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Syntheses of Fe-Ni Magnetic Nanoparticles and Their Applications on biologic labeling

Syntheses of Fe-Ni Magnetic Nanoparticles and Their Applicat...

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中国颗粒学会2006年年会暨海峡两岸颗粒技术研讨会

作者： Ming-Fong Tai Jong-Kai Hsiao Yi-Fong Chou Kuo-Chih Wang Bor-Zin La Shin-Tai Chen Department of Optoelectronic System Engineering Minghsin University of Science and Technology HsinchuChina Department of Medical Imaging Taiwan University Hospital and College of Medicine TaipeiChina Department of Electronic Engineering WeFeng Institute of Technology ChiayiChina Department of Electric Engineering WeFeng Institute of Technology ChiayiChina Musculoskeletal Disease Center J.L.Pettis VA Medical Center Loma Linda CA 92357USA Department of Biochemistry Loma Linda University Loma Linda CA 92357 USA

In this study, we compared FeNi alloy magnetic nanoparticles (MNPs) prepared by either combustion or chemical precipitation methods. We found that the FeNi MNPs generated by combustion method have a rather high saturation magnetization Ms of -180 emu/g and a coercivity field Hc of near zero. However, the alloy nanoparticles are easily aggregated and are not well dispersive such that size distribution of the nanoparticle clusters are wide and clusters are rather big (around 5000 nm). To prepare a better quality and well dispersed Fe-Ni MNPs, we also developed a thermal reflux chemical precipitation method to synthesize FeNi3 alloy MNPs. The precursor chemicals of Fe(acac)3 and Ni(acac)2 in a molecular ratio of 1:3 reacted in octyl ether solvent at the boiling point of solvent (00 ℃) by the thermal reflux process. The 1,2-hexadecandiol and tri-n-octylphosphine oxide (TOPO) were used as reducer and surfactant, respectively. The chemically precipitated FeNi3 MNPs are well dispersed and have well-controlled particle sizes around 10-20 nm with a very narrow size distribution (±1.2 nm). The highly monodispersive FeNi3 NPs present good uniformity in particle shape and crystallinity on particle surfaces. The MNPs exhibit well soft magnetism with saturation magnetization of -61 emu/g and Hc. The biomedical compatible FeNi MNPs which were coated with biocompatible polyethyleneimine (PEI) polymer were also synthesized. We demonstrated that the PEI coated FeNi MNPs can enter the mammalian cells in vitro and can be used as a magnetic resonance imagine (MRI) contrast agent. The results demonstrated that FeNi MNPs potentially could be applied in the biomedical field. The functionalized magnetic beads with biocompatible polymer coated on MNPs are also completed for biomedical applications.

关键词： magnetic nanoparticles Fe-Ni alloy chemical precipitation method biologic labeling

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