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Ultrasound-induced biophysical effects in controlled drug delivery

Science China(Life Sciences) 2022年第5期65卷 896-908页

作者： Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge Department of Ultrasound Peking University Third HospitalBeijing 100191China

Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug *** advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery *** review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound ***,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are ***,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in ***,recent advances in ultrasound-triggered drug delivery are *** issues and optimization strategies to improve therapeutic outcomes and reduce side effects are ***,current progress and future directions are discussed.

关键词： ultrasound biophysical effects drug delivery systems ultrasound parameters ultrasound-triggered drug delivery

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The climatic impacts of land use and land cover change compared among countries

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Journal of Geographical Sciences 2016年第7期26卷 889-903页

作者：刘纪远邵全琴延晓冬樊江文战金艳邓祥征匡文慧黄麟 Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research CAS Beijing Normal University

Land use and land cover change(LULCC) strongly influence regional and global climate by combining both biochemical and biophysical processes. However, the biophysical process was often ignored, which may offset the biogeochemical effects, so measures to address climate change could not reach the target. Thus, the biophysical influence of LULCC is critical for understanding observed climate changes in the past and potential scenarios in the future. Therefore, it is necessary to identify the mechanisms and effects of large-scale LULCC on climate change through changing the underlying surface, and thus the energy balance. The key scientific issues on understanding the impacts of human activities on global climate that must be addressed including:(1) what are the basic scientific facts of spatial and temporal variations of LULCC in China and comparative countries?(2) How to understand the coupling driving mechanisms of human activities and climate change on the LULCC and then to forecasting the future scenarios?(3) What are the scientific mechanisms of LULCC impacts on biophysical processes of land surface, and then the climate?(4) How to estimate the contributions of LULCC to climate change by affecting biophysical processes of land surface? By international comparison, the impacts of LULCC on climate change at the local, regional and global scales were revealed and evaluated. It can provide theoretical basis for the global change, and have great significance to mitigate and adapt to global climate changes.

关键词： land use and land cover change climate change biophysical effects model simulation

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