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An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

bioactive materials 2022年第1期7卷 491-503页

作者： Hai Ming Wong Yu Yuan Zhang Quan Li Li Paediatric Dentistry and Orthodontics Faculty of DentistryThe University of Hong Kong34 Hospital RoadHong Kong Collage and Hospital of Stomatology Anhui Medical UniversityNo.69Meishan RoadHeifeiChina

Conventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties.Moreover,restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting,acidogenic bacteria invasion of the defective cite.In order to resolve the limitations of the conventional dental materials,the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property.The evaporation-based,bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components.The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film.Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components,mechanical properties and crystallographic structure.Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility.In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism,this study brings new prospects for the synthesis of enamel-inspired materials.

关键词： Biomimetic mineralization Enamel-inspired material bioactive material Graphene oxide Enamel-like structure

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Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury

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Neural Regeneration Research 2022年第9期17卷 2064-2071页

作者： Wanlin Xu Yifan Wu Hao Lu Yun Zhu Jinhai Ye Wenjun Yang Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Jiangsu Key Laboratory of Oral Diseases Department of Oral and Maxillofacial SurgeryThe Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration arriving at the injury site results in unsatisfactory outcomes.Therefore,there is an urgent need for a treatment method that can increase the effective drug concentration in the injured area.In this study,we first fabricated a gelatin modified by methacrylic anhydride hydrogel and loaded it with vascular endothelial growth factor that allowed the controlled release of the neurotrophic factor.This modified gelatin exhibited good physical and chemical properties,biocompatibility and supported the adhesion and proliferation of RSC96 cells and human umbilical vein endothelial cells.When injected into the epineurium of crushed nerves,the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration,functional recovery and vascularization.The results showed that the modified gelatin gave sustained delivery of vascular endothelial growth factors and accelerated the repair of crushed peripheral nerves.

关键词： bioactive material controlled release crush injury hydrogel muscle function nerve regeneration peripheral nerve sciatic function index vascular endothelial growth factor vascularization

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3D bioactive cell-free-scaffolds for in-vitro/in-vivo capture and directed osteoinduction of stem cells for bone tissue regeneration

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bioactive materials 2021年第11期6卷 4083-4095页

作者： Mamatali Rahman Xue-Liang Peng Xiao-Hong Zhao Hai-Lun Gong Xiao-Dan Sun Qiong Wu Dai-Xu Wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an710069China MOE Key Laboratory of Bioinformatics Center for Synthetic and System BiologyTsinghua UniversityBeijing100084China School of Life Sciences Tsinghua UniversityBeijing100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Key Laboratory of Advanced materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Hydrophilic bone morphogenetic protein 2(BMP2)is easily degraded and difficult to load onto hydrophobic carrier materials,which limits the application of polyester materials in bone tissue engineering.Based on soybean-lecithin as an adjuvant biosurfactant,we designed a novel cell-free-scaffold of polymer of poly(ε-caprolactone)and poly(lactide-co-glycolide)-co-polyetherimide with abundant entrapped and continuously released BMP2 for in vivo stem cell-capture and in situ osteogenic induction,avoiding the use of exogenous cells.The optimized bioactive osteo-polyester scaffold(BOPSC),i.e.SBMP-10SC,had a high BMP2 entrapment efficiency of 95.35%.Due to its higher porosity of 83.42%,higher water uptake ratio of 850%,and sustained BMP2 release with polymer degradation,BOPSCs were demonstrated to support excellent in vitro capture,proliferation,migration and osteogenic differentiation of mouse adipose derived mesenchymal stem cells(mADSCs),and performed much better than traditional BMP-10SCs with unmodified BMP2 and single polyester scaffolds(10SCs).Furthermore,in vivo capture and migration of stem cells and differentiation into osteoblasts was observed in mice implanted with BOPSCs without exogenous cells,which enabled allogeneic bone formation with a high bone mineral density and ratios of new bone volume to existing tissue volume after 6 months.The BOPSC is an advanced 3D cell-free platform with sustained BMP2 supply for in situ stem cell capture and osteoinduction in bone tissue engineering with potential for clinical translation.

关键词： Soybean lecithin bioactive material Cell-free scaffold BMP2 Cell-capture Ossification

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Chitosan based bioactive materials in tissue engineering applications-A review

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bioactive materials 2020年第1期5卷 164-183页

作者： Md.Minhajul Islam Md.Shahruzzaman Shanta Biswas Md.Nurus Sakib Taslim Ur Rashid Department of Applied Chemistry and Chemical Engineering Faculty of Engineering and TechnologyUniversity of DhakaDhaka1000Bangladesh Fiber and Polymer Science North Carolina State UniversityCampus Box 7616RaleighNC27695United States

In recent years,there have been increasingly rapid advances of using bioactive materials in tissue engineering applications.bioactive materials constitute many different structures based upon ceramic,metallic or polymeric materials,and can elicit specific tissue responses.However,most of them are relatively brittle,stiff,and difficult to form into complex shapes.Hence,there has been a growing demand for preparing materials with tailored physical,biological,and mechanical properties,as well as predictable degradation behavior.Chitosan-based materials have been shown to be ideal bioactive materials due to their outstanding properties such as formability into different structures,and fabricability with a wide range of bioactive materials,in addition to their biocompatibility and biodegradability.This review highlights scientific findings concerning the use of innovative chitosan-based bioactive materials in the fields of tissue engineering,with an outlook into their future applications.It also covers latest developments in terms of constituents,fabrication technologies,structural,and bioactive properties of these materials that may represent an effective solution for tissue engineering materials,making them a realistic clinical alternative in the near future.

关键词： Chitosan bioactive material Scaffold Tissue engineering

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Advanced application of collagen-based biomaterials in tissue repair and restoration

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Journal of Leather Science and Engineering 2022年第1期4卷 409-427页

作者： Jiayi Zhu Zhulian Li Yaping Zou Gonggong Lu Alfredo Ronca Ugo D’Amora Jie Liang Yujiang Fan Xingdong Zhang Yong Sun National Engineering Research Center for Biomaterials Sichuan University29#Wangjiang RoadChengdu 610064People’s Republic of China Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly College of Biomedical Engineering Sichuan University29#Wangjiang RoadChengdu 610064People’s Republic of China Department of Neurosurgery West China HospitalSichuan University37#Guoxue LaneChengdu 610041SichuanPeople’s Republic of China Sichuan Testing Center for Biomaterials and Medical Devices Sichuan University29 Wangjiang RoadChengdu 610064People’s Republic of China.

In tissue engineering,bioactive materials play an important role,providing structural support,cell regulation and establishing a suitable microenvironment to promote tissue regeneration.As the main component of extracellular matrix,collagen is an important natural bioactive material and it has been widely used in scientific research and clinical applications.Collagen is available from a wide range of animal origin,it can be produced by synthesis or through recombinant protein production systems.The use of pure collagen has inherent disadvantages in terms of physico-chemical properties.For this reason,a processed collagen in different ways can better match the specific requirements as biomaterial for tissue repair.Here,collagen may be used in bone/cartilage regeneration,skin regeneration,cardiovascular repair and other fields,by following different processing methods,including cross-linked collagen,complex,structured collagen,mineralized collagen,carrier and other forms,promoting the development of tissue engineering.This review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration fields.Furthermore,the application prospect of bioactive materials based on collagen was outlooked,aiming at inspiring more new progress and advancements in tissue engineering research.

关键词： Collagen bioactive material Tissue engineering Regeneration Repair

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Constructing a highly bioactive tendon-regenerative scaffold by surface modification of tissue-specific stem cell-derived extracellular matrix

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Regenerative Biomaterials 2022年第1期9卷 81-92页

作者： Liang-Ju Ning Jing Cui Shu-Kun He Ruo-Nan Hu Xuan Yao Yi Zhang Wei Ding Yan-Jing Zhang Jing-Cong Luo Ting-Wu Qin Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041P.R.China Department of Orthopedic Surgery Orthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Core Facility West China HospitalSichuan UniversityChengduSichuan 610041P.R.China

Developing highly bioactive scaffold materials to promote stem cell migration,proliferation and tissue-specific differentiation is a crucial requirement in current tissue engineering and regenerative medicine.Our previous work has demonstrated that the decellularized tendon slices(DTSs)are able to promote stem cell proliferation and tenogenic differentiation in vitro and show certain pro-regenerative capacity for rotator cuff tendon regeneration in vivo.In this study,we present a strategy to further improve the bioactivity of the DTSs for constructing a novel highly bioactive tendon-regenerative scaffold by surface modification of tendon-specific stem cell-derived extracellular matrix(tECM),which is expected to greatly enhance the capacity of scaffold material in regulating stem cell behavior,including migration,proliferation and tenogenic differentiation.We prove that the modification of tECM could change the highly aligned surface topographical cues of the DTSs,retain the surface stiffness of the DTSs and significantly increase the content of multiple ECM components in the tECM-DTSs.As a result,the tECM-DTSs dramatically enhance the migration,proliferation as well as tenogenic differentiation of rat bone marrow-derived stem cells compared with the DTSs.Collectively,this strategy would provide a new way for constructing ECMbased biomaterials with enhanced bioactivity for in situ tendon regeneration applications.

关键词： tendon-regenerative scaffold extracellular matrix bioactive material tissue-specific stem cell

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Development of bioactive materials for glioblastoma therapy

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bioactive materials 2016年第1期1卷 29-38页

作者： Jun Yang Yan Li Tianlu Zhang Xin Zhang National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

Glioblastoma is the most common and deadly human brain cancers.Unique barriers hinder the drug delivering pathway due to the individual position of glioblastoma,including blood-brain barrier and blood-brain tumor barrier.Numerous bioactive materials have been exploited and applied as the transvascular delivery carriers of therapeutic drugs.They promote site-specific accumulation and long term release of the encapsulated drugs at the tumor sites and reduce side effects with systemic delivery.And the delivery systems exhibit a certain extent of anti-glioblastoma effect and extend the median survival time.However,few of them step into the clinical trials.In this review,we will investigate the recent studies of bioactive materials for glioblastoma chemotherapy,including the inorganic materials,lipids and polymers.These bioactive materials construct diverse delivery vehicles to trigger tumor sites in brain intravenously.Herein,we exploit their functionality in drug delivery and discuss the deficiency for the featured tumors,to provide guidance for establishing optimized therapeutic drug formulation for anti-glioblastoma therapy and pave the way for clinical application.

关键词： Glioblastoma bioactive material Blood-brain barrier Blood-brain tumor barrier Chemotherapy

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