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Construction of bio-functional Mg/HA composite layered coating for orthopedic application

Science China(Technological Sciences) 2021年第11期64卷 2541-2550页

作者： WAN Peng YAN XuDong LI Mei ZHAO MingChun ZHANG Yu YANG Ke School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Central South UniversityChangsha 410083China Research Center of Medical Sciences Guangdong Provincial People s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.

关键词： magnesium HA composite layered coating titanium orthopedic bio-function

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