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Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair

International Journal of Extreme Manufacturing 2023年第3期5卷 264-300页

作者： Juqing Song Baiheng Lv Wencong Chen Peng Ding Yong He School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808People’s Republic of China China Nuclear Power Technology Research Institute Co. LtdShenzhen 518000People’sRepublicof China School of Mechanical Engineering Zhejiang UniversityHangzhou310058People’s Republic of China

Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not *** an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed ***,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and *** this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in *** that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing ***,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.

关键词： peripheral nerve regeneration spinal cord repair 3D printing construct bionic structure bionic function

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