检索结果-南通市图书馆

Targeted cancer therapies based on antibodies directed against epidermal growth factor receptor:status and perspectives

引用

Acta Pharmacologica Sinica 2007年第9期28卷 1476-1493页

作者： Zhenping ZHU Im Clone Systems Incorporated,New York,NY 10014,USA ImClone Systems Incorporated New York USA

Compelling experimental and clinical evidence suggests that epidermal growthfactor receptor (EGFR) plays an important role in the pathogenesis of a variety ofhuman cancers;thus,providing a strong rationale for the development of receptorantagonists as effective and specific therapeutic strategies for the treatment ofEGFR-expressing *** antibodies (mAb),owing to their highspecificity towards a given target,represent a unique class of novel cancertherapeutics.A number of anti-EGFR mAb are currently being developed in ourclinic,including two that have been approved by the United States Food andDrug Administration for the treatment of refractory metastatic colorectal cancer(mCRC) and squamous cell carcinomas of the head and neck (SCCHN).Cetuximab(Erbitux,IMC-C225),an IgG1 mAb,has demonstrated significant antitumor activity,both as a single agent and in combination with chemotherapeutics and radiation,in patients with refractory mCRC and SCCHN,***(Vectibix),an IgG2 mAb,has been approved as a single agent for the treatment ofpatients with refractory *** mAb,via blocking ligand/receptorinteractions,exert their biological activity via multiple mechanisms,includinginhibition of cell cycle progression,potentiation of cell apoptosis,inhibition ofDNA repair,inhibition of angiogenesis,tumor cell invasion and metastasis and,potentially,induction of immunological effector ***-EGFR anti-bodies have demonstrated good safety profiles and potent anticancer activity inour clinic and may prove to be efficacious agents in the treatment of a variety ofhuman malignancies.

关键词： wear particles osteolysis aseptic loosening doxycycline

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：