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Correlation of Abortus Imminence Cases in the First Trimester with biochemical markers

Open Journal of Obstetrics and Gynecology 2023年第2期13卷 207-213页

作者： Küçükyurt Ayça Kubat Basat Dilara Bingöl Bugra Berkan Artuğ Cansızlar Gülnihal İlhan Gülşah Istanbul Research and Education Hospital Obstetrics and Gynecology Istanbul Türkiye Bossan International Hospital Istanbul Türkiye

Objective: In this study, we compared the biochemical markers of imminent abortion, missed abortion, and healthy pregnant women in the first trimester to see if there were any differences. Materials and Methods: The study method is prospective. Pregnant women who applied to the obstetrics clinic of Istanbul Training and Research Hospital between 01.04.22 and 31.10.22 were diagnosed with abortion imminens or missed abortion between 6 weeks and 12 weeks or had normal pregnancy follow-up, had no chronic diseases, and did not take magnesium and calcium supplements were included in the study. 20 pregnant women with missed abortion, 20 pregnant women with abortion imminens diagnosis and 20 normal pregnant women who met the criteria were included in the study. Magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn) and hemogram (CBC) levels were checked in pregnant women included in the study. Results: The Mg, Cu, Zn, and CBC values of the study participants’ women did not differ in a statistically significant way. When compared to pregnant women who had a normal pregnancy process, the difference in Ca value was found to be statistically substantially smaller in pregnant women who were diagnosed with abortion imminens and missed abortion. The findings of our study suggest that serum Ca levels be measured prior to conception or at the initial visit. Conclusion: Serum Ca levels were found to be significantly lower in the missed abortion group than in the abortus imminens and normal pregnant groups in our study (p 0.05).

关键词： Abortion biochemical markers Calcium Copper Magnesium Missed Abor-tion Spontaneous Abortion Zinc

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第4期10卷 320-335页

作者： Joaquim Castro Silva Patricia Tavares Rita Ferreira Lucio Lara Santos Eurico Monteiro Instituto Portuguê s de Oncologia do Porto Francisco Gentil Porto Portugal LAQV Department of Chemistry University of Aveiro Aveiro Portugal

Cachexia is a multifactorial syndrome related to unintentional weight loss and to loss of muscle and fat mass. In head and neck cancer (HNC) its incidence is important and not only related to a deficient intake of food due to the impact of the disease in the vital functions. A complex disturbance in the normal metabolism of the patient promotes a persistent inflammatory state and a shifting in the metabolism balance toward a catabolic predominance affecting primarily the skeletal muscle. This leads to severe impairment of the functional, emotional and social status and quality of life of the patients that will compromise response to treatment and the disease prognosis. Understanding this deleterious syndrome and mainly identifying it in early stages of the disease is of a major importance in achieving better outcomes to head and neck cancer patients. This study pretends to identify clinical aspects related to cachexia in HNC in a clinical perspective for application on the routine clinical practice. In our study, 30 HNC patients were enrolled and evaluated in terms of nutritional values (actual and loss of weight in the past 6 months, body mass index (BMI), nutritional risk index (NRI), malnutrition universal screening tool), serum biochemical markers (albumin, total proteins, cholesterol, triglycerides, urea, C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and myostatin) and health related quality of life (HRQoL) evaluation (using European Organisation for the Research and Treatment of Cancer (EORTC) quality of life questionnaires (QLQ): EORTC QLQ-C30 and EORTC QLQ-HN43). A minimum follow-up of 48 months was considered for all patients. Our results showed that NRI is a good and sensitive index to identify cachexia. This index uses two parameters, one constitutional (loss of weight) and one biochemical (level of serum albumin). According to this criterion, 16 patients were assigned to the No-cachexia group and 14 patients to the Cach

关键词： Cachexia Head Neck Cancer Quality of Life biochemical markers Malnutrition

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Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-Xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

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Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

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American Journal of Molecular Biology 2024年第3期14卷 126-137页

作者： Irié Lou Bohila Emilie Kamo Kouakou Serge Kouassi Virginie Atto Allico Joseph Djaman Jean David N’guessan Mireille Dosso Department of Microbiology Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire Biology and Health Laboratory Flix Houphout-Boigny University Abidjan Cte dIvoire Department of Medical and Fundamental Biochemistry Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire

Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311 HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

关键词： Terminalia mantaly Bio Cardiac Tolerance biochemical markers Histopathology

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Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 78-86页

作者： Ambreen Mehmood Awan Wafa Majeed Faraza Javed Bilal Aslam Asra Iftikhar Hafiza Arooj Kanwal Sobia Fiaz Institute of Physiology and Pharmacology University of AgricultureFaisalabadPakistan Department of Pharmacology Faculty of Pharmacythe Islamia University of BahawalpurBahawalpurPakistan Department of Pharmacy University of FaisalabadFaisalabadPakistan Department of Pharmacy University of AgricultureFaisalabadPakistan

Objective:To explore the protective role of Glinus lotoides ethanolic extract in a depression model through modulating oxidant/antioxidant enzyme system and inflammatory ***:Phytochemical constituents of Glinus lotoides ethanolic extract were evaluated qualitatively and quantitatively along with *** were divided into six *** normal control and the intoxicated groups received normal saline,and the standard group received imipramine,while the remaining groups received 100,300,and 500 mg/kg Glinus lotoides ethanolic *** groups received treatments for 14 ***(LPS)were then administered i.p.(0.83 mg/kg)to all groups except the normal control *** 24 h,anxiety and depression-like behaviors were evaluated by performing behavioral analysis(open field,tail suspension,forced swim,sucrose preference test),and determining total oxidant status,total antioxidant capacity,catalase,and biochemical parameters[malondialdehyde,glutathione,superoxide dismutase,tumor necrosis factor(TNF)-alpha and interleukin(IL)-6].Results:Phytochemical studies confirmed the presence of phenols and flavonoids and HPLC analysis showed the presence of gallic acid,quercetin,chlorogenic,and caffeic *** oxidant status was significantly decreased,while total antioxidant capacity was significantly increased in the Glinus lotoides ethanolic extract treated ***,Glinus lotoides ethanolic extract diminished malondialdehyde,IL-6,and TNF-alpha levels,while increasing superoxide dismutase,catalase,and glutathione ***:Glinus lotoides ethanolic crude extract shows significant antidepressant activity by modulating oxidative and biochemical parameters that supports its folkloric use in traditional systems of medicine.

关键词： Glinus lotoides biochemical markers Depression Traditional medicine Nervous system Anxiety Antioxidant Inflammation

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Multisystem Inflammatory Syndrome-Neonate: biochemical Parameters as Early Marker of Adverse Neurodevelopmental Outcome

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Open Journal of Pediatrics 2022年第5期12卷 767-782页

作者： Perumalsathya Sankaranarayanan Harshitha Shanmuganathan Devika Sanil Kumar Lal Devayani Vasudevan Nair Santosh Kamalakannan Department of Pediatrics Saveetha Medical College and Hospital Chennai India Department of Research and Development Saveetha Medical College and Hospital Chennai India Department of Neonatology Saveetha Medical College and Hospital Chennai India

Background: Pregnant women and newborns are highly susceptible to Covid-19, manifesting as multisystem inflammatory syndrome-New-born (MISC-N) in many babies born to Covid positive mothers. The relationship between Covid-19 infection during pregnancy and neonatal neurodevelopmental outcome, if any, is unclear necessitating a follow-up study in this aspect. Methods: 16 babies with MIS-N, born to symptomatic Covid antibody positive mothers were enrolled. Demographic profile, treatment details and biochemical parameters were analyzed with neurodevelopmental follow-up. Results: 25% mothers received 2 doses of Covid vaccine;50% had oligohydramnios and 75% received antenatal steroids. 87.5% were preterm of which 62.5% required surfactant with ventilator support and 75% required ionotropic support. Significant association was found between the antibody level and D-dimer levels with the ferritin and LDH levels of the baby (p 0.05);gestational age with LDH and D-dimer levels (p 0.05) and Covid antibody level of the baby vs the duration of ventilator requirement (P-value-0.0009). D-dimer values of babies were positively associated with both maternal antibody and D-dimer levels. Neurodevelopmental follow-up done at 6 months of corrected gestational age showed 37.5% were normal, 37.5% hypertonic and 25% hypotonic. HINE score was below 60 in 62.5%. Development assessment using Bayley-III showed a delay in the motor domain (62.5%), cognitive domain (56.25%) and language domain (62.5%). Conclusion: Neurodevelopmental problems occur in babies born to Covid positive mothers and should be stratified as “high risk”. Anticipatory guidance to prospective mothers for preterm care should be given. Covid antibody titre and D-dimer levels may help to predict the NICU stay, ventilator requirement and the adverse neurodevelopmental outcomes in these babies.

关键词： Neurodevelopment Covid-19 Pregnancy Multisystem Inflammatory Syndrome biochemical markers D-Dimer HINE Score

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Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

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Neuroscience Bulletin 2017年第5期33卷 535-542页

作者： Weidong Le Jie Dong Song Li Amos D. Korczyn Liaoning Provincial Center for Clinical Research on Neurological Diseases The First Affiliated HospitalDalianMedical UniversityDalian 116021China Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated HospitalDalian Medical UniversityDalian 116021China Collaborative Innovation Center for Brain Science The First Affiliated HospitalDalian Medical UniversityDalian 116021China Department of Neurology Sackler School of MedicineTel Aviv University69978 Ramat-AvivIsrael

Parkinson＇s disease （PD） is a complex neurode- generative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients, there is an urgent need to identify sensitive and specific biomarkers. Biomarkers can be divided into four categories： clinical, imaging, biochemical, and genetic. Ideal biomarkers not only improve our under- standing of PD pathogenesis and progression, but also provide benefits for early risk evaluation and clinical diagnosis of PD. Although many efforts have been made and several biomarkers have been extensively investigated, few if any have been found useful for early diagnosis. Here, we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.

关键词： Parkinson's disease· Biomarker Early diag-nosis - Molecular imaging biochemical markers

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Biotolerance Study of the Hydroalcoholic Extract of Terminalia mantaly H. Perrier on Rat Renal Activity

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Journal of Biosciences and Medicines 2022年第12期10卷 167-179页

作者： Kamo Irié Lou Bohila Emilie Tra Bi Irie Otis Kouassi Kouakou Serge Djaman Allico Joseph N’guessan Jean David Department of Microbiology Institut Pasteur of C&ocirc te d’Ivoire Abidjan C&ocirc te d’Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocirc te d’Ivoire Abidjan C&ocirc te d’Ivoire Superior Normal School Abidjan C&ocirc te d’Ivoire Biology and Health Laboratory Félix Houphou&euml t-Boigny University Abidjan C&ocirc te d’Ivoire Biology and Health Laboratory Félix Houphou?t-Boigny University Abidjan C&ocirc te d’Ivoire

Terminalia mantaly H. Perrier is one of the plants of the Combretaceae family that is widely used in traditional African medicine for its antibacterial, antifungal, and especially in the treatment of malaria. In this study, we evaluated the effect of the hydroalcoholic extract of Terminalia mantaly (HAETM) on the tissue and kidney biochemical markers of rats. Forty (40) rats were randomly divided into 4 groups, assigning 10 animals within each group (5 males and 5 females per group). Animals in group 1 received distilled water and were used as the control group;on the other hand, groups 2, 3, 4 received by gavage a volume of the extract corresponding to 1 ml/100g body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The hydroalcoholic extract was administered at the same time daily for 28 days, and blood was collected once a week to evaluate renal biochemical parameters;the kidney tissues were used to perform the histopathological study. The creatinine rate increased significantly (p Terminalia mantaly should be globally well tolerated by the body when used in doses ranging from 150 to 600 mg/kg of the body weight in animals (for this study, rats). However, further in-depth studies would be needed to get a more thorough and complete picture of the safety profile of the extract.

关键词： Terminalia mantaly Biotolerance biochemical markers

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Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline:an overview

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Chinese Medical Journal 2004年第2期17卷 291-295页

作者： Baris Simsek zgülKaracaer inci Karaca Department of Oral and Maxillofacial Surgery Faculty of Dentistry University of Gazi Emek Ankara TurkeyDepartment of Oral and Maxillofacial Surgery Faculty of Dentistry University of Gazi Emek Ankara TurkeyDepartment of Prosthodontics Faculty of Dentistry University of Gazi Emek Ankara Turkey

Purpose The purpose of this study is to review the urine products of bone breakdown as markers of bone resorption and usefulness of urinary hydroxyproline.Data Related researches published in 1985 -2000 were systematically reviewed.Results Bone markers could be used for early diagnosis of bone metabolic diseases. biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism. Assessment of bone resorption can be achieved with measurement of urinary hydroxylysine glycosides, urinary excretion of the collagen pyridinium cross-links, urinary excretion of type I collagen telopeptide breakdown products (cross-linked telopeptides) and urinary hydroxyproline.Conclusion Urinary hydroxyproline has been in use as a marker of bone resorption, but it lacks sensitivity and specificity. It is a modified aminoacid that is a metabolic product of collagen breakdown. Hydroxyproline may be released either free or with fragments of the collagen molecule attached during bone resorption, and it is also liberated by the breakdown of complement and nonskeletal collagen.

关键词： bone resorption marker biochemical markers hydroxyproline collagen breakdown hydroxylysine glycosides pyrolidine deoxypyrolidine N-tebpeptides C-telopeptides

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The Effect of Glucosamine and Chondroitin Sulfate on Chondromalacia Patellar in Sports People——A Systematic Review

The Effect of Glucosamine and Chondroitin Sulfate on Chondro...

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中国营养学会第十五届全国营养科学大会

作者： Huizhen Hao Jianmin Cao Beijing Sport University

Chondromalacia patellae(CMP), a type of osteoarthritis, is the most common progressive joint disease diagnosed and its treatment continues to be a significant *** initial pathological changes include chondromalacia, swelling, and edema. CMP is caused by a variety of factors, including increased cartilage vulnerability, trauma, patellofemoral instability, bony anatomical variations, abnormal patellar kinematics, and occupational hazards. CMP may be reversible and in severe cases, may also develop into patellofemoral osteoarthritis. Therefore, for sports people with knee injuries, early prevention and treatment can reduce the *** pathology have a negative impact on the quality of people’s *** goals of CMP treatment are to reduce pain, improve function and quality of life, and reduce the incidence of disability. There are many treatment methods for CMP, among which conservative treatment is the most popular treatment *** conservative therapy, compounds such as glucosamine and chondroitin sulfate are considered supplements to the drugs needed to treat the disease. Therefore, in recent years, the role of such drugs in the treatment of chondromalacia patellae has been extensively studied. After research, glucosamine and chondroitin sulfate treatment has gradually become a common *** is one of the most abundant monosaccharides in the human body. Studies have shown that glucosamine can promote the production of hyaluronic acid. Some animal studies have shown that dietary supplementation with chondroitin sulfate prevents the degeneration of articular cartilage, and it is added to certain animal feeds. This protective effect is associated with the anti-inflammatory and immunomodulatory activities of chondroitin sulfate. In addition, glucosamine and chondroitin sulfate inhibit the expression of several cytokines that affect cartilage catabolism, and the combined action of the two produces a synergistic effect of regulating articular car

关键词： glucosamine chondroitin sulfate chondromalacia patellar biochemical markers

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