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2017中国长三角遗传学大会

Objective:Staphylococcus aureus is a widely-spread gram-positive pathogen causing endocarditis,osteomyelitis,pneumonia and food *** recent years,due to the large-scale use and abuse of antibiotics,Staphylococcus aureus resistance bacteria have been *** MRSA(methicillin resistant Staphylococcus aureus) to VISA(vancomycin resistant Staphylococcus aureus),Staphylococcus aureus resistant bacterias emerge very *** the cost of antibiotic research is high,the cycle is long,and it can not keep pace with the speed of bacterial *** is urgent to find new treatment methods for drug-resistant *** strains of phages named big phage and small phage of Staphylococcus aureus were isolated from the cattle farm in *** contain cow manure,washing water and *** research aims to study the classification and biological characterization and genome sequence of two bacteriophages and provide new idea for phage therapy of Staphylococcus ***:Two Staphylococcus aureus bacteriophages were isolated from the dairy farm environment by the standard strain ATCC25923 of Staphylococcus aureus,which is presented by laboratory teacher Conghui *** morphology and size of bacteriophages were observed by transmission electron microscope with negative *** pH and temperature stability were studied as well,the optimal multiplication of infection,the one-step growth curve,adsoution curve and infection curve were *** phage DNA were extracted for genome sequence and bioinformatics ***:Two phages were screened by Staphylococcus aureus ATCC25923,named big phage and small phage respectively,and were identified as Myoviridaeby transmission electron *** phage belongs to the family of Myoviridaeby with head diameter of about 95 nm,tail length of about230 nm and tail width of about 16 *** big phage genome is linear double-stranded DNA with a full-length 142.978 bp and a GC content of 29.799%.This pha

关键词： Staphylococcus aureus phage biological characterization genome sequence

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biological and biochemical characterization of a red-eye mutant in Nilaparvata lugens （Hemiptera： Delphacidae）

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Insect Science 2014年第4期21卷 469-476页

作者： Shu-Hua Liu Jing Yao Hong-Wei Yao Peng-Ling Jiang Bao-Jun Yang Jian Tang State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects Ministry of Agriculture College of Plant Protection Nanjing Agricultural University Nanjing Institute of Insect Sciences State Key Laboratory of Rice Biology Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Zhejiang University Hangzhou China

A red-eye colony was established in our laboratory in brown planthopper （BPH）, Nilaparvata lugens （Stal）, a major rice pest in Asia. Except for the red-eye phenotype, no other differences were observed between the wild-type （brown eye） and the mutant-type （red eye） in external characters. Genetic analysis revealed that the red-eye phenotype was controlled by a single autosomal recessive allele. biological studies found that egg produc- tion and egg viability in the red-eye mutant colony were not significantly different from those in the wild-type BPH. Biochemical analysis and electronic microscopy examination revealed that the red-eye mutants contained decreased levels of both xanthommatin （brown） and pteridine （red） and reduced number of pigment granules. Thus, the changes of amount and ratio of the two pigments is the biochemical basis of this red-eye mutation. Our results indicate that the red-eye mutant gene （red） might be involved in one common gene locus shared by the two pigments in pigment transportation, pigment granule formation or some other processes.

关键词： biological characterization eye pigment genetic analysis Nilaparvatalugens pigment granule red-eye mutant

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Circular RNAs in pulmonary hypertension:Emerging biological concepts and potential mechanism

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Animal Models and Experimental Medicine 2022年第1期5卷 38-47页

作者： Qian Wang Yuanyuan Sun Qinhua Zhao Wenhui Wu Lan Wang Yuqing Miao Ping Yuan Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Bismuth Science University of Shanghai for Science and Technology

Circular RNAs(circRNAs)are endogenous RNAs with a covalently closed single-stranded *** are a novel class of genomic regulators that are linked to many important development and disease processes and are being pursued as clinical and therapeutic *** the most powerful RNA sequencing and bioinformatics techniques,a large number of circRNAs have been identified and further functional studies have been *** is known that circRNAs act as potential biomarkers,sponges for microRNAs(miRNAs)and RNA-binding proteins(RBPs),and regulators of mRNA *** also participate in the translation of peptides or *** types of circRNAs are dysregulated in plasma or lung tissues,and they may be involved in regulating the proliferation and apoptosis of pulmonary artery endothelial cells(PAECs)and pulmonary artery smooth muscle cells(PASMCs),leading to pulmonary vascular remodeling in pulmonary hypertension(PH).One possible mechanism is that circRNAs can regulate the function of PAECs and PASMCs by acting as miRNA ***,other potential mechanisms of action of circRNAs are still being actively explored in *** paper presents a systematic review of the biogenesis,biological characterization,relevant underlying functions,and future perspectives for studies of circRNAs in the pathogenesis of PH.

关键词： biological characterization circular RNAs miRNA sponges pulmonary hypertension

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