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Control of highly pathogenic avian influenza through vaccination

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Journal of Integrative Agriculture 2024年第5期23卷 1447-1453页

作者： Xianying Zeng Jianzhong Shi Hualan Chen State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin150069China

The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to *** this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and *** addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.

关键词： avian influenza control highly pathogenic vaccination

Genetic and Molecular Characterization of H9N2 avian influenza Viruses Isolated from Live Poultry Markets in Hubei Province, Central China, 2013–2017

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Virologica Sinica 2021年第2期36卷 291-299页

作者： Zhibin Hu Fuhu Peng Zhenghui Xiong Wanpo Zhang Tingting Li Yuejun Shi Jun Xie Xin Jin Jingjing Huang Hongde Xiao Dingren Bi Nianhua Song Zili Li College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070China Hubei Center for Animal Disease Control and Prevention Wuhan 430070China

H9N2 subtype avian influenza virus(AIV)is an influenza A virus that is widely spread throughout Asia,where it jeopardizes the poultry industry and provides genetic material for emerging human *** better understand the epidemicity and genetics of H9 subtype AIVs,we conducted active surveillance in live poultry markets(LPMs)in Hubei Province from 2013 to 2017.A total of 4798 samples were collected from apparent healthy poultry and *** RT-PCR revealed that the positivity rate of influenza A was 26.6%(1275/4798),of which the H9 subtype accounted for 50.3%(641/1275)of the positive *** the 132 H9N2 viral strains isolated,48 representative strains were subjected to evolutionary analysis and *** analysis revealed that all H9N2 viral genes had 91.1%–100%nucleotide homology,clustered with genotype 57,and had high homology with human H9N2 viruses isolated from2013 to 2017 in *** a nucleotide divergence cutoff of 95%,we identified ten distinct H9N2 genotypes that continued to change over *** analysis demonstrated that six H9N2 isolates had additional potential glycosylation sites at position 218 in the hemagglutinin protein,and all isolates had I155 T and Q226 L ***,44 strains had A558 V mutations in the PB2 protein and four had E627 V mutations,along with H9N2 human infection strains A/Beijing/1/2016 and A/Beijing/1/*** results emphasize that the H9N2 influenza virus in Hubei continues to mutate and undergo mammalian adaptation changes,indicating the necessity of strengthening the surveillance of the AIV H9N2 subtype in LPMs.

关键词： avian influenza H9N2 Genetic variation Phylogenetic analysis Live poultry markets(LPMs)

Spatial transmission of avian influenza (type H5) in birds

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Integrative Zoology 2009年第4期4卷 418-425页

作者： Xinhai LI Xiaoming LIU Lei XU Zhibin ZHANG State Key Laboratory of Integrated Pest Management on Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina

Highly pathogenic avian influenza(HPAI)H5N1 continues to threaten domestic and wild birds,as well as human ***,the mechanism of spatial transmission of HPAI is still *** analyzed the current distribu-tion of HPAI occurrences based on World Organization for Animal Health reported data from 3049 sites in the world from December 2003 to June 2006,and found that these sites were spaced at distances with a frequency peak of 100–200 *** built a cellular automata model to simulate the spatial transmission process of HPAI as a function of transmission distance,variance of the transmission distance,infection rate,and transmission times(how many times HPAI transmits from one host to another before suppression).We determined that the transmis-sion distance between HPAI occurrences is approximately 100 km on the basis of historical HPAI occurrences from 2003 to 2006 in both wild and domestic *** effectively reduce the long-distance spreading of HPAI,preventing close contact between domestic birds and waterfowl within a radius of 100 km around HPAI occur-rence sites is essential.

关键词： avian influenza birds cellular automata model disease transmission H5N1.

Emergence of H5N1 highly pathogenic avian influenza in Democratic People's Republic of Korea

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Journal of Integrative Agriculture 2022年第5期21卷 1534-1538页

作者： LIU Li-ling YANG Huan-liang GUO Fu-sheng WANG Xiu-rong DENG Guo-hua SHI Jian-zhong TIAN Guo-bin ZENG Xian-ying State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China China Animal Health and Epidemiology Center Qingdao 266032P.R.China

In the past decade,there has been extensive global surveillance for highly pathogenic avian influenza(HPAI)infection in both animals and humans,however,few studies on epidemiology of avian influenza in Democratic People’s Republic of Korea(DPRK)were *** the period 2013–2014,HPAI H5N1 viruses were detected with outbreaks in domestic poultry in *** analysis revealed that the hemagglutinin gene of all samples belonged to clade 2.***.2.1c with high *** HPAI H5N1 virus found in ducks at the Tudan Duck Farm in 2013 was might introduced by migratory birds and then led to the outbreaks on neighboring chicken farms in *** data provide direct evidence for the transmission of avian influenza viruses from wild birds to waterfowl to terrestrial ***,the monitoring and control of influenza virus in ducks must be given top priority,which are essential components to prevent and control HPAI.

关键词： avian influenza H5N1 Democratic People’s Republic of Korea clade 2.3.2.1c

Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China

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Infectious Diseases of Poverty 2016年第1期5卷 499-504页

作者： Ye Zhang Shu-Mei Zou Xiao-Dan Li Li-Bo Dong Hong Bo Rong-Bao Gao Da-Yan Wang Yue-Long Shu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Key Laboratory for Medical Virology National Health and Family Planning CommissionBeijing 102206China

Background:avian influenza viruses have caused human infection and posed the pandemic *** poultry markets are considered as a source of human infection with avian influenza *** influenza routine surveillance of live poultry markets is taken annually in *** isolated the 2 H11N9 influenza virus from the surveillance *** better understand the risk caused by these new viruses,we characterize the genetic and pathogenicity of the two ***:Viral isolation was conducted with specific pathogen-free(SPF)embryonated chicken *** genome was sequenced,and phylogenetic analysis was ***:Two H11N9 viruses were identified,with all 8 segments belonging to the Eurasian *** HA,NA,M,NS and PA genes were similar to virus isolates from ducks,and the NP,PB2 and PB1 gene segments were most similar to those viruses from wild birds,indicating that the H11N9 viruses might represent reassortant viruses from poultry and wild *** HA receptor binding preference was avian-like,and the cleavage site sequence of HA showed low *** NA gene showed 94.6%identity with the novel H7N9 virus that emerged in *** was no drug resistance mutation in the M2 *** Asn30Asp and Thr215Ala substitutions in the M1 protein implied a potentially increased pathogenicity in *** viruses were low-pathogenic strains,as assessed by the standards of intravenous pathogenicity index(IVPI)***:Two reassortant H11N9 avian influenza viruses were *** viruses showed low pathogenicity to chickens in the IVPI *** health concern caused by the reassortant H11N9 viruses should be emphasized during the future surveillance.

关键词： avian influenza H11N9 Genetic characterization Reassortant

Optimal treatment strategy of an avian influenza model with latency

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International Journal of Biomathematics 2017年第5期10卷 121-141页

作者： Chairat Modnak Jin Wang Department of Mathematics Faculty of Science Naresuan University Phitsanulok 65000 Thailand Department of Mathematics University of Tennessee at Chattanooga Chattanooga TN 37403 USA

avian influenza, caused by influenza A viruses, has received worldwide attention over recent years. In this study, we formulate a mathematical model for avian influenza that includes human human transmission and incorporates the effects of infection latency and treatments. We investigate the essential dynamics of the model through an equilibrium analysis. Meanwhile, we explore effective treatment strategies to control avian influenza outbreaks using optimal control theory. Our results show that strategically deployed medical treatments can significantly reduce the numbers of exposed and infection persons.

关键词： Optimal control theory avian influenza influenza treatments

Modeling and scientific computing for the transmission dynamics of avian influenza with half-saturated incidence

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第4期11卷 1-31页

作者： Muhammad Altaf Khan Saif Ullah Yasir Khan Muhammad Farhan Informetrics Research Group Ton Duc Thang University Ho Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang University Ho Chi Minh CityVietnam Department of Mathematics University of PeshawarPakistan Department of Mathematics University of Hafr Al-Batin Hafr Al-Batin 31991Saudi Arabia Department of Mathematics Abdul Wali Khan University Mardan 23200Pakistan

This paper presents the mathematical analysis of the dynamical system for avian *** proposed model considers a nonlinear dynamical model of birds and *** half-saturated incidence rate is used for the transmission of avian influenza *** mathematical results are presented for the proposed *** local and global dynamics of each model are presented and proven that when R01,then the endemic equilibrium is stable both locally and *** numerical results obtained for the proposed model shows that influenza could be eliminated from the community if the threshold is not greater than unity.

关键词： avian influenza half-saturated incidence rate scientific computing stability analysis numerical results.

H7N9 avian influenza with first manifestation of occipital neuralgia:A case report

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World Journal of Clinical Cases 2023年第2期11卷 434-440页

作者： Jie Zhang Department of Neurology Neuromedical CenterAviation General HospitalBeijing 100012China

BACKGROUND Most of the first symptoms of avian influenza are respiratory symptoms,and cases with occipital neuralgia as the first manifestation are rarely *** SUMMARY A middle-aged patient complaining of paroxysmal pain behind the ear was admitted to our *** patient’s condition changed rapidly,and high fever,unexpected respiratory failure,and multiple organ failure developed *** patient was diagnosed with H7N9 avian influenza based on *** We believe that the etiology of occipital neuralgia is complex and could be the earliest manifestation of severe *** possibility of an infectious disease should be considered when occipital neuralgia is accompanied by *** influenza is one of these causative agents.

关键词： Occipital neuralgia avian influenza Respiratory Infectious Case report

avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling

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Journal of Genetics and Genomics 2011年第11期38卷 533-537页

作者： Jianhui Ma Qian Sun Ruifang Mi Hongbing Zhang Department of Physiology and Pathophysiology State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100005 China

Of the few avian influenza viruses that have crossed the species barrier to infect humans, the highly pathogenic influenza A （H5NI） strain has claimed the lives of more than half of the infected patients. With largely unknown mechanism of lung injury by H5N1 infection, acute respiratory distress syndrome （ARDS） is the major cause of death among the victims. Here we present the fact that HSN 1 caused autophagic cell death through suppression of mTOR signaling. Inhibition of autophagy, either by depletion of autophagy gene Beclinl or by autophagy inhibitor 3-methyladenine （3-MA）, significantly reduced H5N1 mediated cell death. We suggest that autophagic cell death may contribute to the development of ARDS in H5N1 influenza patients and inhibition of autophagy could therefore become a novel strategy for the treatment of H5N1 infection.

关键词： avian influenza H5NI Autophagy mTOR TSC2 PTEN