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b-dazl:A novel gene in bovine spermatogenesis

Progress in Natural Science:Materials International 2008年第10期18卷 1209-1218页

作者： Qingbo Zhang~a Qifa Li~(a,*) Jiahuang Li~b Xinfu Li~a Zhenshan Liu~a Dawei Song~a Zhuang Xie~a ~a Laboratory of Animal Reproductive Genetics and Molecular Evolution,College of Animal Science and Technology,Nanjing Agriculture University,Nanjing 210095,China ~b Pharmaceutic biotechnology Key Laboratory,College of Life Science,Nanjing University,Nanjing 210093,China Laboratory of Animal Reproductive Genetics and Molecular Evolution College of Animal Science and Technology Nanjing Agriculture University Nanjing 210095 China Pharmaceutic biotechnology Key Laboratory College of Life Science Nanjing University Nanjing 210093 China

The dazl gene plays an important role in *** and mutation of this gene has been frequently associated with the sterility in both vertebrates and ***,a cDNA containing the complete open reading frame of dazl gene,which encodes putative RRM RNA-binding protein,was isolated from bovine tissues by *** isolated gene was referred to as ***-based location analysis showed that b-dazl is located near the end of chromosome *** b-dazl gene and its vertebrate homologue shared a high nucleotide similarity (90-94%) in the coding region and in the genomic organization,each consisting of 10 exons and 9 *** protein products contained a highly conserved RNA-binding motif,a unique DAZ repeat, and PUM2 and PAbP interacting ***-PCR assay revealed that b-dazl was expressed in the testis and ***,no signals were detected in the testes of sterile male *** microstructure of the testes of sterile males showed very few spermat- ocytes but mostly somatic *** observations are consistent with the typical phenotype of testes with defective dazl expression. Subsequent gene detection studies indicated that transcription arrest might lead to a b-dazl transcript defect in testes of cattle-yaks. Our results suggest that b-dazl may be involved in spermatogenesis,and that transcription arrest of the gene is associated with male sterility in cattle-yaks.

关键词： Cattle-yak b-dazl Male sterility Sequence analysis Expression profile

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