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World Journal of Emergency Medicine 2024年第5期15卷 413-415页

作者： Juhao Zeng Yin Wen Hongguang Ding Dongxin Li Hongke Zeng Department of Critical Care Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Emergency Department Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China

Strongyloidiasis stercoralis can cause disease when larvae invade the human body through the skin or mucosa and can also infect a host when the host ingests its eggs.[1]Strongyloidiasis lacks characteristic manifestations,and its clinical symptoms are related to the immune response of the host and the degree of *** cient patients with underlying disease or who are receiving long-term corticosteroid treatment are more prone to developing severe disease.[2]The present study reports a case of Strongyloides stercoralis-induced sepsis and acute respiratory distress syndrome(ARDS)in a patient with Guillain-barrésyndrome.

关键词： distress barr sepsis

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In situ detection of Epsteinbarr virus in gastric carcinoma tissuein China highrisk area

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World Journal of Gastroenterology 1999年第6期5卷 531-532页

作者： WAN Rong, GAO Mei Qin, GAO Ling Yun, CHEN Bi Feng and CAI Qian Kun 福建医科大学福建福州 350004 福建医科大学福建福州

INTRODUCTIONEpstein-barr virus (EBV), a gammaherpesvirus, has been strongly associated with African Burkitt's lymphoma and nasopharyngeal carcinoma. Recently it has been identified in lymphoepithelioma-like carcinoma of thymus, tonsil, lung and in some gastric carcinoma[1-4]. The development of very sensitive methods for detection of EBV infection in archival pathologic tumor sections has allowed us to study the association of EBV with gastric adenocarcinomas by using in situ hybridization with EBER-1 oligoprobes and immunohistochemistry with anti-LMP1 antibodies.

关键词： stomach neoplasms Epstein barr virus in situ hybridization LMP 1 protein

Epstein barr virus-positive mucocutaneous ulcer of thecolon associated Hodgkin lymphoma in Crohn＇s disease

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World Journal of Gastroenterology 2015年第19期21卷 6072-6076页

作者： Neil R Moran Bradley Webster Kenneth M Lee Judith Trotman YiuLam Kwan John Napoli Rupert W Leong Neil R Moran Rupert gW Leong Gastroenterology and Liver Services Concord Repatriation General Hospital Sydney NSW 2137 Australia.

Epstein barr virus （EBV） positive mucocutaneous ulcers（EBVMCU） form part of a spectrum of EBV-associatedlymphoproliferative disease. They have been reportedin the setting of immunosenescence and iatrogenicimmunosuppression, affecting the oropharyngeal mucosa,skin and gastrointestinal tract （GIT）. Case reports andseries to date suggest a benign natural history respondingto conservative management, particularly in the GIT. Wereport an unusual case of EBVMCU in the colon, arisingin the setting of immunosuppression in the treatment ofCrohn＇s disease, with progression to Hodgkin lymphoma18 mo after cessation of infliximab. The patient presentedwith multiple areas of segmental colonic ulceration,histologically showing a polymorphous infiltrate withEBV positive Reed-Sternberg-like cells. A diagnosisof EBVMCU was made. The ulcers failed to regressupon cessation of infliximab and methotrexate for 18mo. Following commencement of prednisolone for herCrohn＇s disease, the patient developed widespreadHodgkin lymphoma which ultimately presented as alife-threatening lower GIT bleed requiring emergencycolectomy. This is the first report of progression ofEBVMCU to Hodgkin lymphoma, in the setting of ongoingiatrogenic immunosuppression and inflammatory boweldisease.

关键词： Epstein barr virus Mucocutaneous ulcer Hodgkin lymphoma Inflammatory bowel disease Crohn's disease

Association between Guillain-barré syndrome and hepatitis E infection: A data-driven ecological study in Hong Kong

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Asian Pacific Journal of Tropical Medicine 2021年第1期14卷 47-48页

作者： Xue Liang Shi Zhao Department of Hematology The 989th Hospital of the Joint Logistics Support Force of Chinese PLALuoyang471031China JC School of Public Health and Primary Care Chinese University of Hong KongHong Kong SARChina Shenzhen Research Institute of Chinese University of Hong Kong ShenzhenChina

Guillain-barrésyndrome(GBS)is an uncommon neurological disorder that may cause damage to the peripheral nerves[1].The triggering of GBS is commonly caused by Campylobacter jejuni and other bacterial and viral *** infections as the triggering factors including hepatitis A,B,C,E viruses are being increasingly recognized[2,3].Among all hepatitis,hepatitis E virus(HEV)is more likely to be under-diagnosed,most being subclinical *** developed countries,extra-hepatic manifestations as well as clinical disorders may occur[2].

关键词： barr hepatitis Guillain

Concomitant transverse myelitis and Guillain-barré syndrome following varicella-zoster virus infection

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Chinese Medical Journal 2023年第10期136卷 1256-1257页

作者： Danmei Lan Lingyu Liu Department of Neurorehabilitation Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghai 201619China

To the Editor:Currently known syndromes of acute post-infectious or inflammatory demyelination include acute disseminated encephalomyelitis,encephalitis,transverse myelitis(TM),and Guillain–barrésyndrome(GBS).Demyelination is frequently limited to the central or peripheral nervous *** coexistence of myelitis and demyelinating peripheral neuropathy has only been reported in a few children[1,2]and young adults.[3]Also,concomitant TM and GBS in elderly immunocompetent patients has been rarely described.

关键词： barr zoster encephalitis

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Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein barr virus encoded latent membrane protein 1

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Science China(Life Sciences) 2005年第1期48卷 70-80页

作者： Leo M.Lee Laboratory of Molecular Technology SAIC-Frederick

Epstein-barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 HNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma.

关键词： Epstein barr virus, latent membrane protein 1, Jun B, c-Jun, heterodimer, DNA binding, JNK, JIP.

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A Case Report of Pediatric Epstein barr Virus (EBV) Related Cholestasis from Al-Adan Hospital, Kuwait

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Open Journal of Pediatrics 2015年第1期5卷 23-26页

作者： Fawaz Al-Refaee Sarah Al-Enezi Enamul Hoque Assad Albadrawi Department of Pediatrics Al-Adan Hospital Ministry of Health Kuwait Kuwait

Infectious mononucleosis is an acute illness due to Epstein barr virus infection, which occurs commonly in young adults. Liver involvement in acute EBV infection occurs in up to 95% of patients between the 6th and 15th day of illness and is usually mild [1]. Here we report on a 7-year-old girl treated by Gastroenterology, Hepatology, and Nutrition Unit of Al-Adan Hospital pediatric Department, presented with prolonged fever, lymphadenopathy, generalized edema, hyperbilurubi- nemia and elevated liver enzymes secondary to EBV infection. This case represents a rare presentation of common viral infection in pediatric population.

关键词： Epstein barr Virus (EBV)

Kikuchi-Fujimoto Disease Associated to the Epstein-barr Virus. A Type of Rare Necrotizing Lymphadenitis and Its Differential Diagnosis

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Open Journal of Pathology 2013年第4期3卷 186-192页

作者： Mónica Belinda Romero Guadarrama Oscar Daniel Guzmán-Aguilar Adriana Carolina López-Ugalde José Samuel Almeida Navarro Humberto Cruz-Ortíz Unidad de Patología Hospital General de México “Dr. Eduardo Liceaga” México D.F. México

Introduction: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a specific and self-limited disease;its etiology is unknown. Some causal microorganisms have been proposed. The objective of the present article is to emphasize the clinicopathological characteristics of this disease that has been associated to the Epstein-barr virus and to compare the histological changes with other types of necrotizing lymphadenopathies. Material and Methods: We studied 32 patients of the Surgical Pathology Service with necrotizing lymphadenitis, diagnosed in the years from 2004 to 2012 to found more cases of this rare disease in our Institution. Patients were 18 women and 14 men with an average age of 37 years. Results: The lymph nodes were cervical and axillary ones, some were associated to autoimmune diseases and no cause was identified in others. One of the cases, was diagnosed as KFD, presented morphological changes characteristic of this disease, such as subcapsular lymphoid follicles, zones with cell debris, epithelioid macrophages, clear-cytoplasm histiocytes, and immunoblast-reactive lymphocytes. Immunohistochemical markers were determined, such as CD20, CD2, CD4, CD8, CD68, lysozyme, CD56, granzyme B and EBER, which demonstrated the presence of B, T lymphocytes, histiocytes and cells positive to EBER. Histological changes in KFD occurred in three stages: proliferative stage, necrotizing, and xanthomatous. It is important to identify the histological stages of the disease because a differential diagnosis must be performed in regard to lymphadenopathies with necrosis and diverse types of lymphomas. Conclusion: We present a case of necrotizing lymphadenitis (KFD) associated to the Epstein-barr virus and in some cases it is not possible to render a specific diagnosis based on morphologic findings, alone, and a diagnosis of necrotizing lymphadenitis may be used.

关键词： Kikuchi-Fujimoto Disease Epstein barr Virus

barr小体的石碳酸复红(Carbolfuchsin)染色法及预测胎儿性别初步观察

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蚌埠医学院学报 1980年第4期 57-61页

作者：温昌祥蚌埠医学院生物学教研组蚌埠医学院附院妇产科

报导barr小体的石碳酸复红(Carbolfuchsin)染色法.经作者初步预测胎儿性别的结果,证明是一种较好的染色方法.此法比较简便、快速,易于观察.barr小体呈紫红色,质地均匀,轮廓清楚,醒目清晰,比较适合于基层医疗卫生单位和计划生育部门开展... 详细信息

报导barr小体的石碳酸复红(Carbolfuchsin)染色法.经作者初步预测胎儿性别的结果,证明是一种较好的染色方法.此法比较简便、快速,易于观察.barr小体呈紫红色,质地均匀,轮廓清楚,醒目清晰,比较适合于基层医疗卫生单位和计划生育部门开展胎儿性别的鉴定工作.

关键词：小体石碳酸碳酸复红 barr Carbolfuchsin 染色法胎儿性别

应用羊水细胞barr小体、y小体预测胎儿性别113例报告

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海南卫生 1980年 33-35页

自1956年 FuChs 等用羊水细胞预测性别以来,国内外不少学者在这方面行进了深入的研究。1978年我们学习鞍钢铁东医院对早期妊娠胎儿性别的预测方法后,对50例妊娠45～70天,要求人工流产术者,术前行绒毛细胞 barr 小体、y 小体检查,经术后... 详细信息

自1956年 FuChs 等用羊水细胞预测性别以来,国内外不少学者在这方面行进了深入的研究。1978年我们学习鞍钢铁东医院对早期妊娠胎儿性别的预测方法后,对50例妊娠45～70天,要求人工流产术者,术前行绒毛细胞 barr 小体、y 小体检查,经术后保留胚胎验证,符合率达98%。但该法未能解决中期妊娠胎儿的预测。据根本地实际情况,我们参考了有关文献后,1979年6月开始,又应用羊水细胞 barr 小体、y 小体 y 对妊娠14～32周要求引产者110例和要求选择胎儿性别的门诊病人3例,进行胎儿性别预测,经娩出后验证,符合率达100%,现介绍如下:

关键词：小体胞核 barr 羊水细胞胎儿性别