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Protective effect of bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and b-lactoglobulininduced intestinal food allergy mouse models

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World Journal of Gastroenterology 2017年第12期23卷 2149-2158页

作者： Meng-Yun Liu Zhen-Yu Yang Wen-Kui Dai Jian-Qiong Huang Yin-Hu Li Juan Zhang Chuang-Zhao Qiu Chun Wei Qian Zhou Xin Sun Xin Feng Dong-Fang Li He-Ping Wang Yue-Jie Zheng Department of Respiratory Shenzhen Children's Hospital WeHealth Gene Co. Xijing Hospital The Fourth Military Medical University

AIM To determine whether oral administration of bifidobacterium infantis CGMCC313-2(b. infantis CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.METHODS Ovalbumin(OVA)-induced allergic asthma and b-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of b. infantis CGMCC313-2 during or after allergen sensitization, histopathologic changes in the lung and intestine were evaluated by hematoxylin and eosin(HE) staining. In the allergic asthma mouse model, we evaluated the proportion of lung-infiltrating inflammatory cells. OVAspecific IgE and IgG1 levels in serum and cytokine levels in bronchoalveolar lavage fluid(bALF) were also assessed. In the food allergy mouse model, the levels of total Ig E and cytokines in serum were measured.RESULTS Oral administration of b. infantis CGMCC313-2 during or after allergen sensitization suppressed allergic inflammation in lung and intestinal tissues, while the proportion of infiltrating inflammatory cells was significantly decreased in the bALF of allergic asthma mice. Moreover, b. infantis CGMCC313-2 decreased the serum levels of total Ig E in food allergy mice, and reductions in IgE and IgG1 were also observed in OVA-induced allergic asthma mice. The expression of interleukin-4(IL-4) and IL-13 in both serum and bALF was suppressed following the administration of b. infantis CGMCC313-2, while an effect on serum IL-10 levels was not observed.CONCLUSION b. infantis CGMCC313-2 inhibits the secretion of allergen-induced IgE, IL-4 and IL-13, and attenuates allergic inflammation.

关键词： bifidobacterium infantis Asthma Allergy Ovalbumin b-lactoglobulin

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