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检索条件"主题词=bioorthogonal cleavage reaction"

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Manipulating the function of biomolecules via the bioorthogonal cleavage reaction

Manipulating the function of biomolecules via the bioorthogo...

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第十届全国化学生物学学术会议

作者： Jie Wang Peng Chen Department of Chemical Biology College of Chemistry and Molecular EngineeringPeking University

bioorthogonal cleavage reaction has emerged as an attractive strategy for release the function of biomolecules, which enable us to study intracellular biomolecules in a gain-of-function way. When a caged precursor was incorporated into the key site of a biomacromolecule, the function of the biomolecule was blocked. Subsequently, the function will be recused when the caging group was removed by small molecule reagents. We reported various bioorthogonal chemical decaging reactions, including palladium triggered and Inverse electronic demand D-A reaction triggered decaging reactions. These reactions were applied for manipulating the function of cell surface glycans and intracellular proteins.

关键词： bioorthogonal cleavage reaction unnatural amino acid sialic acid chemical decaging

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The application of Cu-mediated bioothogonal cleavage reaction in living system

The application of Cu-mediated bioothogonal cleavage reactio...

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第十届全国化学生物学学术会议

作者： Xin Wang Yanjun Liu Peng R.Chen Beijing National Laboratory for Molecular Sciences Synthetic and Functional Biomolecules CenterDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking University

bioorthogonal reaction pairs are playing more and more important role in chemical biology. Compared to traditional bioorthogonal coupling reaction, the biorthogonal cleavage reaction is brought into focus in recent years. So in this work, we developed a copper-mediated bioorthogonal cleavage pair. Then we expended this pair on activation of prodrug, unnatural amino acid for protein activation in living cells. At last, we proposed that it could be as a linker of antibody-drug conjugate for cancer therapy in living animals.

关键词： copper bioorthogonal cleavage reaction unnatural amino acid

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利用“脱笼”反应发展蛋白质激活新方法（英文）

利用“脱笼”反应发展蛋白质激活新方法（英文）

引用

第十届全国化学生物学学术会议

作者： Jie Wang Peng Chen Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University

bioorthogonal cleavage reaction has emerged as an attractive strategy for release the function of biomolecules, which enable us to study intracellular biomolecules in a gain-of-function way. When a caged precursor was incorporated into the key site of a biomacromolecule, the function of the biomolecule was blocked. Subsequently, the function will be recused when the caging group was removed by small molecule *** reported various bioorthogonal chemical decaging reactions, including palladium triggered and Inverse electronic demand D-A reaction triggered decaging reactions. These reactions were applied for manipulating the function of cell surface glycans and intracellular proteins.

关键词： bioorthogonal cleavage reaction unnatural amino acid sialic acid chemical decaging

来源： cnki会议评论

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