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The effects of captopril on osteoporosis in ovariactomized rats and on differentiation of cultured primary osteoblasts

The effects of captopril on osteoporosis in ovariactomized r...

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中国药理学会第十次全国学术会议

作者： Yu-Yu Liu,Liao Cui~*,Tie Wu (Dept of Pharmacology,Guangdong Medical College,Zhanjiang 524023,China)

Antihypertensive drugs may have an effect on osteoporosis(OP),bone mineral density(BMD),and bone *** present study was designed to investigate the preventive effects of captopril,an angiotensin-converting enzyme inhibitor(ACEI),on osteoporosis in aged ovariectomized(OVX) rats and its impact on the differentiation of cultured primiary *** 10-month-old Wistar rats were ovariectomized(OVX) and,2 months later,were treated with captopril or *** static and dynamic parameters in trabecular bone of the forth lumbar vertebrae(LV4) were examined with histomorphometrical analysis,the fifth lumbar vertebrae(LV5) were used to perform the compression *** osteoblasts were isolated from the calvaria of new born rats and treated with various concentrations of captopril for various *** characterization of osteoblastic origin was carried out with the staining of alkaline phosphatese(ALP).The effects of captopril on the content of ALP and the mRNA expression of collagenⅠwere determined with examination of para-nitro-pheneye phosphate and RT-PCR..Under the circumstances of estrogen deficiency-induced osteopenia,Captopril increased trabecular area(%***) up to 33%,improved the biomechanical status,increased the break stress and elastic modulus in OVX *** a lower dose,the agent increased the break load,break stress and elastic ***,Captopril promoted the expression of ALP and stimulated the anabolic metabolism of collagenⅠin cultured rat *** summary, Captopril,as one of the most widely used ACEI,has the potential of improving the biomechanical status in osteoporosis and promoting the bone formation in osteoblasts.

关键词： captopril osteoporosis ovariectomized rat osteoblast histocytochemistry morphology bio-mechanical properties

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