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Cellular and Molecular Mechanisms Underlying Arterial baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

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Neuroscience Bulletin 2019年第1期35卷 98-112页

作者： Huiyin Tu Dongze Zhang Yu-Long Li Department of Emergency Medicine University of Nebraska Medical CenterOmahaNE 68198USA

Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and *** in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances(such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.

关键词： Cardiovascular disease Diabetes Baroreflex baroreceptor Vascular wall Mechanosensitive ion channels Voltage-gated ion channels Angiotensin Ⅱ Superoxide Nuclear factor-kappa B

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Capsaicin facilitates carotid sinus baroreceptor activity in anesthetized rats

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Acta Pharmacologica Sinica 2004年第11期 55-59页

作者： Hao ZHANG, Yi-xian LIU, Yu-ming WU, Ze-min WANG, Rui-rong HEDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University, Shijiazhuang 050017,China

AIM: To study the effect of capsaicin on carotid sinus baroreceptor activity (CBA). METHODS: The functional curve of carotid baroreceptor (FCCB) was constructed and the functional parameters of carotid sinus baroreceptor were measured by recording sinus nerve afferent discharge in anesthetized rats with perfused isolated carotid sinus. RESULTS: Low-concentration of capsaicin (0.2 μmol/L) had no significant effect on CBA, while perfusion of the isolated carotid sinus with middle-concentration of capsaicin (1 μmol/L) could shift FCCB to the left and upward, with peak slope (PS) increased from (2.47 %±0.14 %)/mmHg to (2.88 %±0.10 %)/mmHg (P<0.05) and peak integral value of carotid sinus nerve discharge (PIV) enhanced from 211 %±5 % to 238 %±6 % (P<0.01). The threshold pressure (TP) and saturation pressure (SP) were significantly decreased from 68.0±1.1 to 62.7±1.0 mmHg (P<0.01) and from 171.0±1.6 to 165.0±0.6 mmHg (P<0.01). By perfusing with high-concentration of capsaicin (5μmol/L), FCCB was shi

关键词： capsaicin carotid sinus baroreceptor ruthenium red glibenclamide

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Place of baroreceptor activation therapy in the treatment of resistant hypertension

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World Journal of Hypertension 2016年第1期6卷 36-40页

作者： Gian Paolo Rossi Matteo Azzolini Clinica dell’Ipertensione Arteriosa Department of Medicine-DIMED University of Padua

This mini review describes the development of the therapeutic concept of baroreceptor stimulation over the last fifty years alongside the more recent introduction of it for the treatment of drug- resistant hypertension. The pros and cons of this strategy of treatment over renal sympathetic denervation are also discussed in the light of the results of the studies done in the last decade.

关键词： Resistant hypertension Treatment baroreceptor stimulation Renal denervation

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Achieving control of resistant hypertension:Not just the number of blood pressure medications

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World Journal of Hypertension 2019年第1期9卷 1-16页

作者： Kara Schmidt William Kelley Steven Tringali Jian Huang Department of Internal Medicine University of California San Francisco-Fresno Medical Education Program Medicine Service VA Central California Health Care System

Resistant hypertension(RH) has a prevalence of around 12% and is associated with an increased risk of cardiovascular disease, progression to end-stage renal disease, and even mortality. In 2017, the American College of Cardiology and American Heart Association released updated guidelines that detail steps to ensure proper diagnosis of RH, including the exclusion of *** modifications, such as low salt diet and physical exercise, remain at the forefront of optimizing blood pressure control. Secondary causes of RH also need to be investigated, including screening for obstructive sleep apnea. Notably, the guidelines demonstrate a major change in medication management recommendations to include mineralocorticoid receptor antagonists. In addition to advances in medication optimization, there are several device-based therapies that have been showing efficacy in the treatment of RH. Renal denervation therapy has struggled to show efficacy for blood pressure control, but with a redesigned catheter device, it is once again being tested in clinical trials. Carotid baroreceptor activation therapy(BAT) via an implantable pulse generator has been shown to be effective in lowering blood pressure both acutely and in longterm follow up data, but there is some concern about the safety profile. Both a second-generation pulse generator and an endovascular implant are being tested in new clinical trials with hopes for improved safety profiles while maintaining therapeutic efficacy. Both renal denervation and carotid BAT need continued study before widespread clinical implementation. Central arteriovenous anastomosis has emerged as another possible therapy and is being actively explored. The ongoing pursuit of blood pressure control is a vital part of minimizing adverse patient outcomes. The future landscape appears hopeful for helping patients achieve blood pressure goals not only through the optimization of antihypertensive medications but also through device-bas

关键词： Resistant hypertension Pseudoresistance Mineralocorticoid receptor antagonists Device-based hypertension treatment Renal denervation Carotid baroreceptor activation therapy Central arteriovenous anastomosis

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A Bio-Hydraulic Modelling Approach to Control the Hemodialysis Patient Status—Calculus and Validation

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Open Journal of Fluid Dynamics 2013年第3期3卷 205-213页

作者： Mohamed Habib Sellami Laboratory of Thermal Radiation Department of Physics Faculty of Science Tunis University Tunis El Manar Tunis Tunisia High School for Rural Engineering University of Jendouba Jendouba Tunisia Tunisian Association of Science Technology and Development Tunisia

We have developed a model permitting the control of the hemodialysis patient status. We have represented the functioning of each body compartment by a set of differential equations that express the mass balance of the carbonate and bicarbonate concentrations in each one. Experimental data from bibliography were analyzed and compared to our calculus. Results were well satisfying.

关键词： Systolic Pressure Sympathetic Activity baroreceptor Biomarker Glomarular Filtration Rate

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