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Immuno-Protective Efficiency of the bivalent inactivated vaccine Against Vibrio scophthalmi and Aeromonas salmonicida Infections in Turbot(Scophthalmus maximus L.)

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Journal of Ocean University of China 2023年第4期22卷 1079-1086页

作者： ZHOU Shun ZHENG Xujia DING Yuanyuan SU Lin HUANG Qing XIU Yunji School of Marine Science and Engineering Qingdao Agricultural UniversityQingdao 266109China

Vibrio scophthalmi and Aeromonas salmonicida can cause high turbot mortality and huge economic ***,vaccination is the most promising method for preventing communicable *** this study,we used formalin to kill *** and *** cells,and mixed with the mineralized oil adjuvant(Montanide^(TM)ISA 763 AVG)to prepare the bivalent inactivated *** results showed that turbot inoculated with the bivalent inactivated vaccine exhibited strong tolerance to the infection of *** and ***,and no obvious clinical symptoms and pathological changes were *** activities of enzymes lysozyme,acid phosphatase and complement C3 had significantly increased after the *** antibody titer response of vaccinated turbot was greatly boosted,which was positively connected with the immunological impact according to ELISA ***,the expression levels of immune-related genes such as MHC-IIα,MHC-IIβ,CD4,CD8,TNF-αand IL^(-1)βwere up-regulated,demonstrating that it might stimulate humoral and cellular immunological response in *** findings highlight the potential of the bivalent inactivated vaccine for controlling *** and *** infections in turbot.

关键词： Aeromonas salmonicida Vibrio scophthalmi bivalent inactivated vaccine immune response

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Mucosal immune responses and protective efficacy in yellow catfish after immersion vaccination with bivalent inactivated Aeromonas veronii and Edwardsiella ictaluri vaccine

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Water Biology and Security 2022年第2期1卷 38-48页

作者： Wei Guang Kong Da Cheng Qin Qing Jiang Mu Zhao Ran Dong Yang Zhi Luo Tao Shan Ai Zhen Xu State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei430072China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhanHubei430070China Wuhan Chopper Fishery Bio-Tech Co. LtdWuhan Academy of Agricultural ScienceWuhan430207China

Mucosal vaccination,which has the potential to induce both mucosal and systemic immune responses,is considered the most suitable method of preventing infectious diseases in farmed *** veronii and Edwardsiella ictaluri are two pathogenic bacteria found in yellow catfish and often infect the fish through mucosal *** of a bivalent inactivated vaccine by injection has been shown to induce a strong systemic immune response against both bacterial ***,mucosal immune responses and protective efficiency induced by this inactivated vaccine administrated via immersion are yet to be *** developed a bivalent vaccine containing formalin-inactivated *** and *** and evaluated the immune response in yellow catfish after immersion vaccination using body fluids biochemistry indices,agglutinating antibody titers,and the expression level of immune-related genes in the skin,gills,spleen,and head *** activities of innate immune-related enzymes and specific agglutination antibody titers in body fluids,as well as the expression of innate and adaptive immune-related genes in both the mucosal and systemic tissues of vaccinated fish,were significantly higher than that in control ***,we assessed the protective efficacy by a challenge model of virulent strains of *** and *** relative survival percent of vaccinated fish was 80%and 87%after challenging fish with *** and ***,respectively,which was higher than unvaccinated control fish(43%and 57%).These results confirm that the bivalent inactivated vaccine administered via immersion induces a strong mucosal immune response and confers good protection against both *** and *** results also reinforce the notion that immersion vaccination could stimulate both mucosal and systemic immunity contributing to protection against pathogens.

关键词： Mucosal immune response bivalent inactivated vaccine Immersion vaccination Aeromonas veronii Edwardsiella ictaluri Yellow catfish

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