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Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

Nano Research 2024年第2期17卷 778-787页

作者： Jun Zhang Xingmei Chen Jingseng Lin Pei Zhang Iek Man Lei Yue Tao Jiajun Zhang Tian Luo Ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Research and Innovation Center SKG Health TechnologyShenzhen 518000China SAFE(Shenzhen)Medical Technology Company Limited Shenzhen 518000China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and TechnologyShenzhen 518055China

Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic *** suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous *** this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon *** address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous *** our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon *** hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

关键词： hydrogels phase separation bioadhesion robustness tendon repairing

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Accelerated Curing Speed of Ethyl a-Cyanoacrylate by Polymer with Catecholamine Groups

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Chinese Journal of Chemistry 2012年第10期30卷 2275-2280页

作者：张峰刘四委张艺许家瑞危岩 PCFM Lab School of Chemistry and Chemical EngineeringSun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Chemistry Tsinghua UniversityBeijing 100084China

Four kinds of poly（ethylene glycol）（PEG） derivatives with the similar backbone and different side groups have been synthesized successfully. When both catecholamine and double bond are tethered to polymer backbone, i.e., the PEG backbone, simultaneously, the polymer can accelerate the curing speed of ethyl a-cyanoacrylate （commer- cially available as 502） greatly under the same conditions （the curing time of such system is no more than 5 s）. Probably this is due to the autoxidation of catecholamines. Through the redox-cycling, catecholamines can produce, collect free radicals, and thus initiate the free radical polymerization. Due to the fast-curing of such material when mixed with a-cyanoacrylate, we could design and develop a new bicomponent super bioglue used in the dentistry or other bioenvironment requiring super fast settlement for further surgical operations.

关键词： catecholamines dopamines radical reactions bioadhesion

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Evaluation Preliminary of a Dry Emulsion System as a <i>Pasteurella multocida</i>Oral Carrier for Pigs

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Journal of Biosciences and Medicines 2020年第9期8卷 114-124页

作者： David Quintanar-Guerrero Edgar Aguilera Cerón María Elena Trujillo Ortega Sofia González Gallardo Alejandro Vargas Sánchez Abel Ciprián Carrasco Susana Mendoza Elvira Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Mexico City México Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Mexico City México

Background: This work evaluated the capacity of a dry emulsion as a carrier of viable microorganisms with potential use as prophylaxis of infectious diseases. Methods: The aqueous phase containing P. multocida not viable in PBS was emulsified in mineral oil to obtain a w/o emulsion. The microorganisms remained stable and only in two cases (n = 6) did the bacterial concentration decrease. Scanning Electron Microscopy (SEM) revealed a structure of a system with the organized association of particles with cubic symmetry. Using two ex vivo bioadhesion systems, it was demonstrated that the disperse-adsorbed system is capable of adhering to the intestinal mucosa and remains adhered for long periods of time. Results: The no viability of the bacteria in the dry emulsion and the possibility of controlled release were confirmed. In vivo trial was conducted in pigs. It was possible to locate the emulsion and the bacteria attached to the gut of the living animal. An ELISA kit was used to monitor the mean antibody titer of treated pigs over a 2-week period, and a classic primary response curve occurred when the titer was plotted against time. Conclusion: We propose the disperse-adsorbed system as an alternative to commonly used vehicles for immunogens in the oral vaccines.

关键词： Dry Emulsion Oral Carrier Pasteurella multocida Pigs bioadhesion

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Isoreactive Manipulation of Bioadhesive Polymers Impacts Tissue-Specific Interactions

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Journal of Biomedical Science and Engineering 2017年第5期10卷 287-303页

作者： Jahid Ferdous Eva Romito Heather Doviak Alexandra Moreira Mark J. Uline Francis G. Spinale Tarek Shazly College of Engineering and Computing University of South Carolina Columbia SC USA Cardiovascular Translational Research Center School of Medicine University of South Carolina Columbia SC USA Department of Cell Biology and Anatomy School of Medicine University of South Carolina Columbia SC USA WJB Dorn Veteran Affairs Medical Center Columbia SC USA

Bioadhesive polymers can serve as surgical sealants with a wide range of potential clinical applications, including augmentation of wound closure and acute induction of hemostasis. Key determinants of sealant efficacy include the strength and duration of tissue-material adhesion, as well as material biocompatibility. Canonical bioadhesive materials, however, are limited by a tradeoff among performance criteria that is largely governed by the efficiency of tissue-material interactions. In general, increasingly bioreactive materials are endowed with greater bioadhesive potential and protracted residence time, but incite more tissue damage and localized inflammation. One emergent strategy to improve sealant clinical performance is application-specific material design, with the goal of leveraging both local soft tissue surface chemistry and environmental factors to promote adhesive tissue-material interactions. We hypothesize that copolymer systems with equivalent bioreactive group densities (isoreactive) but different amounts/oxidation states of constituent polymers will exhibit differential interactions across soft tissue types. We synthesized an isoreactive family of aldehyde-mediated co-polymers, and subjected these materials to physical (gelation time), mechanical (bulk modulus and adhesion strength), and biological (in-vitro cytotoxicity and in-vivo biocompatibility) assays indicative of sealant performance. Results show that while bioadhesion to a range of soft tissue surfaces (porcine aortic adventitia, renal artery adventitia, renal cortex, and pericardium) varies with isoreactive manipulation, general indicators of material biocompatibility remain constant. Together these findings suggest that isore-active tuning of polymeric systems is a promising strategy to circumvent current challenges in surgical sealant applications.

关键词： bioadhesion Dextran Aldehyde Soft Tissue Polymer Surgical Sealant

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Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release

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Acta Pharmaceutica Sinica B 2012年第5期2卷 509-517页

作者： Sharad S.Darandale Pradeep R.Vavia Department of Pharmaceutical Sciences and Technology Institute of Chemical TechnologyMumbai 400019India

The aim of the present study was to develop and characterize a gastroretentive dosage form suitable for controlled drug *** consists of a drug loaded polymeric film made up of a bilayer of immediate(IR)and controlled release(CR)layers folded into a hard gelatin *** roretention results from unfolding and swelling of the film and its bioadhesion to the ***,a drug with a narrow absorption window,was selected as the model *** of hydroxypropyl β-cyclodextrin in both layers and Carbopol■ 971P NF in the CR layer of the bilayer film resulted in optimum drug release,bioadhesion and mechanical *** film with zig-zag folding in the capsule was shown to unfold and swell under acidic conditions and provide IR of drugover 1 hand CR for up to 12 h in acidic medium.X-ray diffraction,differential scanning calorimetry and scanning electron microscopy revealed uniform dispersion of furosemide in the polymeric *** results indicate the dosage form is gastroretentive and can provide controlled release of drugs with narrow therapeutic wind ows.

关键词： Gastroretentive dosage form Controlled release Furosemide bioadhesion Bilayer film Hydroxypropylβ-cyclodextrin Carbopol

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生物粉体在中药现代化中的应用概述(英文)

生物粉体在中药现代化中的应用概述(英文)

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生物颗粒与粉体制备、应用技术研讨会

作者：张文君沈阳药科大学

To improve the bioavailability of hawthorn leaves flavonoids（HLF）, bioadhesive powders（BP） were prepared by an emulsion-solvent evaporation technique. Bioadhesive polymers such as sodium alginate（SA）,carboxyl chitosan（CPCTS） and carbopol 974p（CP） were used in the bioadhesive powders *** formulations of HLF bioadhesive powders were respectively given to six healthy beagle *** from statistical analysis showed that there were significant differences between the HLF-BP and the commercially available HLF pills in pharmacokinetic parameters（AUC0-∞,Cmax and Tmax）.The rate and extent of absorption of HLF-BP was found to be significantly faster and larger than HLF pills,as shown by a higher Cmax, a shorter Tmax and a larger *** to HLF *** bioavailability of HLF in beagle dogs was improved by using bioadhesion.

关键词： powders Hawthorn leaves flavonoids bioadhesion bioavailability

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