检索结果-南通市图书馆

Natural alkaloids: basic aspects, biological roles, and future perspectives

Chinese Journal of Natural Medicines 2014年第6期12卷 401-406页

作者： QIU Shi SUN Hui ZHANG Ai-Hua XU Hong-Ying YAN Guang-Li HAN Ying WANG Xi-Jun National TCM Key Laboratory of Serum Pharmacochemistry Heilongjiang University of Chinese Medicine

Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation, antibacterial, antiviral, insecticidal, and antimetastatic effects on various types of cancers both in vitro and in vivo. This paper focuses on the naturally-derived alkaloids such as berberine, matrine, piperine, fritillarine, and rhynchophylline, etc., and summarizes the action mechanisms of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as drugs is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made. Following this, it is hoped that as a result of this review, there will be a greater awareness of the excellent promise that natural alkaloids show for use in the therapy of diseases.

关键词： Natural product Alkaloids biological roles Health benefits

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

VmNLP2 from Valsa mali acts as a phytotoxic virulence factor

VmNLP2 from Valsa mali acts as a phytotoxic virulence factor

引用

中国植物病理学会2021年学术年会

作者： LIU Jianying NIE Jiajun CHANG Yali HUANG Lili State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F University

Necrosis and ethylene-inducing peptide 1(Nepl)-like proteins(NLPs) are typically phytotoxic molecules and play important roles in plant-microbe ***,their biological roles in the pathogenic fungus Valsa mali,the causal agent of apple Valsa canker,remains ***,we identified two NLPs,VmNLPl and VmNLP2 from *** agrobacteriamediated transient expression in Nicotiana benthamiana,only VmNLP2 was shown to induce cell death and was subjected to further *** infiltration of VmNLP2 recombinant protein in apple leaves,we found that VmNLP2 exhibited phytotoxic activity in apple leaves as *** knockout and pathogenicity test showed that VmNLP2-deficient *** strain displayed reduced aggressiveness on *** sequence alignment revealed that the second Histidine(H) among the conserved heptapeptide(GHRHDWE) of VmNLP2 is mutated to Tyrosine(Y).When this Tyrosine(Y) was substituted by Histidine(H),the variant(VmNLP2) showed a stronger cell death 一 inducing activity in ***,complementation of VmNLP2 to VmNLP2 deletion mutant caused larger disease lesion on apple leaves,compared to the *** wild type *** together,we demonstrate that VmNLP2 from *** is an essential virulence factor,and the virulence of VmNLP2 probably correlates to its phytotoxic activity.

关键词： Valsa mali Nep1-like proteins cytotoxicity virulence factor biological roles

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：