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The Yin and Yang of the protein corona on the delivery journey of nanoparticles

Nano Research 2023年第1期16卷 715-734页

作者： Yi-Feng Wang Yaxin Zhou JiaBei Sun Xiaotong Wang Yaru Jia Kun Ge Yan Yan Kenneth A.Dawson Shutao Guo Jinchao Zhang Xing-Jie Liang Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapythe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China China National Institute of Food and Drug Control Beijing 100061China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Centre for BioNano Interactions School of ChemistrySchool of Biomolecular and Biomedical ScienceUniversity College DublinDublin D04V1W8Ireland

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled ***,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in *** challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological ***,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the *** protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate ***,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery *** this review,we first summarize the fundamental impact of the protein corona on the delivery journey of ***,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in ***,we highlight what we need to do as a next step towards better understanding and exploitation of the protein *** hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.

关键词： protein corona nanoparticles biological identity drug delivery bio-nano interaction

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