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Recent Development of DNA-modified AIEgen Probes for biomedical application

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Chemical Research in Chinese Universities 2021年第1期37卷 66-72页

作者： HU Qinyu WU Jun CHEN Lulu LOU Xiaoding XIA Fan Engineering Research Center of Nano-Geomaterials of the Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430074P.R.China

A variety of DNA-based probes are utilized for the detections of multiple analytes and DNA nanotechnology has been thriving for recent decades and achieving numerous nanostructures,mainly focusing on DNA morphology modulation and multifunctional systems engineered into to the complicated *** the numerous detections,fluorescence method is a non-invasive,highly selective and sensitive means for varieties of applications,but their emissions are often compromised by the aggregation-caused quenching(ACQ)effect,which weakens their *** aggregation induced emission luminogens(AIEgens)are created with non emissive or weakly emissive in a low concentration but emit strong fluorescence in a high concentration with aggregated ***,numerous functionalized AIEgens have been emerged and used for detection and imaging and DNA-modified AIEgen probes are *** this vein,here we report the progress on DNA-modified AIEgen probes in recent years and highlight their conjugation strategies including covalent bonding,electrostatic interaction and their applications of ***,multiple DNA strands are needed to introduce into the DNA-modified AIEgen probes for more *** the end,some challenges are mentioned to discuss the new trend of DNA-modified AIEgen probes.

关键词： Aggregation induced emission luminogen(AIEgen) DNA-modified probe Detection Imaging biomedical application

Functional Xeno Nucleic Acids for biomedical application

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Chemical Research in Chinese Universities 2022年第4期38卷 912-918页

作者： TU Tingting HUAN Shuangyan KE Guoliang ZHANG Xiaobing State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

Functional nucleic acids(FNAs)refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids,which have been widely applied in screening,sensing and imaging ***,the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability,biocompatibility,biodistribution and immunity of natural nucleic acids(DNA/RNA).Xeno nucleic acids(XNAs)are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties,including improved biological stability,increased binding affinity,reduced immune responses,and enhanced cell penetration or tissue *** the last two decades,scientists have made great progress in the research of functional xeno nucleic acids,which makes it an emerging attractive biomedical application *** this review,we summarized the design of functional xeno nucleic acids and their applications in the biomedical field.

关键词： Functional nucleic acid Xeno nucleic acid Chemical modification biomedical application

Providing insight into exchange coupling within nanomagnetism:mechanism,micromagnetic simulation,synthesis and biomedical application

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Science China Materials 2024年第10期67卷 3049-3082页

作者： Yuting Tang Feng Feng Guanhua Xu Shijie Qin Xiaoping Ouyang Li Yao Xiuyu Wang Institute of Process Equipment College of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesCAS Research/Education Center for Excellence in Molecular SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Exchange coupling within nanomagnetism is a rapidly evolving field with significant implications for that plays a crucial role in the development of magnetic *** exchange coupling interaction enables the magnetic systems to overcome limitations associated with size-dependent magnetic behavior within nano scale,thereby improving their magnetic properties and providing for superior performance in biomedical applications compared with single-phase magnetic *** the underlying mechanism of exchange coupling and its impact on macroscopic magnetic properties is crucial for the design and application of such magnetic *** review provides an overview of recent advances in interfacial exchange coupling among different magnetic modalities-ferromagnetism,ferrimagnetism,and antiferromagnetism-based on core-shell magnetic nanoparticles(MNPs).Additionally,this review discusses micromagnetic simulations to gain insights into the relationship between the microscopic magnetic structure(size,shape,composition,and exchange coupling)and the resulting macroscopic *** controlled synthesis of MNPs is summarized,including one-step method and two-step *** precise manipulation of interfacial characteristics is of great importance,albeit challenging,as it allows for the finetuning of magnetic properties tailored for specific *** review also explores potential applications of coreshell MNPs in magnetic resonance imaging,hyperthermia therapy,targeted drug delivery,and advanced neuromodulation.

关键词： nano magnetism heterogeneous interfaces exchange coupling micromagnetic simulation biomedical application

FUNCTIONAL IMMUNITY TEST FOR FIELD PROGRAMMABLE ANALOG ARRAYS（FPAA）-BASED biomedical application TO EM RADIATED ENERGY

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FUNCTIONAL IMMUNITY TEST FOR FIELD PROGRAMMABLE ANALOG ARRAY...

biomedical applications of gelatin methacryloyl hydrogels

The Sixth Asia-Pacific Conference on Environmental Electromagnetics(CEEM’2012)

作者： Dalila.Salhi Nicola Pasquino Dept.Of Electrical Engineering University of Naples Federico Ⅱ Via Claudio 21-80125 NapoliItaly

＜正＞Nowadays,the field programmable analog arrays or FPAAs provides a very promising analog solutions to substitute the most costly analog applications to be implemented into complex systems in the goal of reducing their cost and their prototyping time,in biomedical applications this fact should be very interesting specially for supporting life and portable devices, nevertheless,their parametric characterization to be suitable for this applications is not enough when we take in account the influence of external disturbances on the possible distorted behaviour of such devices,in this paper,we present the results of a functional immunity test of an FPAA-based biomedical application involving ECG signal conditioning to EM radiated energy over a electromagnetic field over frequency range from 80 MHz to 3 GHz..

关键词： Radiated Immunity test Field programmable Analog Arrays FPAA ECG Functional test signal conditioning biomedical application Electromagnetic Compatibility measurements

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Engineered Regeneration 2021年第1期2卷 47-56页

作者： Yun Piao Hengze You Tianpeng Xu Ho-Pan Bei Imanuel Zvi Piwko Yu Yan Kwan Xin Zhao Department of biomedical Engineering the Hong Kong Polytechnic UniversityHung HomHong KongChina

Gelatin methacryloyl(GelMA)has attracted the widespread interest of researchers because of its excellent biocompatibility,biodegradability,and *** structures have been constructed from GelMA hydrogel,including 3D scaffold,injectable gel,bio-printed scaffold,and electrospun fibrous membrane via precise fabrication methods such as light-induced crosslinking,extrusion 3D printing,electrospinning,or *** to its unique characteristics and simple preparation,GelMA hydrogel demonstrates superior performance and promising potential in a broad range of biomedical applications involving wound healing,drug delivery,biosensing,and tissue *** review integrates sufficient research works on GelMA hydrogels in the regeneration of tissues such as skin,tendon,bone,cartilage,blood vessel,and cardiovascular system,in addition to applications in drug delivery,organ-on-a-chip,and biosensing,providing a critical review of present work and offering future implications.

关键词： GelMA biomedical application Tissue engineering

Near-infrared aggregation-induced emission materials:Bibliometric analysis and their application in biomedicalﬁeld

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Aggregate

Aggregate 2024年第3期5卷 78-106页

作者： Qian He Meiyiming Wang Li Zhao Bin Xu Wenjing Tian Liyun Zhang Shanxi Bethune Hospital Shanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxiChina State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilinChina

Aggregation-induced emission(AIE)is an intriguing photophysical phenomenon,where speciﬁc materials exhibit a remarkable surge in luminescence when brought together in non-ideal solvents or within a solid *** the concept of AIE wasﬁrst introduced in 2001,numerous advanced applications have been gradually explored across various domains,including optics,electronics,energy,and the life *** particular note is the growing interest in the application of AIE systems with near-infrared(NIR)emissive feature in theﬁeld of biomedicine,encompass-ing detection,imaging,and therapeutic ***,bibliometric analysis serves as a valuable tool to provide researchers with a comprehensive understand-ing of research achievements and developmental trends in speciﬁcﬁelds,which is crucial for academic ***,we present a general bibliometric overview spanning two decades of NIR-AIE *** the assistance of core scien-tiﬁc databases and various bibliometric software tools,we conducted a systematic analysis of annual publications and citations,the most inﬂuential countries/regions,leading authors,journals,and institutions,as well as the hot topics related to NIR applications and forward-looking ***,the application of AIE with NIR properties in the biomedicalﬁeld is also systematically reviewed.

关键词： aggregation-induced emission bibliometric analysis biomedical application near-infrared

Cell-based drug delivery systems for biomedical applications

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Nano Research 2018年第10期11卷 5240-5257页

作者： Teng Li He Dong Can Zhang Ran Mo State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of AdvancedPharmaceuticals and 8iomaterials China Pharmaceutical University Nanjing 210009 China

Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems （nano-DDSs） is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.

关键词： natural particulates nanotechnology bioinspired drug delivery biomedical application

Magnetic iron oxide nanoparticles: Synthesis and surface coating techniques for biomedical applications

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Chinese Physics B 2014年第3期23卷 13-31页

作者：孙圣男魏超朱赞赞侯仰龙 Subbu S Venkatraman 徐梽川 School of Materials and Science Engineering Nanyang Technological University Department of Chemical Engineering Worcester Polytechnic Institute Department of Materials Science and Engineering College of Engineering Peking University

Iron oxide nanoparticles are the most popular magnetic nanoparticles used in biomedical applications due to their low cost, low toxicity, and unique magnetic property. Magnetic iron oxide nanoparticles, including magnetite （Fe304） and maghemite （γ-Fe203）, usually exhibit a superparamagnetic property as their size goes smaller than 20 nm, which are often denoted as superparamagnetic iron oxide nanoparticles （SPIONs） and utilized for drug delivery, diagnosis, therapy, and etc. This review article gives a brief introduction on magnetic iron oxide nanoparticles in terms of their fundamentals of magnetism, magnetic resonance imaging （MRI）, and drug delivery, as well as the synthesis approaches, surface coating, and application examples from recent key literatures. Because the quality and surface chemistry play important roles in biomedical applications, our review focuses on the synthesis approaches and surface modifications of iron oxide nanopar- ticles. We aim to provide a detailed introduction to readers who are new to this field, helping them to choose suitable synthesis methods and to optimize the surface chemistry of iron oxide nanoparticles for their interests.

关键词： Fe3O4 γ-Fe203 synthesis surface coating biomedical application

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

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Bio-Design and Manufacturing 2022年第2期5卷 371-395页

作者： Masoud Sarraf Erfan Rezvani Ghomi Saeid Alipour Seeram Ramakrishna Nazatul Liana Sukiman Centre of Advanced Materials Department of Mechanical EngineeringFaculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Department of Materials Science and Engineering Sharif University of TechnologyAzadi Ave.P.O.Box 11365‑9466TehranIran Center for Nanotechnology and Sustainability Department of Mechanical EngineeringNational University of SingaporeSingapore 117581Singapore

Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950 *** to the excellent mechanical tribological properties,corrosion resistance,biocompatibility,and antibacterial properties of titanium,it is getting much attention as a biomaterial for ***,titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant *** properties are crucial for producing high-strength metallic alloys for biomedical *** alloys are manufactured into the three types ofα,β,andα+β.The scientific and clinical understanding of titanium and its potential applications,especially in the biomedical field,are still in the early *** review aims to establish a credible platform for the current and future roles of titanium in *** first explore the developmental history of ***,we review the recent advancement of the utility of titanium in diverse biomedical areas,its functional properties,mechanisms of biocompatibility,host tissue responses,and various relevant antimicrobial *** research will be directed toward advanced manufacturing technologies,such as powder-based additive manufacturing,electron beam melting and laser melting deposition,as well as analyzing the effects of alloying elements on the biocompatibility,corrosion resistance,and mechanical properties of ***,the role of titania nanotubes in regenerative medicine and nanomedicine applications,such as localized drug delivery system,immunomodulatory agents,antibacterial agents,and hemocompatibility,is investigated,and the paper concludes with the future outlook of titanium alloys as biomaterials.

关键词： Titanium and titanium alloys biomedical application Functional properties Biocompatibility Antibacterial activity Advanced manufacturing