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Technical and Dosimetric Study of Four Facio-cervical Fields Conformal Radiotherapy for Nasopharyngeal Carcinoma

Chinese Journal of Biomedical Engineering(English Edition) 2015年第1期24卷 28-32页

作者： WANG Fang-zheng FU Zhen-fu WANG Lei PIAO Yong-feng HUA Yong-hong CHEN Wei-jun XU Min Department of Radiation Oncology Zhejiang Tumor Hospital

Objective: The aim of this study is to establish the methods of four facio-cervical field's conformal radiotherapy(4F-CRT) for nasopharyngeal carcinoma(NPC), and to optimize the methods for clinical practice. Materials and Methods:40 patients with untreated NPC of T1-T4(1997 AJCC Staging System) were rolled into this *** and four facio-cervical fields conform plans were designed for each patient using Pinnacle 8.0 three-dimension treatment planning system(3D-TPS)as follows: 1. Improved plan, four facio-cervical field's conform plan, anterior, posterior facio-cervical and two lateral opposing facio-cervical fields; 2. Conventional plan, two lateral opposing facio-cervical fields delivered to the target in each plan, only with the same dose dose volume histograms(DVHs) of the targets and normal organs, brain stem,spinal cord, parotid glands, and temporal mandibular joints(TMJs) were compared and the dose distribution were evaluated. Results: *** dose distribution of the improved plan could meet the requirements for the target volume. 2. There was not any significant difference in the dose of spinal cord between the two *** mean doses of Dmaxfor brain stem in conventional plan were much lower than those in the improved plan,though both were within safety limits. 3. Compared with the conventional plans, the improved plan significantly decreased the hotspot areas in the target volume and had better parotid glands and temporal mandibular joints sparing effect. Conclusion:Compared with the conventional plan, the improved plan provides satisfactory dose coverage to the tumor volume and better sparing of the parotid gland, TMJs and other normal tissues in external beam radiotherapy of NPC.

关键词： asopharyngeal neoplasms four facio-cervical fields conformal radiotherapy TPS dosimetry

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