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Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi Feng Yang Haifeng Tian Pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe cases.In this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser sintering.The results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant site.The accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative damage.This antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E.coli)and Gram-positive Staphylococcus aureus(S.aureus).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

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Surface modification of titanium implants with micro–nanotopography and NIR photothermal property for treating bacterial infection and promoting osseointegration

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Rare Metals 2022年第2期41卷 673-688页

作者： Yao Ding Zhang Yuan Jin-Wei Hu Kun Xu Hong Wang Peng Liu Kai-Yong Cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Teaching Affairs Department Chongqing Normal UniversityChongqing 401331China

A double acid corrosion and subsequent hydrothermal treatment were used to fabricate a micro–nano-structured Ti substrates(Ti–M–N).Afterward,the mesoporous polydopamine(MPDA)nanoparticles as photothermal agent were prepared and immobilized on the surface of Ti–M–N samples,in order to obtain Ti–M–NMPDA sample.Unique micro–nanostructure properties and the photothermal effect of the modified Ti implant caused physical stress on the bacteria and the bacterial membrane damage,and eventually led to bacteria death.More importantly,based on excellent bioactivity and cytocompatibility of mussel-inspired materials,MPDA promoted adhesion,proliferation and osteogenic differentiation of mesenchymal stem cells in vitro.Furthermore,animal experiments in vivo further confirmed that the modified Ti implants could enhance osseointegration.

关键词： Titanium implants bacterial infection Osseointegration Photothermal therapy Micro–nanotopography

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bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study

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World Journal of Gastroenterology 2020年第6期26卷 645-656页

作者： Zhu-Jun Cao Yu-Han Liu Chuan-Wu Zhu Shan Yin Wei-Jing Wang Wei-Liang Tang Gang-De Zhao Yu-Min Xu Lu Chen Tian-Hui Zhou Ming-Hao Cai Hui Wang Wei Cai Shi-San Bao Hai Li Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghai 201801China Discipline of Pathology School of Medical Sciences and Bosch InstituteUniversity of SydneySydneyNSW 2006Australia

BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.

关键词： Hepatitis B virus Cirrhosis Decompensation bacterial infection Acute-onchronic liver failure Survival

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The value of the infectionS scoring system in identifying bacterial infections among patients presenting at the emergency department of a middle-income country:A pilot study

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Chinese Journal of Traumatology 2024年第2期27卷 77-82页

作者： Dooshanveer C.Nuckchady Department of Internal Medicine Victoria HospitalCandosMauritius

Purpose:To investigate which scoring system is the most accurate tool in predicting mortality among the infected patients who present to the emergency department in a middle-income country,and to validate a new scoring system to predict bacterial infections.Methods:This was a retrospective,single-center study among patients who were admitted via the emergency department of a public hospital.All patients who were started on antibiotics were included in the study,while patients agedbacterial infections.The area under the receiver operating characteristic(AUROC)was computed for each scoring model.Results:In total,109 patients were included in this study.The quick sequential organ failure assessment(qSOFA),search out severity and rapid acute physiology score had the highest AUROC(≥0.89)for predicting mortality,while qSOFA and universal vital assessment were the simplest scoring systems with an AUROC>0.85;however,these scoring systems failed to predict whether patients were truly infected.The infectionS(short for impaired mental status,not conscious,fast heart rate,elevated creatinine,high temperature,on inotrope,low oxygen,high neutrophils and high sugar)model reached an AUROC of 0.88 to more accurately predict the infectious state of a patient.Conclusions:Middle-income countries should use the qSOFA or universal vital assessment score to identify the sickest patients in emergency department.The infectionS score may help recognize patients with bacterial infections,but it should be further validated in multiple countries prior to widely use.

关键词： Prognosis Mortality bacterial infection infectionS scoring system Sequential organ failure assessment Prediction

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Retrospective study of the incidence, risk factors, treatment outcomes of bacterial infections at uncommon sites in cirrhotic patients

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World Journal of Hepatology 2024年第3期16卷 418-427页

作者： Sophie Schneitler Christina Schneider Markus Casper Frank Lammert Marcin Krawczyk Sören L Becker Matthias Christian Reichert Institute of Medical Microbiology and Hygiene Saarland UniversityHomburg 66421Germany Department of Medicine II Saarland University Medical CenterHomburg 66421Germany Health Sciences Hannover Medical SchoolHannover 30625Germany Laboratory of Metabolic Liver Diseases Department of GeneralTransplant and Liver SurgeryCentre for Preclinical ResearchMedical University of WarsawWarsaw 02-097Poland

BACKGROUND bacterial infections(BI)negatively affect the natural course of cirrhosis.The most frequent BI are urinary tract infections(UTI),pneumonia,and spontaneousbacterial peritonitis(SBP).AIM To assess the relevance of bacterial infections beyond the commonly recognized types in patients with cirrhosis and to investigate their relationship with other clinical variables.METHODS We retrospectively analyzed patients with cirrhosis and BI treated between 2015 and 2018 at our tertiary care center.BIs were classified as typical and atypical,and clinical as well as laboratory parameters were compared between the two groups.RESULTS In a cohort of 488 patients with cirrhosis,we identified 225 typical BI(95 UTI,73 SBP,72 pulmonary infections)and 74 atypical BIs,predominantly cholangitis and soft tissue infections(21 each),followed by intra-abdominal BIs(n=9),cholecystitis(n=6),head/throat BIs(n=6),osteoarticular BIs(n=5),and endocarditis(n=3).We did not observe differences concerning age,sex,or etiology of cirrhosis in patients with typical vs atypical BI.Atypical BIs were more common in patients with more advanced cirrhosis,as evidenced by Model of End Stage Liver Disease(15.1±7.4 vs 12.9±5.1;P=0.005)and Child-Pugh scores(8.6±2.5 vs 8.0±2;P=0.05).CONCLUSION Atypical BIs in cirrhosis patients exhibit a distinct spectrum and are associated with more advanced stages of the disease.Hence,the work-up of cirrhosis patients with suspected BI requires detailed work-up to elucidate whether typical BI can be identified.

关键词： bacterial infection Empirical antibiotic therapy End-stage liver disease Escherichia coli Multi-resistant pathogens

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Relationship between Intrauterine bacterial infection and Early Embryonic Developmental Arrest

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Chinese Medical Journal 2016年第12期129卷 1455-1458页

作者： Shao-FeiYan Xin-Yan Liu Yun-Fei Cheng Zhi-Yi Li Jie Ou Wei Wang Feng-Qin Li Laboratory of Microbiology Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk Assessment Beijing 100021 China Department of Obstetrics and Gynecology Peking Union Medicai College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Family-ISianning~ Tianjin Central Hosp~al of Gynecology and Obstetrics Tianjin 300052 China

Background： Early embryonic developmental arrest is the most commonly understudied adverse outcome of pregnancy. The relevance of intrauterine infection to spontaneous embryonic death is rarely studied and remains unclear. This study aimed to investigate the relationship between intrauterine bacterial infection and early embryonic developmental arrest. Methods： Embryonic chorion tissue and uterine swabs for bacterial detection were obtained from 33 patients who underwent artificial abortion （control group） and from 45 patients who displayed early embryonic developmental arrest （trial group）. Results： Intrauterine bacterial infection was discovered in both groups. The infection rate was 24.44% （11/45） in the early embryonic developmental arrest group and 9.09% （3/33） in the artificial abortion group. Classification analysis revealed that the highest detection rate for Micrococcus luteus in the early embryonic developmental arrest group was 13.33% （6/45）, and none was detected in the artificial abortion group. M. luteus infection was significantly different between the groups （P 〈 0.05 as shown by Fisher＇s exact test）. In addition, no correlation was found between intrauterine bacterial infection and history of early embryonic developmental arrest. Conelusions： IV/. luteus infection is related to early embryonic developmental arrest and might be one of its causative factors.

关键词： Artificial Abortion bacterial infection Early Embryonic Developmental Arrest Micrococcus Luteus Spontaneous Abortion

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The dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria

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International Journal of Biomathematics 2024年第3期17卷 265-287页

作者： Xing-Xing Yang Guo-Bao Zhang Ge Tian College of Mathematics and Statistics Northwest Normal University Lanzhou Gansu 730070P.R.China

In this paper,we mainly investigate the dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria.We first establish the existence of spreading speed,and show that the spreading speed coincides with the minimal wave speed of traveling wavefronts.Moreover,a lower bound estimate of the spreading speed is given.Then,we prove that the traveling wavefronts with large speeds are globally exponentially stable,when the initial perturbation around the traveling wavefronts decays exponentially asχ→-∞,but the initial perturbation can be arbitrarily large in other locations.The adopted methods are the weighted energy and the squeezing technique.

关键词： Host tissue degradation bacterial infection traveling wavefronts minimal wave speed stability

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Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan:Antibody Recruiting at Engineered bacterial Surface with Peptidoglycan Analogs

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CCS Chemistry 2024年第6期6卷 1448-1457页

作者： Yuan Xu Shihao Song Hongwei Duan Yinyue Deng Xue-Wei Liu School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570228 School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107

The emergence of microbial drug resistance,coupled with the paucity of new antibiotics poses an impending threat to public health.In this work,we drew inspiration from synthetic peptidoglycan oligomers and successfully constructed antibody-recruiting peptidoglycan analogs,2a-d,with excellent safety profiles and high efficiencies in recruiting antibodies across different conditions.Further,we demonstrated that these peptidoglycan analogs could be readily incorporated into bacteria cell walls,whereby both simple monoclonal and pooled human serum antibodies effectively congregated to the surfaceengineered bacteria,leading to the complete extermination of the engineered bacterial cells both in vitro and in vivo.Our peptidoglycan analog agents for recruiting endogenous antibodies to combat pathogenic bacteria enable further development of promising broad-spectrum immunotherapeutics.

关键词： chitosan bacterial infection endogenous antibodies bacterial surface engineering peptidoglycan analogs

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Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure

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World Journal of Gastroenterology 2020年第32期26卷 4857-4865页

作者： Su Lin Yan-Yan Yan Yin-Lian Wu Ming-Fang Wang Yue-Yong Zhu Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Liver Research Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Clinical Liver Center The 180th Hospital of People’s Liberation ArmyQuanzhou Fujian Province362100China

BACKGROUND The diagnosis of bacterial infection is difficult in patients with acute-on-chronic liver failure(ACLF).AIM To evaluate the diagnostic accuracy of widely used parameters for bacterial infection in ACLF and to develop a simple scoring system to improve diagnostic efficiency.METHODS This was a retrospective study.Procalcitonin(PCT),white blood cells(WBC),proportion of neutrophils(N%),and C-reactive protein(CRP)were examined.Logistic regression was used to select variables for the scoring models and receiver operating characteristic curve(ROC)analysis was used to evaluate the diagnostic value of different indices.RESULTS This study included 386 patients with ACLF,169(43.78%)of whom had bacterial infection on admission.The area under the ROC(AUROC)of PCT,CRP,WBC and N%for the diagnosis of bacterial infection ranged from 0.637 to 0.692,with no significant difference between them.Logistic regression showed that only N%,PCT,and CRP could independently predict infection.A novel scoring system(infection score)comprised of N%,PCT and CRP was developed.The AUROC of the infection score was 0.740,which was significantly higher than that for the other four indices(infection score vs N%,PCT,CRP,and WBC,P=0.0056,0.0001,0.0483 and 0.0008,respectively).The best cutoff point for the infection score was 4 points,with a sensitivity of 78.05%,a specificity of 55.29%,a positive predictive value of 57.91%and a negative predictive value of 76.16%.CONCLUSION The infection score is a simple and useful tool for discriminating bacterial infection in ACLF.

关键词： Acute on chronic liver failure bacterial infection Score

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Mesenchymal Stem Cells: Potential Role against bacterial infection

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Journal of Biosciences and Medicines 2022年第3期10卷 97-113页

作者： Basem Battah Department of Biochemistry and Microbiology Faculty of Pharmacy Syrian Private University (SPU) Daraa International Highway Syria

The worldwide spread of bacterial resistance makes finding new therapeutics to overcome this ongoing problem an urgent need. Mesenchymal stem cells (MSCs) exert potential inhibiting activity against bacterial infections. The antimicrobial activity of MSCs relies on direct and indirect effects by secreting paracrine factors with potential inhibiting activity against bacterial growth or stimulating the phagocytic activity of the immune cells. These effects appeared when MSCs or its secreted factors are administrated therapeutically. Therefore, MSCs based cell therapy could be considered as a novel promising strategy to enhance the antibiotic activity in multidrug resistant (MDR) infections.

关键词： Mesenchymal Stem Cells bacterial infection Antibiotic Resistance

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