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Advances in clinical applications of bioceramics in the new regenerative medicine era

World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： Noha Elshazly Fayza Eid Nasr Ayat Hamdy Safa Saied Mohamed Elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt Department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and electrospinning.The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic properties.All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds.Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers.The results were promising and opened new frontiers for utilizing these materials on a larger scale.The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration.Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties.All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine bioceramics Chronic wounds Bone defects Clinical applications

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Li-Mg-Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration

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Bioactive Materials 2023年第10期28卷 227-242页

作者： Yiting Sun Hongjian Zhang Yu Zhang Zheqi Liu Dongming He Wanlin Xu Siyi Li Chenping Zhang Zhen Zhang Department of Oral&Maxillofacial-Head&Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai200011China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai200011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

Biomaterials can modulate the local immune and repair-supportive microenvironments to promote peripheral nerve regeneration. Inorganic bioceramics have been widely used for regulating tissue regeneration and local immune response. However, little is known on whether inorganic bioceramics can have potential for enhancing peripheral nerve regeneration and what are the mechanisms underlying their actions. Here, the inorganic lithium-magnesium-silicon (Li-Mg-Si, LMS) bioceramics containing scaffolds are fabricated and characterized. The LMS-containing scaffolds had no cytotoxicity against rat Schwann cells (SCs), but promoted their migration and differentiation towards a remyelination state by up-regulating the expression of neurotrophic factors in a β-catenin-dependent manner. Furthermore, using single cell-sequencing, we showed that LMS-containing scaffolds promoted macrophage polarization towards the pro-regenerative M2-like cells, which subsequently facilitated the migration and differentiation of SCs. Moreover, implantation with the LMS-containing nerve guidance conduits (NGCs) increased the frequency of M2-like macrophage infiltration and enhanced nerve regeneration and motor functional recovery in a rat model of sciatic nerve injury. Collectively, these findings indicated that the inorganic LMS bioceramics offered a potential strategy for enhancing peripheral nerve regeneration by modulating the immune microenvironment and promoting SCs remyelination.

关键词： Peripheral nerve regeneration bioceramics Immuno-modulation microenvironment Macrophage Nerve guidance conduit

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bioceramics utilization for the repair of internal resorption of the root:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11185-11189页

作者： Abdullah Mahmoud Riyahi Department of Restorative Dental Science King Saud UniversityRiyadh 11545Saudi Arabia

BACKGROUND The objective of this work is displaying a successful treatment for an internal resorption case under operating microscope using bioceramic material.CASE SUMMARY Periapical radiograph showed radiolucent lesion representing large internal resorption of the root.The respective defect was obturated using endoscquence bioceramic material follow up at the month 18 after treatment revealed no abnormal finings clinically and radiographically.CONCLUSION New generations bioceramics have many advantages that internal root resorption cases can benefit from.The use of operating microscope helps to apply obturating materials with precision.However,long term study on a large sample is required in future studies.

关键词： Resorption Root Treatment Internal bioceramics Endodontics Case report

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Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds

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Bioactive Materials 2020年第2期5卷 309-317页

作者： Ya.Yu Filippov E.D.Orlov E.S.Klimashina P.V.Evdokimov T.V.Safronova V.I.Putlayev J.V.Rau Department of Materials Science Lomonosov Moscow State UniversityMoscowRussia Institute of Mechanics Research Lomonosov Moscow State UniversityMoscowRussia Department of Chemistry Lomonosov Moscow State UniversityMoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere 10000133RomeItaly

A technique for colloidal forming of Ca2P2O7 macroporous bioceramics,based on low-pressure injection molding(LPIM)of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3Dprinting,was proposed.Chemical reaction between the solid phases of the water containing slip-Ca2P2O7 and Ca(Н2PO4)2,resulting in brushite(CaHPO4·2H2O)formation,led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out.Macroporous ceramics of Kelvin structure(70%macropores with the sizes from 2 up to 4 mm),based on a pre-defined composition with 10 wt%Ca(PO3)2 and sintered in liquid-phase regime,demonstrated a compressive strength of 1.4±0.1 MPa at a density of 22±2%.In vitro tests on bioactivity in SBF solution,as well as on resorption of the ceramics in model solution of citric acid,were carried out.

关键词： bioceramics Calcium pyrophosphate Calcium metaphosphate Colloidal forming 3D-printing Kelvin structure

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The Bisphosphonate Clodronate Modifying Hydroxyapatite bioceramics for Bone Scaffold

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 98-101页

作者：罗恩胡静 West China College of Stomatology Sichuan University Chengdu 610044 China

To investigate the efficiency of clodronate modifying HA bioceramics,and to evaluate the effect of clodronate modifying HA bioceramics on the cells in vitro,clodronate modified the porous HA bioceramics for bone scaffold by chelation .The outermost layer of the specimens was analyzd by XPS and FI-IR ,The depth profile was investigated by the argon-ion sputtering method.The cell culture test was conducted using MC3T3-E1 osteoblastic cells,The cells were inoculated and cultured on the scaffolds.Morphological observation of the cells,MTT test and ALP activity test evaluated the cell attachment ,proliferation and activity on the scaffolds.The cell culture test in cell quantity and morphology indicated active proliferation of the cells on the scaffolds.The ALP activity of the cells cultured for 3d and 7d on clodronate-HA bioceramics was slightly higher than that on HA bioceramics ,but the difference was not signifcant,This result indicated that clodronate-HA bioeramics had favorable cytocompatibility to be used as bone scaffold with potential ability to improve asteogensis.

关键词： bisphosphonate hydroxyapatite bioceramics surface modification

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Preparation,Microstructure,and Properties of ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics for 3D Printing of All-ceramic Dental Implants by Vat Photopolymerization

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第2期1卷 36-49页

作者： Lizheng Zhang Hao Liu Haihua Yao Yong Zeng Jimin Chen Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China Beijing Engineering Research Center of 3D Printing for Digital Medical Health Beijing100124China Key Laboratory of Trans-scale Laser Manufacturing Technology Ministry of EducationBeijing100124China National Key Laboratory of Human Factors Engineering Astronaut Center of ChinaBeijing100094China

Zirconia(ZrO_(2))ceramics have potential applications in the field of oral medicine owing to their desirable me-chanical properties,biocompatibility,chemical stability,and aesthetic properties.To realize clinical applications,ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics for all-ceramic dental implants were prepared using vat photopolymerization 3D printing technology,and their process optimization,microstructure,mechanics,tribology,and biological proper-ties were studied.The results indicate that when the sintering temperature and holding time are 1600℃and 3 h,respectively,the density of ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics reaches 98.79%,and its Vickers hardness,compressive strength,flexural strength,and fracture toughness also reach their maximum values.Furthermore,the in vitro sim-ulated oral environment wear tests showed that artificial saliva provides a lubricating effect on ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics and improves wear resistance.The biosafety of ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics was evaluated and ZrO_(2)(3Y)/Al_(2)O_(3)had no obvious cytotoxicity and promoted cell proliferation,growth,and adhesion.In addition,its surface has appropriate roughness and good wettability.In conclusion,ZrO_(2)(3Y)/Al_(2)O_(3)bioceramics prepared by vat photopolymerization are promising biomaterials with broad application prospects in dental restoration.

关键词： Vat photopolymerization bioceramics Mechanical properties Biocompatibility

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Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair

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Bioactive Materials 2023年第7期25卷 319-332页

作者： Yidan Wang Meng luo Ting Li Chenxi Xie Sihua Li Bo Lei Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an710054China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710054China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710054China Instrument Analysis Center Xi’an Jiaotong UniversityXi’an710054China

Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis,inflammation regulation,and skin tissue remodeling into the one system instead of single-stage boosting.In this work,a multilayer-structured bioactive glass nanopowder(BGN@PTE)is developed by coating the poly-tannic acid andε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds.In comparison to BGN and poly-tannic acid coated BGN,BGN@PTE exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation,red blood cells(RBCs)aggregation and fibrin network formation.Simultaneously,the bioactive ions from BGN facilitate the regulation of the inflammatory response while the poly-tannic acid and antibacterialε-polylysine prevent the wound infection,promoting the wound healing during the inflammatory stage.In addition,BGN@PTE can serve as a reactive oxygen species scavenger,alleviate the oxidation stress in wound injury,induce the cell migration and angiogenesis,and promote the proliferation stage of wound repair.Therefore,BGN@PTE demonstrated the significantly higher wound repair capacity than the commercial bioglass dressing Dermlin™.This multifunctional BGN@PTE is a potentially valuable dressing for full-thickness wound management and may be expected to extend to the other wounds therapy.

关键词： Bioactive materials bioceramics Bioactive glass nanoparticles Wound repair

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Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum:report of six cases

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Regenerative Biomaterials 2022年第1期9卷 156-162页

作者： Yitian Wang Xiangfeng Li Yi Luo Li Zhang Hezhong Chen Li Min Qing Chang Yong Zhou Chongqi Tu Xiangdong Zhu Xingdong Zhang Department of Orthopedics Orthopedics Research InstituteWest China HospitalSichuan UniversityChengdu 610041China Bone and Joint 3D-Printing&Biomechanical Laboratory Department of OrthopedicsWest China HospitalSichuan UniversityNo.37 GuoxuexiangChengdu 610041SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Sichuan Baiameng Bioactive Materials Limited Liability Company No.37 GuoxuexiangChengdu 610041SichuanChina

This study aimed at evaluating the possibility and effectiveness of osteoinductive bioceramics to fill the tumor cavity following the curettage of sacral giant cell tumor(GCT).Six patients(four females and two males,25–45 years old)underwent nervesparing surgery,in which the tumor was treated by denosumab,preoperative arterial embolization and extensive curettage.The remaining cavity was filled with commercial osteoinductive calcium phosphate(CaP)bioceramics,whose excellent osteoinductivity was confirmed by intramuscular implantation in beagle canine.All patients were followed by computed tomography(CT)scans postoperatively.According to the modified Neer criterion,five cases obtained Type I healing status,and one case had Type II.At the latest follow-up,no graft-related complications and local recurrence were found.The CT scan indicated a median time of healing initiation of 3months postoperatively,and the median time for relatively complete healing was 12months.The excellent bone regenerative ability of the ceramics was also confirmed by increased CT attenuation value,blurred boundary and cortical rim rebuilding.In conclusion,osteoinductive CaP bioceramics could be an ideal biomaterial to treat the large remaining cavity following extensive curettage of sacral GCT.However,further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： calcium phosphate bioceramics giant cell tumor sacrum osteoinductivity

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Evaluation of Bioactive Properties of α and β Wollastonite bioceramics Soaked in a Simulated Body Fluid

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Journal of Biomaterials and Nanobiotechnology 2018年第3期9卷 263-276页

作者： Luis A.Nunez-Rodriguez Martin A.Encinas-Romero Agustin Gomez-Alvarez Jesus L.Valenzuela-Garcia Guillermo C.Tiburcio-Munive Posgrado en Ciencias de la Ingenieria:Ingenieria Quimica Universidad de SonoraHermosilloMexico Departamento de Ingenieria Quimica y Metalurgia Universidad de SonoraHermosilloMexico

Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical properties in the materials. The products were characterized by TGA-DTA, XRD, FT-IR, SEM-EDS, TEM and XPS techniques. The results indicate the presence of two polymorphic phases of wollastonite, the β-wollastonite and α-wollastonite with a transition temperature of the β phase to α phase at approximately 1250℃. These materials were soaked in a simulated body fluid (SBF) during 1, 2 and 3 weeks, to study their solubility and bioactivity. The effect of different wollastonite phases on the solubility of Ca and Si, as well as the capacity of producing layers of “newly formed apatite” on the surfaces of these materials in SBF solution were analyzed.

关键词： bioceramics Wollastonite Simulated Body Fluid Bioactivity

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Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders

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Bioactive Materials 2022年第4期7卷 222-235页

作者： B.Le Gars Santoni L.Niggli S.Dolder O.Loeffel G.A.Sblendorio R.Heuberger RMS Foundation Bioceramics and Biocompatibility GroupBischmattstrasse 12CH-2544BettlachSwitzerland University of Bern Graduate School for Cellular and Biomedical SciencesMittelstrasse 43CH-3012BernSwitzerland University of Bern Department for BioMedical Research(DBMR)Murtenstrasse 35CH-3008BernSwitzerland RMS Foundation Materials GroupBischmattstrasse 12CH-2544BettlachSwitzerland EPFL Ecole Polytechnique Federale de LausanneConstruction Materials LaboratoryStation 12CH-1015LausanneSwitzerland

β-Tricalcium Phosphate(β-TCP),one of the most used bone graft substitutes,may contain up to 5 wt%foreign phase according to standards.Typical foreign phases includeβ-calcium pyrophosphate(β-CPP)and hydroxyapatite(HA).Currently,the effect of small amounts of impurities on β-TCP resorption is unknown.This is surprising since pyrophosphate is a very potent osteoclast inhibitor.The main aim of this study was to assess the effect of small β-CPP fractions(<1 wt%)on the in vitro osteoclastic resorption of β-TCP.A minor aim was to examine the effect of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.Twenty-six batches of β-TCP powder were produced with a Ca/P molar ratio varying between 1.440 and 1.550.Fifteen were further processed to obtain dense and polished β-TCP cylinders.Finally,six of them,with a Ca/P molar ratio varying between 1.496(1 wt% β-CPP)and 1.502(1 wt% HA),were incubated in the presence of osteoclasts.Resorption was quantified by white-light interferometry.Osteoclastic resorption was significantly inhibited by β-CPP fraction in a linear manner.The presence of 1% β-CPP reduced β-TCP resorption by 40%,which underlines the importance of controllingβ-CPP content when assessing β-TCP biological performance.

关键词： bioceramics Calcium phosphate β-Tricalcium phosphate β-Calcium pyrophosphate Hydroxyapatite Osteoclastic resorption

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