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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model

Traditional Medicine Research 2024年第2期9卷 8-17页

作者： Ao Qier Naren Mandula Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang Pharmaceutical Laboratory Inner Mongolia International Mongolian HospitalHohhot 010065China College of Mongolian Medicine Inner Mongolia Medical UniversityHohhot 010110China Medical Innovation Center for Nationalities Inner Mongolia Medical UniversityHohhot 010110China Institute of Mongolian Medicinal Chemistry School of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot 010021China School of Life Sciences Inner Mongolia UniversityHohhot 010021China

Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass ***,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine ***:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 *** the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine ***-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior *** sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal ***:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass *** discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology ***“compound-target-disease”network contained 163 intersection targets with the migraine *** Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,*** Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,*** predictions were further demonstrated via in vivo animal model *** RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreat

关键词： Horcha-6 bio-active components rat migraine model inflammation hormone metabolism neurotransmitter

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