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Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

引用

Regenerative Biomaterials 2022年第1期9卷 202-218页

作者： Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Medical Technology and Related Equipment Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityShunde DistrictFoshanP.R.China

Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue *** jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine ***,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound ***,treatment efficacy was significantly compromised in diabetic ***,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic *** research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing ***-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic ***,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关键词： autologous regeneration factors wound healing homeostasis tissue microenvironment inflammation patterning

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