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Effect of behavior training on learning and memory of young rats with fetal growth restriction

Journal of Medical Colleges of PLA(China) 2008年第5期23卷 283-288页

作者： Li Xuelan Gou Wenli Huang Pu Li Chunfang Sun Yunping Department of Obstetrics and Gyneeology First Affiliated Hospital Medical College of Xi ＇an Jiaotong University Xi＇an 710061 China

Objective: To investigate the effect of behavior training on the learning and memory of young rats with fetal growth restriction (FGR). Methods: The model of FGR was established by passive smoking method to pregnant rats. The new-born rats were divided into FGR group and normal group, and then randomly subdivided into trained and untrained group respectively. Morris water maze behavior training was performed on postnatal months 2 and 4, then learning and memory abilities of young rats were measured by dark-avoidance testing and step-down testing. Results: In the dark-avoidance and step-down testing, the young rats’ performance of FGR group was worse than that of control group, and the trained group was better than the untrained group significantly. Conclusion: FGR young rats have descended learning and memory abilities. behavior training could improve the young rats’ learning and memory abilities, especially for the FGR young rats.

关键词： Fetal growth restriction Learning and memory behavior training

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Effect of behavior training on learning,memory and the expression of NR2B,GluR1 in hippocampus of rats offspring with fetal growth restriction

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Journal of Nanjing Medical University 2008年第5期22卷 290-294页

作者： Chunfang Li Wenli Gou Yunping Sun Huang Pu Department of Obstetrics and Gynecology the First Affiliated Hospital of Xi' an Jiaotong University Xi' an 710061 Shaanxi Province China

Objective： To study effects of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rat＇ s offspring with fetal growth restriction（FGR）. Methods： The rat model of FGR was established by passive smoking method. The rats offspring were divided into the FGR group and the control group, then randomly divided into the trained and untrained group, respectively. Morris water maze test was proceeded on postnatal month（PM2/4） as a behavior training method, then the learning-memory of rats was detected through dark-avoidance and step-down tests. The expressions of NR2B and GluR1 subunits in hippocampal CA1 and CA3 areas were detected by immunohistochemical method. Results： In the dark-avoidance and step-down tests, the performance record of rats with FGR was worse than that of control rats, and the behavior-trained rats was better than the untrained rats, when the FGR model and training factors were analyzed singly. The model factor and training factor had significant interaction（P 〈 0.05）. The expressions of NR2B and GluR1 subunits in hippocampal CA1 and CA3 areas of rats with FGR reduced. In contrast, the expressions of GluR1 and NR2B subunits in CA1 area of behavior-trained rats increased, when the FGR model and training factors were analyzed singly. Conclusion： These findings suggested that the effect of behavior training on the expressions of NR2B and GluR1 subunits in CA1 area should be the mechanistic basis for the training-induced improvement in learning-memory abilities.

关键词： FGR learning and memory behavior training NR2B GluR1

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