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第三届免疫学博士生论坛

作者：钱柳 Hong Zhou Congfeng Xu Yanyun Zhang 上海交通大学医学院 Shanghai Institute of Immunology Institutes of Medical Sciences Shanghai Jiao Tong University School of Medicine (SJTUSM) and Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & SJTUSM

Metabolic demands are dramatically different in distinct activated status and subsets of CD4+ T cells, during which mammalian target of rapamycin(m TOR) is of indispensable importance as both a sensor of external environment and a regulator on multiple downstream signaling cascades. Elaborated regulation of m TOR is vital for appropriate T cell function, and micro RNAs(mi RNA) could have potential role on that process, however, there are only superficial touch in that perspective. In the present study, with the assistance of bioinformatics, we identified mi R-99 a as a powerful regulator of m TOR, and in turn modulating glycolysis of CD4+ T cells. Further exploration demonstrated that TGF-β upregulates mi R-99 a and reprograms cellular glycolysis, through meddling m TOR signaling, thus contributes to the inhibition of Th1 differentiation and in favor of Treg induction. Deregulation of glycolysis contributes to the pathogenesis of rheumatoid arthritis(RA), and our data did show that mi R-99 a was dramatically decreased in CD4+ T cells of RA patients, potentially leading to higher glycolysis. In conclusion, we identified mi R-99 a, a novel regulator of m TOR function, which essentially regulates T cell biology through glycolysis manipulation, providing a potential therapeutic approach on autoimmune diseases.

关键词： m TOR mi R-99a glycolysis T cell differentiation TGF-β autoimmune disease

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Association of Rare and Common Variants with Juvenile Idiopathic Arthritis

Association of Rare and Common Variants with Juvenile Idiopa...

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第十四届全国免疫学学术大会

作者： Jin Li Xinyi Meng Jie Yang Tianjin Medical University

Juvenile idiopathic arthritis(JIA) is the most common pediatric rheumatic disease and is one of the most common chronic autoimmune diseases among *** remains to be understood about JIA etiology and the number of JIA genetic loci that have been reported is very limited compared to that of rheumatoid arthritis,the adult counterpart of JIA,though genetics makes large contributions to the development of JIA based on heritability *** aimed to identify rare coding variants and common single nucleotide polymorphism(SNPs) associated with JIA at the genome-wide *** rare variant study,we established a rare variant calling and filtering pipeline based on RNA-seq *** performed rare coding variant and gene-based association analyses on three RNA-seq datasets composed of 228 JIA patients in the Gene Expression Omnibus against different sets of *** identified 66 recurrent rare coding variants only present in JIA patients but not *** these variants three were reported in literature as JIA causal variants and 10 were replicated in our replication study using whole-exome sequencing data of JIA *** the common variant study,we attempted to tackle unknown molecular mechanisms of JIA underlying its heterogeneous clinical phenotypes by systematically identifying genetic signatures of each JIA subtypes with a heterogeneity sensitive *** identified 11 novel genome-wide significant loci from previously published GWAS *** annotation and pathway analysis suggest that candidate genes at these loci are highly expressed in immune cell types and function in Th17 cell *** on the association between these loci and each JIA subtype,the 7 JIA subtypes could be classified into two groups,reflecting their autoimmune vs autoinflammatory nature *** of the candidate genes in these JIA loci are targets of drugs used in clinic,with known medications used for other inflammation *** ident

关键词： Juvenile idiopathic arthritis autoimmune disease rare variants common SNPs,genetic association

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An innovative vaccine composed of the BAFF protein containing a unnatural amino acid triggers the production of auto-antibodies against endogenous BAFF and alleviates collagen-induced arthritis

An innovative vaccine composed of the BAFF protein containin...

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第十一届全国化学生物学学术会议

作者： Bo Zhang Yi Chen Yan Wang Jia-qi Sun Demin Zhou Xuan Zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

B cell-activating factor（BAFF） plays a fundamental role in B lymphocyte survival and homeostasis, and aberrant BAFF signalling is closely related to numerous autoimmune disorders. Although passive immunization strategies using monoclonal antibodies and engineered receptors have achieved success in treating autoimmune diseases, disadvantages, including the cost of continuous administration and potential immunogenicity, still exist. Here, we report an innovative active anti-BAFF vaccine that was developed through the site-specific incorporation of the unnatural amino acid p-nitrophenylalanine（p NO2-Phe） in soluble murine BAFF（DmBAFF）. It triggered a humoral immune response against endogenous BAFF and successfully alleviated collagen-induced arthritis in a murine *** vaccination with DmBAFF containing pNO2 Phe at Y91 or Y139 significantly reduced the arthritis incidence and joint inflammation compared with DmBAFF but did not obviously affect T and B cell subpopulations. Based on these data collectively, active vaccination with BAFF containing the site-specific incorporation of pNO2-Phe is an effective and relatively safe treatment option for autoimmune arthritis.

关键词： BAFF immune tolerance autoimmune disease unnatural amino acid vaccine

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Selective immunoglobulin A deficiency in Zhejiang Province

Selective immunoglobulin A deficiency in Zhejiang Province

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2019年浙江省检验医学学术大会

作者： Jinlin Liu zhejiang provincial people’s hospital

Background: Selective immunoglobulin A deficiency(SIgAD) is the most common primary antibody deticiency, is a humoral immunodeficiency disease. There are no published large-scale epidemiologic studies on SIgAD in China. The aim of our study was to investigate the prevalence and clinical manifestation in ***: We investigated 555180 residents(age>4 years) who had tested serum immunoglobulin A,G,M for any reason in 9 centers of Zhejiang ***: The prevalence of SIgAD was 133/555180(0.024%) who were subjected to immunological *** 133 individuals were detected as IgA deficient with the male to female ratio of 1:1.25, included 25 children. The most common clinical features were lower and upper respiratory tract infection(32.59%), autoimmune disorders were found in a high prevalence(31.58%),Allergic diseases account for only a small part and the rate was 3.75%.Conclusion: This is the first time to adopt a multicenter and large-scale study of SIgAD patients in China. Detailed description of the prevalence and clinical manifestations of SIgAD.

关键词： Selective IgA deficiency Infection autoimmune disease Allergic disease

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Receptor editing of phospholipase Cγ-2 on B cells and clinical application

Receptor editing of phospholipase Cγ-2 on B cells and clini...

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第十二届全国免疫学学术大会

作者： Zhang Yaling Niu Zhuoya Wang Shiwei Jia Qian Yao Zhiyan Liu Wei Hebei Medical University Public Health College Hebei General Hospital Physical Examination Center Laboratory Hebei Medical University Basic Medical College Department of Immunology Key Laboratory of Immune Mechanisms and Intervention for Major Diseases in Hebei Province

Receptor editing is the main mechanism of B cells in the development of immune tolerance,a large number of studies have shown that abnormalities in receptor editing are associated with the pathogenesis of malignancies,autoimmune diseases and immunodeficiency disorders,in which,phospholipase Cγ-2(PLCγ2) is an important molecule of the pre-BCR and BCR receptor transduction pathways and plays a regulatory role in receptor *** clearing phospholipase Cγ-2 on the role of receptor editing Mechanism can provide a theoretical basis for early clinical diagnosis and treatment of related *** paper aims at the latest research progress at home and abroad,and reviewing the mechanism and clinical application of phospholipase Cγ2 in receptor editing.

关键词： PLCγ-2 Receptor editing autoimmune disease Chronic lymphocytic leukemia

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A Genetic Study on Myasthenia Gravis

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中国临床神经科学 2000年第Z1期8卷 50-页

作者： Lu Chuan-Zhen Zhou Zhigang Wu Yongqin Institute of Neurology Shanghai medical University 200040 Shanghai China Institute of Neurology Shanghai medical University 200040 Shanghai China Institute of Neurology Shanghai medical University 200040 Shanghai China

　　Myasthenia Gravis is considered as an autoimmune disease caused by circulating ant:bodies against acetylcholine receptor(AchR) at neuromuscular junctions. Although thousands of studies in the field of function of AchR, activation passway of immune response on MG, genetic control of o-subunit of AchR have been done in the world since 1970's, it is still unclear what is the initial factor of autoimmune response and what hind of genes control are in MG patients.……

关键词： Myasthenia Gravis autoimmune disease immune response the world

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RECENT ADVANCES OF STUDY ON MYASTHENIA GRAVIS

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中国临床神经科学 2000年第Z1期8卷 20-页

作者： Xu X-H Guo H Zhang H Wang H Zhang X-H Liu G-H Peng D-T Wen S-G Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China Department of Neurology Beijing Hospital Beijing 100730 PR China

　　Myasthenia Gravis (MG) is an autoimmune disease mainly involving the acetylcholine receptor (AChRAb) at post-synaptic membrane of neuromuscular junction (NM J).……

关键词： acetylcholine receptor autoimmune disease

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