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Sonodynamic cancer therapy by novel iridium-gold nanoassemblies

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Chinese Chemical Letters 2022年第4期33卷 1907-1912页

作者： Jiayi Zhu Ai Ouyang Zhuanglin Shen Zhihao Pan Samya Banerjee Qianling Zhang Yantao Chen Pingyu Zhang College of chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Department of chemistry Indian Institute of Technology(BHU)VaranasiUP 221005India

Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic performance.But,low in-depth tissue penetration of light limits their effectivity for deeply buried tumors.Encouraged by the sonosensitizing ability of the traditional organic photosensitizers,here,we developed AuNPs@Ir1 as a sonosensitizer by hybridizing an organometallic Ir(Ⅲ) complex(Ir1) with ultrasmall gold nanoparticles(AuNPs) for efficient tumor sonodynamic therapy(SDT) for the first time.AuNPs@Ir1 rapidly entered the cancer cells,produced ^(1)O_(2),and catalytically oxidized NADH to NAD;under ultrasound(US)irradiation,thus resulted in cancer cells oncosis.Because of efficient passive retention in tumors post intravenous injection,AuNPs@Ir1 further efficiently inhibited the growth of tumors in-vivo under US stimulation without long-term toxicity to other organs.Overall,this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel AuNPs@Ir1.It is expected to increase the scope of SDT for metal-based anticancer drugs.

关键词： Metals in medicine Iridium complex Sonocatalysis Sonodynamic therapy bioinorganic chemistry

Biological Function of REE in Plants & Microbes

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Journal of Rare Earths 2005年第6期23卷 645-652页

作者：邱关明李伟李喜坤周威 School of Materials and Engineering Changchun University of Science and Technology Changchun 130022 China Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Nanjing University of Technology Nanjing 210009 China Institute of Genetic Rescourses College of Life Science Nanjing Normal University Nanjing 210097 China Institute

Rare earth elements （REE） and their compounds years. The bioinorganic chemical research of REE during the are widely applied in agronomic and medical fields for many past few years indicates that REE play important roles in the promotion of photosynthetic rate as well as root absorption, regulation of hormone and nitrogen metabolism, and suppression of microbes, etc. The metallic or non-metallic targets of key biomolecule in various physiological processes can be chosen by REE for the chelation or replacement, which enables REE to regulate the biological functions or behaviors of those biomolecule and consequently leads to significant embodiment of biological function of REE in plants and microbes. Overdose of REE, however, shows an inhibitory effect on living organisms. Therefore, this paper proposes two suggestions that will be available in the extension of full use of REE＇s biological function. One is to obey the dose law of REE and control REE concentrations within a safe range. The other is to further test the bioaccumulation and long-period influence of REE on organisms.

关键词： bioinorganic chemistry biological function of REE plants and microbes dosage effect bioaccumulation rare earths

Biological Intelligence of Rare Earth Elements in Animal Cells

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Journal of Rare Earths 2005年第S1期23卷 554-573页

作者：邱关明李伟李喜坤周威杨春生 Changchun University of Science and Technology Changchun 130022 China Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Shenyang Ligong University Shenyang 110168 China Yancheng Institute of Technology Yancheng 224003 China

Recent progress in bioinorganic chemistry studies of rare earth elements (REE) in animal cells was outlined, and the definition of REE′s biological intelligence as well as their mechanism were also explained. The migration of REE from weathering rocks to the environment is accelerated by various anthropogenic activities, which can eventually result in the entrance of REE into animal and human bodies via food chain. REE can be found in body tissues such as brain, blood, muscle as well as bone. Based on their geochemical properties, REE in low dose show their unique biological intelligence by intervening in the process of signal transduction and its regulation, arteriosclerosis and blood clotting prevention, anticancer, and the promotion of cellular defense enzymes′ activities, nucleic acid metabolism enzymes as well as ATPases, etc. The meaning of REE′s biological intelligence refers to physicochemical properties-based capability to choose the targets (e.g., biometals) in biomolecules for the chelation or replacement of REE, and change the structures and functions of biomolecules, and consequently impact or control the biological functions or behaviors in living organisms. The regulation of various cellular processes caused by REE is mainly via antagonism or replacement of essential target biometals like calcium or via chelation of organic molecules, thereby embodying the unparalleled biological intelligence of REE. Additionally, the dosage effect of REE was also discussed from the angles of yin-yang dichotomy, bioavailability, entropy and evolution. In order to make full use of REE′s biological intelligence in the application for medicine, more detailed studies concerning dosage effect of REE and REE bioaccumulation in organisms should be conducted in future research.

关键词： bioinorganic chemistry biological intelligence of REE animal cells replacement antagonism target biometals evolution dosage effect bioaccumulation rare earths

Preparation, Structure and Electrochemical Property of a Pyrazole-substituted Diiron Dithiolate Complex

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Chinese Journal of Structural chemistry 2012年第11期31卷 1650-1656页

作者：冯亚南陈瑞平李志华杜少武 State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences

A pyrazole-substituted diiron dithiolate complex [Fez（p-pdt）（CO）5（3,5-Me2Pz）] （1, 3,5-MezPz = 3,5-dimethylpyrazole） was prepared as a biomimetic model for the active site of [FeFe]-hydrogenase by CO-substitution of aU-carbonyl complex [Fe2（μ-pdt）（CO）6] with 3,5-Me2Pz. The molecular structure was confirmed by MS, IR, 1H NMR, elemental analysis and single-crystal X-ray analysis. Complex 1 crystallizes in the triclinic system, space group PI with a = 9.108（7）, b = 9.743（8）, c = 11.192（9）A, a = 109.235（5）, fl = 101.914（9）, y = 96.605（6）. In CH3CN solution, reversible transformation between 1 and the acetonitrile-substituted species [Fe2（p-pdt）- （CO）5（NCCH3）] was detected by both IR and cyclic voltammetry （CV）. The electrochemical proton reduction catalyzed by 1 in the presence of acetic acid was also studied in CH2C12.

关键词： bioinorganic chemistry [FeFe]-hydrogenase substitution proton reduction

A New Pyridine-substituted Azadithiolate 2Fe2S Complex Related to the Active Site of[FeFe]-hydrogenase

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Chinese Journal of Structural chemistry 2016年第2期35卷 237-245页

作者： XU Fen-Fen FENG Ya-Nan DU Shao-Wu CHEN Yi-Feng No.2 Middle School of Nanchang Jiangxi 330006China State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

A new 2Fe2 S complex[（2-C5H4N）N（μ-CH2S）2Fe2（CO）6]（1） related to the active site of[FeFe]-hydrogenase was obtained by treating（HS）2Fe2（CO）6 with（pyridin-2-ylazanediyl）dimethanol.Protonation occurred at the pyridine nitrogen atom when two equivalents of HBF4·OEt2acid were added to the toluene solution of 1,leading to the formation of[（2-C5H4NH）N（μ-CH2S）2Fe2（CO）6]·BF4·OEt2（1H~＋）,whose molecular structure was further established by singlecrystal X-ray analysis.Complex 1 crystallizes in the monoclinic system,space group P21/n with α=7.728（3）,b = 11.825（4）,c = 17.888（6） A,β= 92.968（5）°,while complex 1H~＋ crystallizes in the triclinic system,space group P1 with a = 7.672（4）,b = 10.382（5）,c = 16.480（10） A,α=106.575（13）,β= 93.18（3）,γ=104.262（17）°.

关键词： bioinorganic chemistry [FeFe]-hydrogenase protonation proton reduction

Iron and Oxygen chemistry in Nature’s Nanocage Proteins,the Ferritins

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Iron and Oxygen Chemistry in Nature’s Nanocage Proteins,the...

Cyclometalated iridium（Ⅲ） complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

中国化学会第26届学术年会化学生物分会场

作者： Elizabeth C. Theil Takehiko Tosha CHORI Children’s Hospital Oakland Research Institute and the Dept. of Nutr. ＆ Tox. University of California-Berkeley CHORI Children’s Hospital Oakland Research Institute and the Dept. of Nutr. ＆ Tox. University of California-Berkeley

Diferric oxo/hydroxo mineral precursors are synthesized from Fe（II） and dioxygen substrates at multiple, Fe（II）/O2 oxidoreductase sites in the ferritin protein nanocage. Hydrated ferric oxide minerals form in the ferritin protein nanocage by catalytic coupling reactions, vectorial transport through the protein to the nanocage cavity, and hydrolysis in the cavity;mineral size is up to 4500 Fe, 9000 O and 4500 H atoms [ferrihydrate: Fe2O3.H2O/ FeOOH)] and variable phosphate. The iron biominerals have two biological functions: 1. concentrating iron for the biosynthesis of Fe-protein centers, a critical function based on the lethality of gene deletion, and 2. minimizing free radical chemistry and inflammation, by moving Fe （II） and O2 from the cell cytoplasm to the mineral. We will describe our studies on identifying amino acids and their function at the ferritin Fe（II）/O2 oxidoreductase catalytic site, where the first detectable reaction product, diferric peroxo, is also formed by di-iron cofactors and dioxygen in oxygenases e.g., methane monooxygenase and ribonucleotide reductase. In addition, we will discuss possible mechanisms for recovering Fe（II） from the ferritin nanocage, through gated protein pores, using reductants （NADH/FMNH）, chelators and peptides that bind selectively to ferritin and alter pore folding/unfolding in analogy to peptide-regulated ion channel protein pores. The results increase understanding of protein catalysis, protein pores, regulated protein folding/unfolding, human iron absorption from ferritin in natural foods （soy, lentil, etc）, medical management of transfusional iron overload or inflammation, and biomineralization. Support: NIH: ECT, XSL, TT), Cooley’s Anemia Foundation （XSL）, JSPS （Japan Society for the Promotion of Science）（TT）.

关键词： Ferritin iron oxide nanoparticle Fe（II）/O2 oxidoreductase protein pore gating bioinorganic chemistry

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Cyclometalated iridium（Ⅲ） complexes as lysosome-targeted ...