBNS can cause acute or chronic bleeding and anemia.[1] Only several case reports of pregnant women with BRBNS could be found in the current database and most of them were complicated by hemorrhage of the gastrointestinal *** report a case of BRBNS during pregnancy that suffered from severe pulmonary embolism (PE) and was successfully resuscitated.

关键词： Pulmonary embolism pregnancy blue rubber bleb nevus syndrome

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Endoscopic therapy for esophageal hematoma with blue rubber bleb nevus syndrome

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World Journal of Gastrointestinal Endoscopy 2014年第12期6卷 630-634页

作者： Mika Takasumi Takuto Hikichi Tadayuki Takagi Masaki Sato Rei Suzuki Ko Watanabe Jun Nakamura Mitsuru Sugimoto Yuichi Waragai Hitomi Kikuchi Naoki Konno Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine Department of Endoscopy Fukushima Medical University Hospital

A 57-year-old woman previously diagnosed with blue rubber bleb nevus syndrome(BRBNS) reported hematemesis. BRBNS is a rare vascular anomaly syndrome consisting of multifocal hemangiomas of the skin and gastrointestinal(GI) tract but her GI tract had never been examined. An upper gastrointestinal endoscopy revealed a large bleeding esophageal hematoma positioned between the thoracic esophagus and the gastric cardia. An endoscopic injection of polidocanol was used to stop the hematoma from bleeding. The hematoma was incised using the injectionneedle to reduce the pressure within it. Finally, argon plasma coagulation(APC) was applied to the edge of the incision. The esophageal hematoma disappeared seven days later. Two months after the endoscopic the rapy, the eso phage alulcerhealed and the hemangioma did not relapse. This rare case of a large esophageal hematoma originating from a hemangioma with BRBNS was treated using a combination of endoscopic therapy with polidocanol injection, incision, and APC.

关键词： Blue rubber bleb nevus syndrome Endoscopic injection sclerotherapy Incision Esophageal hematoma Esophageal hemangioma

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Modified Cortex Mori Capsules improving the successful rate of functional filtering blebs after reclinical glaucoma filtering surgery

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World Journal of Clinical Cases 2019年第21期7卷 3436-3445页

作者： Jing Yu Li-Xin Qiu Guo-Ping Qing Bo-Wen Zhao Hui Wang Beijing Tongren Eye Center Laboratory of Ophthalmology and Visual Science in Beijing Beijing Tongren HospitalCapital Medical University

BACKGROUND The major reason for filtering bleb failure or scarring of the bleb site is due to excessive scarring after glaucoma filtration surgery in the *** Chinese medicine has preeminence in the prevention of fibrosis formation through the regulation of systemic circulation and improvement of the properties of the inflammatory cells in the *** To examine the clinical efficacy of using the Modified Cortex Mori Capsules(MCMC;Chinese name:Jiawei Sangbaipi Capsules)in the success rate of functional filtering blebs after glaucoma filtering surgery in clinical *** Sixty resurgery glaucoma patients were randomly divided into two groups:30 patients in surgery with the placebo group and 30 patients in surgery with the MCMC *** took either the placebo or the MCMC 2 wk before and after *** morphology and function filtering bleb,visual acuity,intraocular pressure,postoperative complications,the success rate of filtration surgery and clinical efficacy were *** Fifty patients completed the *** percentage of functional filtering blebs in the surgery plus MCMC group was 84%at 6 mo after surgery,which was higher than surgery plus placebo group(64%,Pblebs but also improved the success of glaucoma filtration operations.

关键词： Glaucoma Traditional Chinese medicine Modified Cortex Mori Capsules Jiawei Sangbaipi Capsules Filtering bleb Scar formation

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Postoperative adjunctive bevacizumab versus placebo in primary trabeculectomy surgery for glaucoma

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1567-1574页

作者： Sana’Muhsen Javiera Compan Tze Lai Christoph Kranemann Catherine Birt Department of Ophthalmology School of MedicineTheUniversity of JordanAmman11942Jordan Department of Ophthalmology and Vision Sciences University of TorontoToronto ON M4N3M5Canada Department of Ophthalmology Curtin UniversityWesternAustraliaGPO Box U1987Perth WA6845Australia

AIM: To compare the effectiveness of postoperative adjunctive use of subconjunctival bevacizumab in altering the outcome of primary trabeculectomy in terms of sustained lowering of intraocular pressure(IOP) and reduction of postoperative bleb vascularization and ***: A prospective, one center, randomized, placebo-control study. Fifty-nine patients(59 eyes) with uncontrolled IOP under maximal tolerated medical treatment(MTMT) were recruited. A primary trabeculectomy with mitomycin C(MMC) was done and the patients were randomized to either postoperative subconjunctival injection of bevacizumab(1.25 mg/0.05 mL) or balanced salt solution(BSS). Forty-seven patients(47 eyes) completed at least one year of follow up and were included in the study. The main outcome measure was the IOP, and secondary outcome measures include bleb morphology, vascularization, and fibrosis, as well as the need for glaucoma medications and 5-fluorouracil(5-FU) ***: At 1-year follow up, there was no significant difference between groups for IOP(P=0.65), bleb morphology(P=0.65), and the need for glaucoma medications(P=0.65) or 5-FU needling requirements(P=0.11). However, the bevacizumab group had a higher rate of success results, lower use of glaucoma medications after surgery, and optimal bleb aspect in more patients, but more 5-FU needling procedures required. CONCLUSION: A bigger sample size is needed in order to determine whether the differences found in the bevacizumab group are statistically significant.

关键词： glaucoma trabeculectomy bevacizumab bleb

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