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World Journal of Clinical Cases 2022年第4期10卷 1388-1393页

作者： Yang Zhou Yi-Ling Ding Li-Juan Zhang Mei Peng Jian Huang Department of Obstetrics and Gynecology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Severe refractory anemia during pregnancy can cause serious maternal and fetal *** the cause cannot be identified in time and accurately,blind symptomatic support treatment may cause serious economic *** minor pregnancy is commonly considered uneventful,and the condition of anemia rarely progresses during *** hemolytic anemia(AIHA)is rare during pregnancy with no exact incidence *** SUMMARY We report the case of a 30-year-oldβ-thalassemia minor multiparous patient experiencing severe refractory anemia throughout *** monitored the patient closely,carried out a full differential diagnosis,made a diagnosis of direct antiglobulin test-negative AIHA,and treated her with prednisone and intravenous *** patient gave birth to a healthy full-term *** Coombs-negative AIHA should be suspected in cases of severe hemolytic anemia in pregnant patients with and without other hematological diseases.

关键词： Maternal anemia β-thalassemia minor autoimmune hemolytic anemia Direct antiglobulin test Pregnancy Case report

Iguratimod in treatment of primary Sjögren’s syndrome concomitant with autoimmune hemolytic anemia:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1286-1290页

作者： Juan Zhang Xin Wang Jing-Jing Tian Rong Zhu Rui-Xue Duo Yi-Chen Huang Hai-Li Shen Department of Rheumatology Lanzhou University Second HospitalLanzhou 730030Gansu ProvinceChina Second Clinical Medical College Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Primary Sjögren's syndrome(pSS)concomitant with autoimmune hemolytic anemia(AIHA)but without eye and mouth dryness is exceedingly ***(IGU)has been widely used in the treatment of ***,there are few reports about the application of IGU in pSS concomitant with *** SUMMARY Here,we present the case of a patient with pSS concomitant with AIHA but without eye and mouth *** patient was initially diagnosed with hyperplastic anemia and AIHA while pSS was missed,and was finally diagnosed with pSS concomitant with *** patient was treated with IGU along with prednisone and hydroxychloroquine,and her hemoglobin,reticulocytes and IgG returned to normal *** IGU was effective for and well tolerated by our patient with pSS concomitant with AIHA,and may be a promising therapy for the treatment of this disease.

关键词： autoimmune hemolytic anemia Iguratimod Primary Sjögren’s syndrome Case report

First case of IgG4-related sclerosing cholangitis associated with autoimmune hemolytic anemia

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World Journal of Gastroenterology 2014年第26期20卷 8740-8744页

作者： Hironori Masutani Kosuke Okuwaki Mitsuhiro Kida Hiroshi Yamauchi Hiroshi Imaizumi Shiro Miyazawa Tomohisa Iwai Miyoko Takezawa Wasaburo Koizumi Department of Gastroenterology Kitasato University East Hospital

To our knowledge,patients with immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)associated with autoimmune hemolytic anemia(AIHA)have not been reported *** patients with IgG4-SC have autoimmune pancreatitis(AIP)and respond to steroid ***,isolated cases of IgG4-SC are difficult to *** describe our experience with a patient who had IgG4-SC without AIP in whom the presence of AIHA led to *** patient was a73-year-old man who was being treated for *** dysfunction was diagnosed on blood tests at another *** studies suggested the presence of carcinoma of the hepatic hilus and primary sclerosing cholangitis,but a rapidly progressing anemia developed *** the diagnosis of AIHA,steroid treatment was begun,and the biliary stricture ***4-SC without AIP was thus diagnosed.

关键词： IgG4-related sclerosing cholangitis Immunoglobulin G4-related sclerosing cholangitis autoimmune hemolytic anemia autoimmune hemolytic anemia autoimmune pancreatitis

Refractory autoimmune hemolytic anemia in a patient with systemic lupus erythematosus and ulcerative colitis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2286-2292页

作者： Dai-Xing Chen Yue Wu Sui-Feng Zhang Xiao-Jun Yang Department of Digestive System Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

BACKGROUND Ulcerative colitis(UC)and systemic lupus erythematosus(SLE)are both systemic immunoreactive diseases,and their pathogenesis depends on the interaction between genes and environmental *** are no reports of UC with SLE in China,but six cases of SLE with UC have been reported in *** combination of these two diseases has distinct effects on the pathogenesis of both *** SUMMARY A female patient(30 years old)came to our hospital due to dull umbilical pain,diarrhea and mucous bloody stool in August 2018 and was diagnosed with *** symptoms were relieved after oral administration of mesalazine(1 g po tid)or folic acid(5 mg po qd),and the patient were fed a control *** June 24,2019,the patient was admitted for treatment due to anemia and *** hospitalization,the patient had repeated low-grade fever and a progressively decreased Hb *** tests revealed positive antinuclear antibody test,positive anti-dsDNA antibody,0.24 g/L C3(0.9-1.8 g/L),0.04 g/L C4(0.1-0.4 g/L),32.37 g/L immunoglobulin(8-17 g/L),and 31568.1 mg/24 h total 24-h urine protein(0-150 mg/24 h).The patient was diagnosed with SLE involving the joints,kidneys and blood *** reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for *** The patient was discharged in remission after a series of treatments,such as intravenous methylprednisolone sodium succinate,intravenous human immunoglobulin,cyclophosphamide injection,and plasma *** discharge,the patient took oral prednisone acetate tablets,cyclosporine capsules,hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month,after which the patient's condition continued to improve and stabilize.

关键词： Plasma exchange autoimmune hemolytic anemia Systemic lupus erythematosus Ulcerative colitis Case report

Infantile giant cell hepatitis with autoimmune hemolytic anemia

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World Journal of Hepatology 2021年第4期13卷 411-420页

作者： Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Department of Medicine Nazarbayev University School of MedicineNur-Sultan 010000Kazakhstan Department of Pediatrics National Research Center for Maternal and Child HealthNur-Sultan 010000Kazakhstan

Giant cell hepatitis(GCH)is characterized by large and multinucleated(syncytial)hepatocytes in the context of liver *** GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune *** etiology is unknown;concomitant viral infections(as potential trigger factors)have been identified in a few *** pathogenesis reportedly relies upon immune-mediated/autoimmune *** condition should be considered in any infant developing Coombs-positive anemia;indeed,anemia usually precedes the development of *** clinical course is usually aggressive without the appropriate immunosuppressive therapy,which may include steroids,conventional immunosuppressors(e.g.,azathioprine and cyclophosphamide as first-line treatments),intravenous immunoglobulin,and biologics(rituximab).Improvements in medical management(including the availability of rituximab)have significantly reduced the mortality of this condition in the last decade.

关键词： Giant cell hepatitis autoimmune hemolytic anemia Rituximab Infantile hepatitis Jaundice Hyperbilirubinemia

Clinical and serological characterization of autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation

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Chinese Medical Journal 2014年第7期127卷 1235-1238页

作者： Yang Zhen Wu Bangzhao Zhou Youning Wang Wenjuan Chen Suning Sun Aining Wu Depei Xu Yang Jiangsu Institute of Hematology Key laboratory of Thrombosis and Hemostasis Ministry of Health The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background autoimmune hemolytic anemia （AIHA） is an uncommon complication of allogeneic hematopoietic stem cell transplantation （allo-HSCT） which has only been reported in a few *** here aimed to explore its *** We retrospectively analyzed 296 patients who underwent allo-HSCT in our center from July 2010 to July *** manifestations were carefully reviewed and the response to currently available treatment approaches were *** survival and risk factors of AIHA patients after allo-HSCT were further *** Twelve patients were diagnosed with AIHA at a median time of 100 days （15-720 days） after *** incidence of AIHA after allo-HSCT was 4.1％.IgG antibody were detected in ten patients and IgM antibody in two *** two cold antibody AIHA patients had a better response to steroid corticoid only treatment and the ten warm antibody AIHA patients responded to corticosteroid treatment and adjustment of immunosuppressant *** was shown to be effective for AIHA patients who failed conventional *** analysis showed that the combination of AIHA in allo-HSCT patients hinted at poor *** （CMV） infection,graft-versus-host disease （GVHD） and histocompatibility leukocyte antigen （HLA） mismatch seemed to increase the risk of developing *** Patients who develop AIHA after allo-HSCT have poor survival compared to non-AIHA *** risk factors of AIHA are CMV infection,GVHD,and HLA *** is likely to be the effective treatment choice for the refractory patients.

关键词： autoimmune hemolytic anemia allogeneic hematopoietic stem cell transplantation graft-versus-host disease

Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus

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World Journal of Nephrology 2015年第2期4卷 213-222页

作者： Junichi Fujii Toshihiro Kurahashi Tasuku Konno Takujiro Homma Yoshihito Iuchi Department of Biochemistry and Molecular Biology Graduate School of Medical ScienceYamagata University Department of Biological Chemistry Faculty of AgricultureYamaguchi University

The kidneys and the blood system mutually exert infuence in maintaining homeostasis in the body. Because the kidneys control erythropoiesis by producing erythropoietinand by supporting hematopoiesis, anemia is associated with kidney diseases. anemia is the most prevalent genetic disorder, and it is caused by a deficiency of glucose 6-phosphate dehydrogenase （G6PD）, for which sulfhydryl oxidation due to an insufficient supply of NADPH is a likely direct cause. Elevated reactive oxygen species （ROS） result in the sulfhydryl oxidation and hence are another potential cause for anemia. ROS are elevated in red blood cells （RBCs） under superoxide dismutase （SOD1） defciency in C57BL/6 mice. SOD1 defcient miceexhibit characteristics similar to autoimmune hemolytic anemia （AIHA） and systemic lupus erythematosus （SLE） at the gerontic stage. An examination of AIHA-prone New Zealand Black （NZB） mice, which have normal SOD1 and G6PD genes, indicated that ROS levels in RBCs are originally high and further elevated during aging. Transgenic overexpression of human SOD1 in erythroid cells effectively suppresses ROS elevation and ameliorates AIHA symptoms such as elevated anti-RBC antibodies and premature death in NZB mice. These results support the hypothesis that names oxidative stress as a risk factor for AIHA and other autoimmune diseases such as SLE. Herein we discuss the association between oxidative stress and SLE pathogenesis based mainly on the genetic and phenotypic characteristics of NZB and New Zealand white mice and provide insight into the mechanism of SLE pathogenesis.

关键词： autoimmune hemolytic anemia Systemic lupus erythematosus Red blood cells New Zealand black mice New Zealand white mice

Acute kidney injury following autoimmune hemolytic anemia due to simultaneous use of ciprofloxacin and hydrochlorothiazide:A case report and review of the literature

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Rheumatology & Autoimmunity 2023年第1期3卷 56-62页

作者： Fatemeh Yaghoubi Farnaz Tavakoli Davood Dalil Hoda Jamaloo Nephrology Research Center Shariati HospitalTehran University of Medical SciencesTehranIran Student Research Committee Faculty of MedicineShahed UniversityTehranIran

Introduction:Rare cases of autoimmune hemolytic anemia(AHA)associated with using ciprofloxacin or hydrochlorothiazide(HCTZ)alone have been reported ***,simultaneous use of both drugs could lead to a severe clinical *** study presents the combination of acute kidney injury(AKI)and AHA following the simultaneous use of ciprofloxacin and HCTZ for three *** Description:A 42-year-old Iranian woman presented to the emergency department with symptoms of fatigue,lethargy,nausea and vomiting,ataxia,oliguria,dark urine,and *** patient reported using HCTZ due to high blood pressure and ciprofloxacin for a urinary tract infection three days before *** laboratory findings revealed hemolytic anemia with a hemoglobin of 7 g/dl,the strongly positive direct and indirect Coombs test,high level of lactate dehydrogenase(820 IU/L),and hyperbilirubinemia(total:3 mg/dL and direct:1.2 mg/dL).Furthermore,hyperkalemia(5.2 mEq/L),hyperphosphatemia(6.2 mg/dL),high levels of BUN(100 mg/dL),and creatinine rise(6.8 mg/dL)were *** analysis showed 2+blood,4-6 red blood cells,and cola-colored *** on the findings,druginduced AHA,followed by AKI,was ***,the drugs were stopped and steroid therapy was *** patient underwent four sessions of hemodialysis to improve the ***:Healthcare providers should be aware of the life-threatening adverse effects of commonly used drugs such as ciprofloxacin or *** timely diagnosis of the offending drugs leads to avoiding the persistence of the risk factor and the deterioration of the patient's clinical condition.

关键词： acute kidney injury autoimmune hemolytic anemia ciprofloxacin hydrochlorothiazide