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Increased plasma levels of Lp(a) enhance the development of coronary atherosclerosis

沈阳药科大学学报 2008年第S1期25卷 90-91页

作者： LI Ying,XU Hong,ZHOU Qin,WANG Chang-yuan,LIU Yan-xia,Lü Yuan-yuan,FAN Jiang-lin,SUN Hui-jun(Department of Clinical Pharmacology,Dalian Medical University,Dalian 116027,China)

Objective To test the hypothesis that increased plasma levels of Lp(a)may enhance the development of atherosclerosis in the setting of *** The plasma Lp(a)was analyzed by SDS-PAGE Western blotting and quantitated using specific ELISA *** total cholesterol,triglycerides and HDL-cholesterol were determined using Wako assay *** left coronary artery was used for the evaluation of coronary atherosclerosis(stenosis %).For quantitative study of the lesions in coronary atherosclerosis,hematoxylin-eosin and Elastica-van Gieson staining were *** study cellular components(SMC ***)and Lp(a)deposits in the lesions,immunohistochemical staining was performed and then image analysis system was *** Plasma total cholesterol,triglycerides,or HDL-C were not significantly different between transgenic(Trg)and nontransgenic(nonTrg)*** rabbits had 200% increase in coronary stenosis caused by *** lesions of Trg WHHL rabbits contained more SMCs and less macrophage than those of nonTrg WHHL *** The results suggest that increased plasma levels of Lp(a)enhance the development of coronary atherosclerosis.

关键词： plasma levels of Lp(a) coronary atherosclerosi

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Effect of HDL and apo AI on PGE_2 Production by Monocyte-Derived Macrophages

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 270-272页

作者：周小琴 Arnold von Eckardstein DepartmentofInternalMedicine InstituteofClinicalChemistry&LaboratoryMedicine

Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI (apo AI) on production of prostaglandin E2 (PGE2 ) by human m onocyte- derived macrophages was *** were loaded with acetylated low density lipoprotein followed by incuba- tion with HDL3or apo ***2 produced and secreted in culture supernatant was quantified by en- zyme im ***3induced production of PGE2 by m acrophages in a time- dependent m an- ner.2 4 h after incubation,PGE2 production by HDL3- treated macrophages increased 3.7- fold of that by control *** AI also induced PGE2 secretion to 2 .1- fold,which was significantly less than *** data indicate that both HDL3and lipid- free apo AI enhance PGE2 synthesis and se- cretion by hum an m acrophages and this may further contribute to the protection from atheroscle- rosis.

关键词： prostaglandin E2 high density lipoprotein m acrophage,m onocyte- derived apolipoprotein AI atherosclerosi

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