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bile acids in serum and bile of patients with cholesterol gallstone

World Journal of Gastroenterology 1998年第1期4卷 87-89页

作者： HAN Tian-Quan ZHANG Sheng-Dao TANG Wen-Hao JIANG Zhao-Yan Department of Surgery Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China Department of Surgery Affiliated Hospital Nanjing Railway Medical College Nanjing 210009 China Bengbu Medical College China Shanghai Second Medical University China Department of Surgery Ruijin Hospital Shanghai Second Medical University Shanghai 200025 197 Ruijin Erlu China

IM To analyze serum bile acids and biliary lipids of patients with cholesterol gallstone(CS) and explore the relationship between deoxycholic acid (DCA) and CS disease.METHODS analysis of bile acids in serum was done with gaschromatography in two groups: CS group (n=151) and control group (n=256). Serum bile acids and biliary lipids were also studied in 90 matched samples..RESULTS The serum DCA was 0955μmol/L±0078μmol/L in CS group, which was more than that of control group (0696μmol/L±0047μmol/L), Pacids (CDCA) was 176±030 in CS group, about two times that in control group (092±014). The mole percent of DCA in bile was positively related to cholesterol saturation index (CSI) (Pbile negatively to CSI (P=001). There was correlation between the mole percent of DCA, CDCA and cholic acid in bile and in serum.CONCLUSION It is suggested that DCA is lithogenic and the increased amount of DCA or the ratio of DCA/CDCA in serum may be one of the features of cholesterol gallstone patients.

关键词： cholesterol gallstone bile acids/analysis deoxycholic acids/analysis chromatography,gas

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