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Chinese Chemical Letters 2024年第4期35卷 99-105页

作者： Tao Yu Vadim A.Soloshonok Zhekai Xiao Hong Liu Jiang Wang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China Department of Organic Chemistry Ⅰ Faculty of ChemistryUniversity of the Basque Country UPV/EHUSan Sebastian 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Lingang Laboratory Shanghai 200031China

Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties, which enable them to exhibit diverse biological activities such as anti-bacterial,anti-oxidant, anti-inflammatory, and anti-tumor properties. Furthermore, Schiff base metal complexes can serve as reagents and catalysts in chemical reactions. This review aims to provide an overview of our recently published studies on Cu(Ⅱ) and Pd(Ⅱ) complexes derived from proline Schiff base ligands. We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral resolution.

关键词： Schiff bases biological activity Tailor-made amino acids Asymmetric synthesis Chiral tridentate ligands Square-planar Cu(Ⅱ)-complexes Square-planar Pd(Ⅱ)-complexes

Progress in the preparation,identification and biological activity of walnut peptides

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未来食品学报(英文) 2024年第3期4卷 205-220页

作者： Chang Liu Zijie Zhang Yuting Shang Siting Li Junxi Xia Yiling Tian Yingmin Jia Aijin Ma School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Hebei Yangyuan ZhiHui Beverage Co. Ltd.Hengshui 053000China Institution of Chinese Walnut Industry Hengshui 053000China Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology Hengshui 053000China College of Food Science and Technology Hebei Agricultural UniversityBaoding 071000China

Walnuts are rich in protein and are a high-quality plant protein resource.In recent years,with the growth of consumer demand for functional food and food for special medical purpose,the use of walnut protein for the preparation of functional walnut peptide ingredients or additives and other compositions has received increasing attention.However,the improvement of the yield of walnut peptides and the clarification of their functional activities are the bottlenecks that limit the development of these peptides.To this end,this article reviews the pretreatment,preparation,purification and identification processes of walnut peptides,as well as their biological activities such as antioxidant activity,antitumour activity,improvement of memory,antihypertension and regulation of metabolic disorders are elaborated to provide a reference for the industrial development of walnut peptides.

关键词： Walnut Peptide Extraction Isolation Purification Identification biological activity

Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

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Applied Mathematics and Mechanics(English Edition) 2023年第5期44卷 823-840页

作者： J.Y.LIANG Wenjuan YAO Genomic Medicine Institute Lerner Research InstituteCleveland Clinic FoundationClevelandOH 44106U.S.A. Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200072China

Explaining the mechanism of the cochlear active phonosensitive amplification has been a major problem in medicine.The basilar membrane(BM)is the key infrastructure.In 1960,Nobel Laureate von B′ek′esy first discovered BM's traveling wave motion.Since that time,BM's models only have considered the traveling wave but not the biological activity.Therefore,a new model considering changes of BM's stiffness in space and time is established based on the immersed boundary method to describe its biological activity.It not only reproduces the results of traveling wave motion but also explains the mechanization on the generation of traveling wave.An important discovery is that changes of BM's stiffness in space and time will cause the unstable global resonance,which will induce amplification of sounds in cochlea.An important inference is that biological activity shall be included in the application of mechanical principles to the analysis of life,which is the essential difference between biomechanics and general mechanics.

关键词： basilar membrane(BM) biological activity mechanical analysis cochlear phonosensitive amplification

Structural diversity and biological activity of natural p-terphenyls

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Marine Life Science & Technology 2022年第1期4卷 62-73页

作者： Guoliang Zhou Tianjiao Zhu Qian Che Guojian Zhang Dehai Li Key Laboratory of Marine Drugs School of Medicine and PharmacyChinese Ministry of EducationOcean University of ChinaQingdao266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao266237China

p-Terphenyls are aromatic compounds consisting of a central benzene ring substituted with two phenyl groups,and they are mainly isolated from terrestrial and marine organisms.The central ring of p-Terphenyls is usually modified into more oxidized forms,e.g.,para quinone and phenols.In some cases,additional ring systems were observed on the terphenyl-type core structure or between two benzene moieties.p-Terphenyls have been reported to have cytotoxic,antimicrobial,antioxidant andα-glucosidase inhibitory effects.In this review,we will mainly summarize the structural diversity and biological activity of naturally occurring p-Terphenyls referring to the research works published before.

关键词： p-Terphenyl Marine organism Structure biological activity Cytotoxic

Chemistry,Biosynthesis,and biological activity of Halogenated Compounds Produced by Marine Microorganisms

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Chinese Journal of Chemistry 2022年第14期40卷 1729-1750,I0002页

作者： Jiamin Wang Xiaoyan Pang Chunmei Chen Chenghai Gao Xuefeng Zhou Yonghong Liu Xiaowei Luo CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of OceanologyChinese Academyof SciencesGuangzhouGuangdong 510301China Institute of Marine Drugs Guangxi University of Chinese MedicineNanningGuangxi 530200China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) GuangzhouGuangdong 511458China University of Chinese Academy of Sciences 19Yuquan RoadBejing 100049China

Natural products derived from marine microorganisms have been received great attention as a potential source of new compound entities for drug discovery.The unique marine environment brings us a large group of halogen-containing natural products with abundant biological functionality and good drugability.Meanwhile,biosynthetically halogenated reactions are known as a significant strategy used to increase the pharmacological activities and pharmacokinetic properties of compounds.Given that a tremendous increase in the number of new halogenated compounds from marine microorganisms in the last five years,it is necessary to summarize these compounds with their diverse structures and promising bioactivities.In this review,we have summarized the chemistry,biosynthesis(related halogenases),and biological activity of a total of 316 naturally halogenated compounds from marine microorganisms covering the period of 2015 to May 2021.Those reviewed chlorinated and brominated compounds with the ratio of 9:1 were predominantly originated from 36 genera of fungi(62%)and 9 bacterial strains(38%)with cytotoxic,antibacterial,and enzyme inhibitory activities,structural types of which are polyketides(38%),alkaloids(27%),phenols(11%),and others.This review would provide a plenty variety of promising lead halogenated compounds for drug discovery and inspire the development of new pharmaceutical agents.

关键词： Marine microorganisms Natural products Halogenated compounds biological activity Biosynthesis

biological activity and Antibacterial Property of Nano-structured TiO_2 Coating Incorporated with Cu Prepared by Micro-arc Oxidation

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Journal of Materials Science & Technology 2013年第3期29卷 237-244页

作者： Wei Zhu Zhenxiang Zhang Beibei Gu Junying Sun Lixian Zhu Orthopedic Department The First Affiliated Hospital of Soochow University Orthopedic Department Orthopedic DepartmentThe Affiliated Taizhou People's Hospital of Nantong University

Micro-arc oxidized Cu-incorporated TiO2 coatings （Cu-TiO2） were prepared in the Ca, P, Cu-containing electrolyte to obtain an implant material with superior biological activity and antibacterial property. The surface topography, phase, and element composition of the TiO2 and Cu-TiO2 coatings were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, and energy-dispersive X-ray spectrometry （EDS）, respectively. Staphylococcus aureus （S. aureus） was selected to evaluate the antibacterial property of the Cu-TiO2 coatings, whereas osteoblastic MG63 cells were cultured on the coatings to investigate the biological activity. The obtained results demonstrated that Cu element was successfully incorporated into the porous nano-structured TiO2 coatings, which did not alter apparently the surface topography and phase composition of the coatings as compared to the Cu-free TiO2 coatings. Moreover, the antibacterial studies suggested that the Cu-incorporated TiO2 coatings could significantly inhibit the adhesion of S. aureus. In addition, the in vitro biological evaluation displayed that the adhesion, proliferation and differentiation of MG63 cells on the Cu-incorporated coatings were enhanced as compared to those on the Cu-free coatings and Ti plates. In conclusion, the innovative Cu-incorporated nano-structured TiO2 coatings on Ti substrate with excellent antibacterial property and biological activity are promising candidates for orthopedic implant.

关键词： Micro-arc oxidation Copper biological activity Antibacterial property

Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second example of c-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation biological activity Apoptosis Nasopharyngealcarcinoma

Bioactive Hydrogels with Pro-coagulation Effect for Hemostasis

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Chinese Journal of Chemistry 2024年第1期42卷 87-103,I0004页

作者： Quanshi Guo Yihang Ding Lisha Yu Zongrui Tong Zhengwei Mao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310058China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province HangzhouZhejiang 310009China

Hemostatic hydrogels are widely applied for wound management of damaged tissues,traumatic wounds,and surgical incisions.Some hydrogels composed of bioactive components,including fibrin and thrombin,showed great promise in the clinic due to their good pro-coagulation effect.With the expanding knowledge of cascade reaction of blood coagulation and emerging bioactive substances,massive bioactive hydrogels consisting of peptides,hemocoagulase,polyphosphate(polyP),etc.,have been developed as effective hemostatic materials.Based on the coagulation process and mechanism,we summarize the role of reported bioactive hydrogels in hemostasis in this review.We conclude the key points in the coagulation process,including activation of coagulation factors,fibrinogen polymerization,etc.,then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these points.Finally,we conclude the progress and propose a perspective of bioactive hydrogels with a pro-coagulation effect for hemostasis.

关键词： Hemostasis biological activity Biomaterials Enzyme catalysis Composites

Two Observed Regions in B Lymphocyte Stimulator Important for Its biological activity

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Acta Biochimica et Biophysica Sinica 2006年第4期38卷 227-232页

作者： Qiong SHEN~(1,2) Su-Xia LI~1 Fei-Hao FU~1 Qin-Sheng YUAN~1* Yi GONG~2* 1 State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China 2 Research Center of Biotechnology,Shanghai Institutes for biological Sciences,Chinese Academy of Sciences,Shanghai 200233,China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237 China Research Center of Biotechnology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200233 China

B lymphocyte stimulator （BLyS）,a member of the tumor necrosis factor superfamily ofligands,is a crucial survival factor for B cells.We successfully constructed seven mutants of the functionalsoluble fragment of human BLyS （named cBLyS,amino acid 134-285）,including three deletion mutants andfour site-directed mutants.All the mutant proteins were expressed in Escherichia coli and purified by Ni-NTA affinity chromatography.The biological activities of these mutants were assessed by the ligand-recep-tor binding assay,B cell proliferation assay and immune effect response in vivo.Our results indicated thatfour residues,H218,F220,T228and L229,are indispensable for the biological activity of cBLyS,whereas tworegions,amino acid 134-148 and amino acid 271-285,are related to the biological activity of BLyS.Theprotein of deletion of amino acid 134-148 leads to a complete defection in raising the antigen-specific IgMtiter.The deletion of amino acid 271-285 reduces the effectiveness compared with the native cBLyS.Thisindicates that the region of amino acid 134-148 is indispensable for cBLyS to function normally.

关键词： B lymphocyte stimulator (BLyS) deletion mutant biological activity

Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira Paula Oreiro-Martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are surveyed.This review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also summarized.Porphyrin and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than nitrogen.The synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality biological activity Molecule magnet