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Donor's site evaluation after restoration with autografts or synthetic plugs in rabbits

World Journal of Orthopedics 2014年第4期5卷 550-556页

作者： Konstantinos S Intzoglou Dimitrios S Mastrokalos Dimitrios S Korres Kleo Papaparaskeva Dimitrios Koulalis George C Babis Laboratory for Research of the Musculoskeletal System University of Athens Maroussi 14561 Greece 3rd Ortopaedic University Department "K.A.T." Hospital Maroussi Athens 14561 Greece 1st Orthopaedic University Department "ATTIKON" Hospital Haidari Athens 12462 Greece Pathology department Konstantinopouleion Hospital Nea Ionia Athens 14233 Greece

AIM: To investigate donor site's area histological and immunohistochemical knee cartilage appearances after resurfacing iatrogenic defects with biosynthetic plugs orautografts. METHODS: Thirty New Zealand White rabbits were used in this study. A full-thickness cylindrical defect of 4.5 mm(diameter) × 7 mm(depth) was created with a hand drill in the femoral groove of every animal. In Group A(n = 10) the defect of the donor site was re-paired with a biosynthetic osteochondral plug, in Group B(n = 10) with an osteochondral autograft, while in Group C(control group of 10) rabbits were left untreated. RESULTS: Twenty-four weeks postoperatively, smooth articular cartilage was found macroscopically in some trocleas' surfaces; in all others, an articular surface with discontinuities was observed. Twenty-eight out of 30 animals were found with predominantly viable chondrocytes leaving the remaining two-which were found only in the control group- with partially viable chondrocytes. However, histology revealed many statistical differences between the groups as far as the International Cartilage Repair Society(ICRS) categories are concerned. Immunofluoresence also revealed the presence of collagen Ⅱ in all specimens of Group B, whereas in Group A collagen Ⅱ was found in less specimens. In Group C collagen Ⅱwas not found. CONCLUSION: The matrix, cell distribution, subchondral bone and cartilage mineralization ICRS categories showed statistically differences between the three groups. Group A was second, while group B received the best scores; the control group got the worst ICRS scores in these categories. So, the donor site area, when repairing osteochondral lesions with autografting systems, is better amended with osteochondral autograft rather than bone graft substitute implant.

关键词： autografts Synthetic plug Osteochondral defects Rabbit model animal study Donor site Immunofluoresence Histological evaluation International Cartilage Repair Society score

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Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

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Neural Regeneration Research 2021年第5期16卷 871-877页

作者： Daniel J.Hellenbrand Clayton L.Haldeman Jae-Sung Lee Angela G.Gableman Elena K.Dai Stephen D.Ortmann Jerrod CGotchy Kierra K.Miller Adrianna M.Doucas Nicole C.Nowak William L.Murphy Amgad S.Hanna Department of Neurological Surgery University of WisconsinMadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin Madison WIUSA

The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve,is to incorporate an autologous nerve ***,even with the incorporation of a nerve graft,generally patients only regain a small portion of function in limbs affected by the ***,there has been some promising results using growth factors to induce more axon growth through the nerve graft,many of these previous therapies are limited in their ability to release growth factors in a sustained manner and tailor them to a desired time *** ideal drug delivery platform would deliver growth factors at therapeutic levels for enough time to grow axons the entire length of the nerve *** hypothesized that mineral coated microparticles(MCMs)would bind,stabilize and release biologically active glial cell-derived neurotrophic factor(GDNF)and nerve growth factor(NGF)in a sustained ***,the objective of this study was to test the ability of MCMs releasing growth factors at the distal end of a 10 mm sciatic nerve graft,to induce axon growth through the nerve graft and restore hind limb *** sciatic nerve grafting in Lewis rats,the hind limb function was tested weekly by measuring the angle of the ankle at toe lift-off while walking down a *** weeks after grafting,the grafts were harvested and myelinated axons were analyzed proximal to the graft,in the center of the graft,and distal to the *** physiological conditions in vitro,the MCMs delivered a burst release of NGF and GDNF for 3 days followed by a sustained release for at least 22 *** vivo,MCMs releasing NGF and GDNF at the distal end of sciatic nerve grafts resulted in significantly more myelinated axons extending distal to the graft when compared to rats that received nerve grafts without growth factor *** rats with nerve grafts incorporated with MCMs releasing NGF and G

关键词： autografts axon growth drug delivery glial cell-derived neurotrophic factor growth factors mineral coatings nerve grafting nerve growth factor

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Peripheral nerve regeneration with conduits:use of vein tubes

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Neural Regeneration Research 2015年第4期10卷 529-533页

作者： Rodrigo Guerra Sabongi Marcela Fernandes Joao Baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration

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rhBMP in lumber fusion for lumbar spondylolisthesis: A systematic review and meta-analysis

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Chinese Journal of Traumatology 2019年第1期22卷 51-58页

作者： Peng-Fei Han Tao-Yu Chen Zhi-Liang Zhang Xiao-Dong Li Peng-Cui Li Lei Wei Zhi Lu Xiao-Chun Wei Department of Orthopaedic The Second People's Hospital of Changzhi Changzhi Shanxi Province China Department of Orthopaedic The Second Clinical Medical College of Shanxi Medical University Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair Taiyuan Shanxi Province China

Purpose: To compare the efficacy and safety of recombinant human bone morphogenetic protein (rhBMP) and iliac crest autograft in the fusion treatment of lumbar spondylolisthesis. Methods: The studies using randomized con trolled trials to compare the rhBMP with iliac crest autograft in the treatment of lumbar spondylolisthesis were retrieved from Embase, Pubmed, ProQuest dissertations & theses (PQDT), China national knowledge infrastructure (CNKI), Chinese Biomedical Database, Wanfang Data, Cochrane Library (from March 1998 to March 2018). Postoperative fusion rate, clinical success rate, postoperative intervertebral height, complications, operation time, blood loss and duration of hospitalization were chosen as the outcome indicators. Methodological quality of the trials was critically assessed, and releva nt data were extracted. Statistical software Revman 5.3 was used for dataanalysis. Results: Eleven articles were included in the meta-analysis. The results showed that, comparing the efficacy of rhBMP with iliac crest autograft, statistical significance was found in the 24-month fusion rate post operation [95% CI (1.38, 24.70), p = 0.02] and operation time [95% CI (-14.22,-2.08), p = 0.008]. There is not sufficient evidence for statistical differences in the remaining indicators. Conclusion: The current literature shows rhBMP is a safe and effective grafting material in the treatment of lumbar spondylolisthesis. Further evidenee is dependent on the emergence of more randomized controlled trials with higher quality and larger sample sizes in the future.

关键词： Spondylolysis Bone morphogenetic proteins Ilium autografts Meta-analysis

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Osteochondral autograft transfer (mosaicplasty) for treatment of patients with osteochondral lesions of talus

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Chinese Journal of Traumatology 2020年第1期23卷 60-62页

作者： Amir Sabaghzadeh Fateme Mirzaee Heydar Shahriari Rad Fateme Bahramian Ardeshir Alidousti Hamidreza Aslani Sport Medicine and Knee Research Center Milad HospitalTehranIran Islamic Azad University of Medical Sciences QeshmIran Sport Medicine and Knee Research Center Shahid Beheshti University of Medical SciencesTehranIran

Purpose:Osteochondral lesion of talus(OLT)is one of the common causes of ankle *** disorder is common in young athletes after ankle *** are various therapeutic *** of the options is mosaic *** purpose of this study was to investigate the effect of mosaicplasty on improvement of symptoms of patients with osteochondral lesions of ***:Nineteen patients with osteochondral lesions of talus participated in this study,who were treated with *** and after treatment,pain(visual analogue scale),function(American Orthopaedic Foot and Ankle Society),range of motion and radiographic signs were ***:The results of this study showed that mosaicplasty could significantly reduce pain,increase function and improve radiographic *** range of motion increased after treatment,which was not ***:We can confirm the effect of mosaicplasty on the improvement of patients with osteochondral lesions of the ankle,suggesting it as a treatment option.

关键词： autografts Talus Osteochondral lesions

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