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biological clock: the oscillator of gene expression

Science China(Life Sciences) 2018年第1期61卷 128-130页

作者： Qiang Yu Shanghai Institute of Materia Media Chinese Academy of Sciences

The 2017 Nobel prize in physiology or medicine was awarded to the discoveries of genes and molecular mechanisms of the circadian rhythm,which is any biological process that oscillates with a period of about 24 *** scientists from the United States,Jeffrey ***,Michael Rosbash,and Michael ***,shared the *** work is of great theoretical value in understanding the nature of life and the interactions of life with its environments.

关键词： biological clock

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A novel small-animal locomotor activity recording device for biological clock research

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Animal Models and Experimental Medicine 2024年第1期7卷 71-76页

作者： Yi-Long Wu Ming Zhong Jun Yin Wei-Jie Ou Yu-Bin Zhuang Nan-Wen Zhang Su Lin Yue-Yong Zhu Endoscopy Center The First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Endocrinology The First Affiliated HospitalFujian Medical UniversityFuzhouChina Chuangke Workshop Technology Co. LtdShenzhenChina Department of Digestive Nutrition Fujian Children's HospitalFuzhouChina Experimental Animal Center Fujian Medical UniversityFuzhouChina Department of Pharmacology Fujian Medical UniversityFuzhouChina Department of Hepatology Hepatology Research InstituteClinical Research Center for Liver and Intestinal Diseases of Fujian ProvinceThe First Affiliated HospitalFujian Medical UniversityFuzhouChina

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian *** study demonstrated how to construct a simple and intelligent running-wheel recording *** running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's ***,the RJ25 adaptor relayed the running signal to the main control ***,the main control board was connected to the USB port of the computer with the USB *** were collected using the online-accessible,self-created software *** Magturning,generated data were saved and exported in real ***,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light *** conclusion,this new device can record circadian activity of *** device is appropriate for interdisciplinary investigations related to biological clock research.

关键词： biological clock circadian rhythm intelligent equipment locomotor activity running wheel

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Modelling of intercellular synchronization in the Drosophila circadian clock

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Chinese Physics B 2009年第3期18卷 1294-1300页

作者：王军威陈爱敏张家军苑占江周天寿 School of Mathematics and Computational Science Sun Yat-Sen University

In circadian rhythm generation, intercellular signaling factors are shown to play a crucial role in both sustaining intrinsic cellular rhythmicity and acquiring collective behaviours across a population of circadian neurons. However, the physical mechanism behind their role remains to be fully understood. In this paper, we propose an indirectly coupled multicellular model for the synchronization of Drosophila circadian oscillators combining both intracellular and intercellular dynamics. By simulating different experimental conditions, we find that such an indirect coupling way can synchronize both heterogeneous self-sustained circadian neurons and heterogeneous mutational damped circadian neurons. Moreover, they can also be entrained to ambient light-dark （LD） cycles depending on intercellular signaling.

关键词： Drosophila biological clock circadian oscillation synchronization

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Circadian clock-Regulated Phosphate Transporter PHT4;1 Plays an Important Role in Arabidopsis Defense

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Molecular Plant 2011年第3期4卷 516-526页

作者： Guo-Ying Wang Jiang-Li Shi Gina Ng Stephanie L. Battle Chong Zhang Hua Lu Department of biological Sciences University of Maryland Baltimore County 1000 Hilltop CircLe Baltimore MD 21250 USA

The Arabidopsis accelerated cell death 6-1 （acd6-1） mutant shows constitutive defense, cell death, and ex- treme dwarf phenotypes. In a screen for acd6-1 suppressors, we identified a mutant that was disrupted by a T-DNA in the PHOSPHATE TRANSPORTER 4;1 （PHT4;1） gene. The suppressor mutant pht4;1-1 is dominant, expresses truncated PHT4;1 transcripts, and is more susceptible to virulent Pseudomonas syringae strains but not to several avirulent strains. Treat- ment with a salicylic acid （SA） agonist induced a similar level of resistance in Col-0 and pht4;1-1, suggesting that PHT4;1 acts upstream of the SA pathway. Genetic analysis further indicates that PHT4,1 contributes to SID2-dependent and -in- dependent pathways. Transgenic expression of the DNA fragment containing the PHT4;1-1 region or the full-length PHT4;1 gene in wild-type conferred enhanced susceptibility to Pseudomonas infection. Interestingly, expression of PHT4;1 is reg- ulated by the circadian clock. Together, these data suggest that the phosphate transporter PHT4;1 is critical for basal defense and also implicate a potential role of the circadian clock in regulating innate immunity of Arabidopsis.

关键词： biological clock disease resistance signal transduction Pseudomonas syringae phosphate transporter salicylic acid.

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Circadian rhythms in Arabidopsis and Brassica

Circadian rhythms in Arabidopsis and Brassica

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2011全国植物生物学研讨会

作者： C.Robertson McClung Department of biological Sciences Dartmouth CollegeHanoverNew Hampshire03755USA

The endogenous circadian clock confers an internal periodicity that synchronizes an organism with the environmental period imposed by Earth’s rotation;when internal and external periods diverge,performance measures such as net photosynthesis et al decline *** plants,both transcriptional and posttranslational mechanisms are prominent in the basic network architecture of circadian *** Arabidopsis thaliana,as in most other eukaryotes studied to date, the circadian clock includes multiple interlocked feedback *** we report two putative transcriptional factors,SA5,and its partially redundant homolog CS1,play

关键词： biological clock circadian rhythm transcriptional mechanism Arabidopsis thaliana Brassica rapa

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生物钟的调控

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交叉科学快报 2018年第4期2卷 93-102页

作者：秦宁闵清胡文祥湖北科技学院药学院，湖北咸宁北京神剑天军医学科学院京东祥鹄微波化学联合实验室，北京

生物钟在动物、植物等生物体内普遍存在，其对维持机体的行为、生理以及新陈代谢等方面起至关重要的作用。因此，本文结合2017年诺贝尔生理学或医学奖相关研究内容，从生物钟的定义及分类、生物钟运行的相关控制基因和生物钟异常引起的... 详细信息

生物钟在动物、植物等生物体内普遍存在，其对维持机体的行为、生理以及新陈代谢等方面起至关重要的作用。因此，本文结合2017年诺贝尔生理学或医学奖相关研究内容，从生物钟的定义及分类、生物钟运行的相关控制基因和生物钟异常引起的某些疾病及调节生物钟的航天牌眠尔康等四个方面进行概述。

关键词：生物钟昼夜节律基因航天牌眠尔康 biological clock Circadian Rhythm Gene Aerospace Brand Mianerkang

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