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Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application

Regenerative Biomaterials 2020年第1期7卷 119-127页

作者： Yuqing Zhang Danni Sun Jun Cheng James Kit Hon Tsoi Jiang Chen School and Hospital of Stomatology Fujian Medical UniversityFuzhou 350002FujianChina Stomatological Key Laboratory of Fujian College and University Fujian Medical UniversityFuzhou 350002FujianChina Faculty of Dentistry Dental Materials ScienceDivision of Applied Oral Sciences and Community Dental CareThe University of Hong KongHong Kong SARChina Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016ShaanxiChina

binary titanium–niobium(Ti–Nb)alloys have recently been attracted due to low Young’s moduli and non-toxic *** study explores the influence of low Nb content(0–25 wt%)on the comprehensive parameters of tensile stress–strain relationships(ultimate strength(rUTS),yield strength(r0.2)and elastic modulus(E)),surfaces properties(Vickers microhardness,surface roughness(Ra),water contact angle(WCA),X-ray diffraction(XRD)and scanning electron microscopy(SEM)),corrosion resistance(in artificial saliva and lactic acid)and biological properties(cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts)of Ti–xNb alloys(x紏5,10,15,20 and 25 wt%),with using commercially pure grade 2 titanium(cp-Ti)as *** results shown that all the Ti–xNb alloys comprised atb Ti alloy phases,such that the b phase increased correspondingly with the increased amount of Nb in the alloy,as well as the reduction of E(69–87 GPa).Except Ti–5Nb,all other Ti–xNb alloys showed a significantly higher hardness,increased rUTS and r0.2,and decreased WCA compared with *** corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid *** cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour,but the proliferation rate of the Ti–5Nb alloy was lower than other *** overall,binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance,while Ti–5Nb should be used with caution.

关键词： biomaterial titanium-niobium binary titanium alloys low Young’s modulus biocompatibility

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