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Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties

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Cellular & Molecular Immunology 2021年第9期18卷 2224-2235页

作者： Zongshan Shen Shuhong Kuang Min Zhang Xin Huang Jiayao Chen Meiliang Guan Wei Qin Hockin H.K.Xu Zhengmei Lin Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhouGuangdongChina Department of Andrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina The Key Laboratory for Stem Cells and Tissue Engineering Center for Stem Cell Biology and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhouGuangdongChina Department of Advanced Oral Sciences&Therapeutics University of Maryland School of DentistryBaltimoreMDUSA Center for Stem Cell Biology and Regenerative Medicine University of Maryland School of MedicineBaltimoreMDUSA University of Maryland Marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMDUSA

Diabetes-associated periodontitis(DP)aggravates diabetic complications and increases mortality from *** is caused by diabetes-enhanced host immune-inflammatory responses to bacterial *** this study,we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to ***,inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal ***,bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic *** finding provides a basis for the development of an effective therapeutic approach for treating DP.

关键词： Diabetes-associated periodontitis bindarit proinflammatory monocytes macrophages

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Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 201-207页

作者： Zhou, Guo-Xiong Zhu, Xue-Juan Ding, Xiao-Ling Zhang, Hong Chen, Jian-Ping Qiang, Hui Zhang, Hai-Feng Wei, Qun Nantong Univ Affiliated Hosp Dept Gastroenterol Nantong 226001 Peoples R China

BACKGROUND: Chemokines and their receptors play key roles in the pathogenesis of acute pancreatitis. This study aimed to establish a rat model of severe acute pancreatitis (SAP) for investigating monocyte chemotactic protein-1 (MCP-1) expression in the pathogenesis of the disease. We assessed the effects of the inhibitor of MCP-1, bindarit, on SAP and explored the mechanisms underlying SAP. METHODS: Seventy-two Sprague-Dawley rats were randomly divided into a saline control group (group S), an SAP group (group P), and a bindarit group (group T). The SAP model was induced by retrograde infusion of 4% sodium taurocholate into the bilio-pancreatic duct. Based on the SAP model, bindarit was injected intraperitoneally in group T, and 0.5% methyl cellulose was injected intraperitoneally in groups S and P. In group S, saline was retrogradely infused into the bilpancreatic duct. Serum amylase levels and the histological changes in the pancreas were assessed at different time-points in each group. Expression of MCP-1 in serum was measured by enzyme-linked immunoadsorbent assay (ELISA). MCP-1 protein and mRNA expression levels were detected by immunohistochemistry, Western blotting, and semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Serum amylase levels in groups P and T were higher than those in group S. Serum amylase levels were significantly lower in group T than in group P at 6 and 12 hours after operation. The levels of MCP-1 in serum at 6 and 12 hours after operation in group P were significantly higher than in group S, and significantly lower in group T than in group P at 6 and 12 hours after operation. The pathological damage in the pancreas was milder in group T than in group P. MCP-1 protein and mRNA expression levels in the pancreas were higher in groups P and T than in group S. These expression levels were positively correlated with the pathological damage of pancreatic tissues. The activity of MCP-1 in group T was significant

关键词： severe acute pancreatitis monocyte chemotactic protein-1 bindarit pathogenesis

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