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Cardiovascular Innovations and Applications 2016年第B9期1卷 443-450页

作者： S.Vallurupalli Yao Dai J.L.Mehta Division of Cardiology University of Arkansas for Medical SciencesLittle RockAR 72205USA Central Arkansas Veterans Healthcare System Little RockARUSA

Inflammation plays an important role in *** play a crucial role in innate immunity,which mediates the body’s response to various *** the different types of inflammasomes,NLRP3 has been implicated in atherosclerosis through the production of proinfl ammatory cytokines,IL-1β and *** review describes the role of the NLRP3 infl ammasome in atherosclerosis and discusses potential therapeutic targets in the infl ammasome pathway.

关键词： inflammasomes NLRP3 caspase 1 interleukins atheroscle

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Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications

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World Journal of Cardiology 2015年第10期7卷 609-620页

作者： Giuseppe Maiolino Valeria Bisogni Giacomo Rossitto Gian Paolo Rossi Department of Medicine - DIMED Hypertension Clinic University of Padua

atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2(Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the LpPLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed.

关键词： Lipoprotein-associated phospholipase A2 atheroscle

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