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The Condyloma Acuminatum’s Recurrence Can Be Reduced by Lesional auto-transplantation

Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 242-252页

作者： Epipode Ntawuyamara Bashir Zeeshan Yuan Liang Yanhua Liang Department of Dermatology Cosmetology and Venereology Shenzhen Hospital of Southern Medical University Shenzhen China Department of Dermatology and Venereology Kamenge Teaching Hospital of University of Burundi Bujumbura Burundi Shenzhen (Nanshan) Concord College of Sino-Canada Shenzhen China

Background : Condyloma acuminatum (CA), also known as a genital wart (GW), is a sexually transmitted disease caused by human papillomavirus (HPV). HPV lesions, recurrence tendency, and risk of malignant formation are primarily dependent on the person’s immunity level. GW recurrence is a major challenge in CA treatment. The aim of this study was to explore how lesional auto-transplantation (LT) can be used to treat CA and decrease its recurrence. Methods : We treated CA through the preparation and implantation of tissue from nine CA patients in our dermatology clinic. transplantation of small pieces of HPV lesions to the subcutaneous fat of the inguinal region was carried out with the help of a simple surgical method under local anesthesia. Patients were followed up for six to eight months. We searched PubMed and the Web of Science for treatment options for CA to compare our treatment method recurrence rate with existing treatment options. Results : During three months of follow-up, seven patients experienced no recurrence of condyloma lesions, while two patients experienced recurrence of small lesions of condyloma acuminatum. The recurrence rate of CA once treated by auto-transplantation was relatively low compared to other CA treatment options. Conclusions : transplantation of HPV lesions to the inguinal area reduces the recurrence rate in sexually active individuals. The 2/9 recurrence after implantation could be due to poor hygiene, sexual relationships or immune factors.

关键词： auto-transplantation Condyloma Acuminatum Human Papillomavirus Recurrence

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Experimental study of lymph node auto-transplantation in rats

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Chinese Medical Journal 1998年第3期 47-49页

作者：干季良蔡仁祥李圣利张涤生

Objective To observe the restoration of structure and function of auto transplanted lymph nodes. Methods Inguinal lymph nodes in Spregue Dawley (SD) rats were auto transplanted by free implantation, or with an intact vascular pedicle, or by free transplantation with microvascular anastomosis, to the popliteal fossa where lymph nodes were removed. The observation methods included emission computerized tomographic (ECT) scanning, staining of China ink and methylthionine chloride to observe the histological changes. Results After four weeks, these vascularized nodes showed normal histological appearances and spontaneously reestablished afferent and efferent lymphatic reconnection with the surrounding lymphatic vessels. ECT lymphoscintigraphy with 99 mTc Dx showed that vascularized lymph nodes had restored their normal function. Conclusion Vascularized lymph node transplantation is a useful method for draining extremity lymph edema.

关键词：干季 study node rats lymph 旱季 Experimental auto-transplantation

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Histomorphological observation in arterial remodeling following New Zealand rabbit auto-extremity artery transplantation

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Journal of Nanjing Medical University 2007年第6期21卷 367-371页

作者： Yangyang Zhang Wen Ge Biao Yuan Xiaohu Zhang Kejiang Cao Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Cardio-thoracic Shanghai Shuguang Hospital Shanghai 200025China Department of Clinical Medicine Tongji University Shanghai 200331China

Objective： To investigate the histomorphological change in auto-extremity artery following transplantation. Methods： 50 New Zealand rabbits were randomly divided into 5 groups（postoperative 1 d, 3 d, 7 d, 14 d, 56 d, n = 10）. Femoral artery was harvested and end-to-side anastomosed with carotid in order to build the auto-extremity arterial graft animal model. On the postoperative 1^st, 35^nd, 7^th, 14th and 56^th days, grafts for morphometric analysis under the Image analysis system were obtained; and electron microscope was scanned to observe endothelial cells. In addition, Immunostaining of sections were performed with the mouse monoclonal antibody of the a -smooth muscle isoform of actin and proliferating cell nuclear antigen antibody. Results： Overall patency rate for all conduits was 86%.The intimal hyperplasia was first observed in the 7^th day group, and continued to increase in the 56^th day group（183.21 ± 111.74） μ m, P 〈 0.01. Additionally, the luminal narrowed（32.43 ± 18.28）% in the 56^th day group. Smooth muscle cells were the mainly hyperplastic components. The most active proliferation of cells was detected in the 14^th day group, where the extracellular matrix gradually deposited in the intima. Conclusion： Moderate intimal hyperplasia occurred in arterial conduits and vascular structure experienced constrictive remodeling after auto-transplantation.

关键词： extremity artery auto-transplantation artery remodeling rabbit

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