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Time-sequential changes of differentially expressed miRNAs during the process of anterior lumbar interbody fusion using equine bone protein extract, rhBMP-2 and autograft

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Frontiers of Materials Science 2014年第1期8卷 72-86页

作者： Da-Fu CHEN Zhi-Yu ZHOU Xue-Jun DAI Man-Man GAO Bao-Ding HUANG Tang-Zhao LIANG Rui SHI Li-Jin ZOU Hai-Sheng LI Cody BUNGER Wei TIAN Xue-Nong ZOU Laboratory of Bone Tissue Engineering Beijing Research Institute of Traumatology and Orthopaedics Beijing Jishuitan Hospital Beijing 100035 China Department of Spine Surgery/Orthopaedic Research Institute The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China Department of Surgery the First Affiliated Hospital of Nanchang University Nanchang 330006 China Orthopaedic Research Laboratory/The Institute of Clinical Medicine Aarhus University Hospital DK-8000 Aarhus Denmark Medicine School Shenzhen University Shenzhen 518060 China

The precise mechanism of bone regeneration in different bone graft substitutes has been well studied in recent researches. However, miRNAs regulation of the bone formation has been always mysterious. We developed the anterior lumbar interbody fusion （ALIF） model in pigs using equine bone protein extract （BPE）, recombinant human bone morphogenetic protein-2 （rhBMP-2） on an absorbable collagen sponge （ACS）, and autograft as bone graft substitute, respectively. The miRNA and gene expression profiles of different bone graft materials were examined using microarray technology and data analysis, including self-organizing maps, KEGG pathway and Biological process GO analyses. We then jointly analyzed miRNA and mRNA profiles of the bone fusion tissue at different time points respectively. Results showed that miRNAs, including let-7, miR-129, m iR-21, miR-133, miR-140, miR-146, miR-184, and miR-224, were involved in the regulation of the immune and inflammation response, which provided suitable inflammatory microenvironment for bone formation. At late stage, several miRNAs directly regulate SMAD4, Estrogen receptor 1 and 5-hydroxytryptamine （serotonin） receptor 2C for bone formation. It can be concluded that miRNAs play important roles in balancing the inflammation and bone formation.

关键词： miRNA bone protein extract (BPE) recombinant human bone morphoge-netic protein-2 (rhBMP-2) autograft

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ACL reconstruction with BPTB autograft and irradiated fresh frozen allograft

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第4期10卷 306-316页

作者： Kang SUN Shao-qi TIAN Ji-hua ZHANG Chang-suo XIA Cai-long ZHANG Teng-bo YU Department of Orthopaedics Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China Healthy Physical Examination Center Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China

Objective： To analyze the clinical outcomes of arthroscopic anterior cruciate ligament （ACL） reconstruction with irradiated bone-patellar tendon-bone （BPTB） allograft compared with non-irradiated allograft and autograft. Methods： All BPTB allografts were obtained from a single tissue bank and the irradiated allografts were sterilized with 2.5 mrad of irradiation prior to distribution. A total of 68 patients undergoing arthroscopic ACL reconstruction were prospectively randomized consecutively into one of the two groups （autograft and irradiated allograft groups）. The same surgical technique was used in all operations done by the same senior surgeon. Before surgery and at the average of 31 months of follow-up （ranging from 24 to 47 months）, patients were evaluated by the same observer according to objective and subjective clinical evaluations. Results： Of these patients, 65 （autograft 33, irradiated allograft 32） were available for full evaluation. When the irradiated allografl group was compared to the autograft group at the 31 -month follow-up by the Lachman test, the anterior drawer test （ADT）, the pivot shift test, and KT-2000 arthrometer test, statistically significant differences were found. Most importantly, 87.8% of patients in the autograft group and just only 31.3% in the irradiated allograft group had a side-to-side difference of less than 3 mm according to KT-2000. The failure rate of the ACL reconstruction with irradiated allograft （34.4%） was higher than that with autograft （6.1%）. The anterior and rotational stabilities decreased significantly in the irradiated allograft group. According to the overall International Knee Documentation Committee （1KDC）, functional and subjective evaluations, and activity level testing, no statistically significant differences were found between the two groups. Besides, patients in the irradiated allograft group had a shorter operation time and a longer duration of postoperative fever. When the patients had a fever, the

关键词： Anterior cruciate ligament (ACE) reconstruction Patellar tendon autograft Allograft Irradiation Prospectiverandomized study

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A Single Bundle Anterior Cruciate Ligament Reconstruction (ACL-R) Using Hamstring Tendon autograft and Tibialis Anterior Tendon Allograft:A Comparative Study

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Current Medical Science 2018年第5期38卷 818-826页

作者： Saroj Rai Sheng-yang JIN Bimal RAI Nira TAMANG Wei HUANG Xian-zhe LIU Chun-qing MENG Hong WANG Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Trauma Center National Academy of Medical SciencesKathmandu 44600Nepal

The main purpose of this study patients undergoing a single bundle anterior was to compare the clinical outcomes of cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT)autografts and two-strand tibialis anterior (2TA) aUografts,and to find out the rate of graft failure and possible *** hypothesized that there would be no difference in the clinical outcome,and graft failure would be associated with the use of small sized allograft in young active males with high demand of sports *** retrospectively evaluated 222 patients (male,n=167,female,n=55) undergoing ACL-R between January 2010 and July *** 222 patients,115 were included in the 4HT autograft group and 107 patients in the 2TA allograft *** criteria were primary unilateral ACL-R with a minor MCL (autograft with at least 8 mm diameter should be considered in a young active male with high demand of sports activities to avoid graft failure.

关键词： anterior cruciate ligament reconstruction autograft allograft hamstring tendon tibialis anterior tendon

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Predictive factors for coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction

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World Journal of Orthopedics 2024年第11期15卷 1036-1046页

作者： Tian-Wang Zhu Xian-Xiang Xiang Chun-Hui Li Rui-Xin Li Nan Zhang Department of Sports Medicine Dalian University Affiliated Xinhua HospitalDalian 116021Liaoning ProvinceChina Department of Spine Surgery Dalian University Affiliated Xinhua HospitalDalian 116021Liaoning ProvinceChina

BACKGROUND Meniscus extrusion occurs in most elderly individuals and most patients after meniscus allograft *** risk factors and correlative factors of meniscus extrusion have been extensively ***,for using tendon autograft for meniscus reconstruction,both graft type and surgical method are different from those in previous studies on meniscus *** To identify predictive factors for coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus *** Ten patients who underwent medial meniscus reconstruction with tendon autograft were selected for this retrospective observational *** graft extrusions and potential factors were measured and correlation and regression analyses were performed to analyze their *** The medial graft extrusion correlated with the preoperative bilateral hip-kneeankle angle difference,preoperative Kellgren-Lawrence grade,preoperative relative joint space width,and preoperative bilateral medial edge incline angle *** anterior graft correlated with the anterior tunnel edge distance at 1 week after *** posterior graft extrusion correlated with the preoperative bilateral hip-knee-ankle angle difference,preoperative relative joint space width,and posterior tunnel edge distance at 1 week after *** mean graft extrusion correlated with the preoperative bilateral hip-knee-ankle angle difference and preoperative relative joint space *** preoperative joint space width and anterior and posterior tunnel edge distance at 1 week can be used to predict the medial,anterior,posterior,and mean graft extrusion *** The preoperative joint space width and tunnel position can be used to predict the coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction.

关键词： Meniscus Extrusion Reconstruction autograft Graft

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THE　REPAIR　OF　EYELID　DEFECT　WITH　FREE　HARD　PALATE　MUCOSAL　autograft

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中华眼科杂志 1996年第3期 11-15页

作者：赵光喜李冰

ＴＨＥＲＥＰＡＩＲＯＦＥＹＥＬＩＤＤＥＦＥＣＴＷＩＴＨＦＲＥＥＨＡＲＤＰＡＬＡＴＥＭＵＣＯＳＡＬＡＵＴＯＧＲＡＦＴＺｈａｏＧｕａｎｇｘｉ赵光喜ＬｉＢｉｎｇ李冰ＡｂｓｔｒａｃｔＯｂｊｅｃｔｉｖｅＴｏｉｎｖｅｓｔｉｇａｔ... 详细信息

ＴＨＥＲＥＰＡＩＲＯＦＥＹＥＬＩＤＤＥＦＥＣＴＷＩＴＨＦＲＥＥＨＡＲＤＰＡＬＡＴＥＭＵＣＯＳＡＬＡＵＴＯＧＲＡＦＴＺｈａｏＧｕａｎｇｘｉ赵光喜ＬｉＢｉｎｇ李冰ＡｂｓｔｒａｃｔＯｂｊｅｃｔｉｖｅＴｏｉｎｖｅｓｔｉｇａｔｅｔｈｅｆｒｅｅｈａｒｄｐａｌａｔ...

关键词：赵光李冰 autograft

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PERIPHERAL NERVE REPAIR IN RATS USING VASCULARIZED FROZEN IN-SITU MUSCLE autograft

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中华创伤杂志 1997年第4期13卷 73-77页

作者：王岩朱盛修解放军总医院北京香港中文大学香港

ＰＥＲＩＰＨＥＲＡＬＮＥＲＶＥＲＥＰＡＩＲＩＮＲＡＴＳＵＳＩＮＧＶＡＳＣＵＬＡＲＩＺＥＤＦＲＯＺＥＮＩＮ┐ＳＩＴＵＭＵＳＣＬＥＡＵＴＯＧＲＡＦＴＷＡＮＧＹａｎ（王岩）１，ＺＨＵＳｈｅｎｇ－ｘｉｕ（朱盛修）１，ＨＵＮＧ... 详细信息

ＰＥＲＩＰＨＥＲＡＬＮＥＲＶＥＲＥＰＡＩＲＩＮＲＡＴＳＵＳＩＮＧＶＡＳＣＵＬＡＲＩＺＥＤＦＲＯＺＥＮＩＮ┐ＳＩＴＵＭＵＳＣＬＥＡＵＴＯＧＲＡＦＴＷＡＮＧＹａｎ（王岩）１，ＺＨＵＳｈｅｎｇ－ｘｉｕ（朱盛修）１，ＨＵＮＧＬＫ２，ＬＥＵＮＧＰＣ２１．Ｄｅｐ...

关键词：王岩 USING RATS MUSCLE REPAIR VASCULARIZED IN-SITU FROZEN autograft

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autograft mediated adoptive immunotherapy of cancer in the context of autologous stem cell transplantation

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World Journal of Clinical Oncology 2010年第1期1卷 29-34页

作者： Luis F Porrata Svetomir N Markovic Division of Hematology Department of MedicineMayo Clinic College of Medicine200 First St.SWRochesterMN 55905United States

The infused stem cell autograft in autologous stem cell transplantation(ASCT)has been viewed mainly as hematologic rescue from the myelosuppressive side effect of conditioning ***,recent reports have shown that the immune effector cells collected at the same time as the stem cells can produce an autologous graft-versus-tumor effect,similar to the graft-versus-tumor effect seen in allogeneic stem cell transplantation without the detrimental effects of graftversus-host *** this article,we review the different immune effector cells collected and infused from the stem cell autograft and their association with clinical outcome post-ASCT,suggesting that ASCT can be viewed not only as a therapeutic maneuver to recover bone marrow function after deliver high-dose chemotherapy,but also as an adoptive immunotherapeutic intervention capable of eradicating residual tumor cells in patients with cancer.

关键词： Adoptive immunotherapy Autologous graft versus tumor effect autograft

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Comparison of Clinical Outcome of autograft and AIIograft Reconstruction for Anterior Cruciate Ligament Tears

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Chinese Medical Journal 2015年第23期128卷 3163-3166页

作者： Yu-Hua Jia Peng-Fei Sun Department of Orthopedics Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background： Hamstring （HS） autograft and bone-patellar tendon-bone allograft are the most common choice for reconstruction of anterior cruciate ligament （ACL）. There was a little report about the clinical outcome and difference of arthroscopic ACL reconstruction using allograft and autograft. This study aimed to compare the clinical outcome of autograft and allograft reconstruction for ACL tears. Methods： A total of 106 patients who underwent surgery because of ACL tear were included in this study. The patients were randomly divided into two groups, including 53 patients in each group. The patients in group I underwent standard ACL reconstruction with HS tendon autografts, while others in group II underwent reconstruction with bone-patellar tendon-bone allograft. All the patients were followed up and analyzed; the mean follow-up was 81 months （range： 28-86 months）. Clinical outcomes were evaluated using the International Knee Documentation Committee （IKDC）, Lysholm scores, physical instability tests, and patient satisfaction questionnaires. The complication rates of both groups were compared. Tibial and femoral tunnel widening were assessed using lateral and anteroposterior radiographs. Results： At the end of follow-up, no significant differences were found between the groups in terms of IKDC, Lysholm scores, physical instability tests, patient satisfaction questionnaires, and incidences of arthrofibrosis. Tibial and femoral tunnel widening was less in the HS tendon autografts. This difference was more significant on the tibial side. Conclusions： In the repair of ACL tears, allograft reconstruction is as effective as the autograft reconstruction, but the allograft can lead to more tunnel widening evidently in the tibial tunnel, particularly.

关键词： Allograft Anterior Cruciate Ligament autograft Reconstruction

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Five Strand Hamstring Tendon autograft for Anterior Cruciate Ligament Reconstruction Provides No Benefit over the Gold Standard Four Strand Repair for Anterior Stability of the Knee: A Prospective Cohort Study

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Open Journal of Orthopedics 2017年第6期7卷 156-172页

作者： A.Sideris A.Hamze N.Bertollo D.Broe WR Walsh Surgical and Orthopaedic Research Laboratories Prince of Wales HospitalRandwickNew South WalesAustralia Prince of Wales Clinical School UNSW MedicineUniversity of New South WalesRandwickNew South WalesAustralia Prince of Wales Orthopaedic Department Prince of Wales HospitalRandwickNew South WalesAustralia

The Four-Strand Hamstring Tendon autograft has been long established as the gold standard for surgical reconstruction of the Anterior Cruciate Ligament. Some studies have suggested wider grafts, such as a Five-Strand hamstring graft, may provide greater strength and a larger scaffold for incorporation of the graft into the bone tunnels, leading to greater postoperative anterior stability of the knee. 28 (n = 18 Four-Strand and n = 10 Five-Strand) patients with planned ACL reconstructive surgery by a single surgeon were recruited for this study. The KT-1000 Arthrometer (MED metric, CA, USA) was used to quantify AP translation in the subjects’ knees before (T0) and after surgery at 6 (T1) and 12 (T2) weeks. At 12 weeks there was significantly higher (p = 0.01) mean anterior laxity on Maximum Manual Test in the Five- Strand group (9.1 ± 1.7 mm) than the Four Strand Group (6.9 ± 2.3 mm). Further, there were significantly higher mean side-to-side differences (p = 0.01) on Maximum Manual Test in the Five-Strand cohort (5.1 ± 3.5 mm) compared to the Four-Strand cohort (1.9 ± 2.2 mm). A significantly larger positive mean change in anterior laxity (p = 0.02) from 6 - 12 weeks was evident in the Five-Strand group (1.4 ± 0.9) than the Four-Strand group (-0.3 ± 1.9 mm). No significant correlations were seen between graft widths and measures of anterior stability on KT-1000. This study illustrated that there was no benefit to using a Five-Strand Hamstring Tendon autograft when compared to the gold standard Four-Strand Repair specifically with regards to anterior stability of the knee.

关键词： Anterior Cruciate Ligament ACL Anterior Cruciate Ligament Reconstructive Surgery Anterior Cruciate Ligament Reconstruction ACL Reconstruction Five Strand Hamstring Tendon autograft Four Strand Hamstring Tendon autograft KT-1000 AP Translation Knee

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Use of Artificial Dermis and Cultured Epithelial autograft for Extensive Deep Dermal Burns —A Case Report

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Open Journal of Emergency Medicine 2018年第4期6卷 73-81页

作者： Takahiro Ueda Tomohide Matsushima Kohei Ichinohashi Yasuhide Kitazawa Department of Emergency and Critical Care Medicine Faculty of Medicine Kindai University Osaka Japan

In the treatment of extensive burns, cultured epithelial autograph (CEA) became available commercially in Japan from 2009. Based on the 6 years multicenter surveillance data on using CEA for extensive burns, it is reported that using 6:1 split thickness skin graft together with CEA is successful after wound bed preparation for extensive deep dermal burn or patients with deep burn [1].

关键词： Artificial Dermis Extensive Burn Cultured Epithelial autograft

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