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全国第十六届大环化学暨第八届超分子化学学术讨论会

作者：尹本涛周成合 School of Chemistry and Chemical Engineering Southwest University

＜正＞Chalcone and its derivatives have been attracting increasingly attention in medicinal agents,optical materials,organic synthesis and molecular ***,chalcone-based supramolecular recognition with infinite potential has been arousing special *** a novel triazolylchalcone 1 was successfully designed and synthesized in 71%yield via Friedel-Crafts acylation,N-alkylation of triazole ring and condensation multi-step procedure starting from 1,*** target compound 1 was

关键词： Chalcone Triazole artificial receptor

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Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging,drug targeting and delivery

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药学学报:英文版 2023年第6期13卷 2736-2746页

作者： Jing Chen Peng Ji Giri Gnawali Mengyang Chang Feng Gao Hang Xu Wei Wang Department of Pharmacology and Toxicology University of ArizonaTucsonAZ 85721USA Department of Chemistry and Biochemistry University of ArizonaTucsonAZ 85721USA BIO5 Institute and University of Arizona Cancer CenterUniversity of ArizonaTucsonAZ 85721USA

The current targeting drug delivery mainly relies on cancer cell surface ***,in many cases,binding affinities between protein receptors and homing ligands is relatively low and the expression level between cancer and normal cells is not *** from conventional targeting strategies,we have developed a general cancer targeting platform by building artificial receptor on cancer cell surface via a chemical remodeling of cell surface glycans.A new tetrazine(Tz)functionalized chemical receptor has been designed and efficiently installed on cancer cell surface as“overexpressed”biomarker through a metabolic glycan *** from the reported bioconjugation for drug targeting,the tetrazine labeled cancer cells not only locally activate TCO-caged prodrugs but also release active drugs via the unique bioorthogonal Tz-TCO click-release *** studies have demonstrated that the new drug targeting strategy enables local activation of prodrug,which ultimately leads to effective and safe cancer therapy.

关键词： artificial receptor Click and release Local activation Protein degradation

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Synthesis of a pair of novel receptors and their properties of enantioselective recognition for amino acid zwitterions

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Chinese Journal of Chemistry 1999年第5期17卷 508-515,427页

作者：陆国元刘芳何卫江王志林胡宏纹 Department of Chemistry Nanjing University Nanjing Jiangsu 210)93 China Departament de Quimica Organica Universidad Autonoma de Madrid Madrid 28049 Spain

A pair of artificial enantiotopic receptors la and lb composed of (S,S) or (R,R) chiral bicyclic guanidinium, azacrown ether and (t-butyldiphenylsilyloxy) methyl group for amino acid zwitterions have been synthesized. The liquid-liquid competition experiments and 1 H NMR studies indicate that the receptor 1a with (S, S) configuration and 1b with (R,R) configuration selectively recognize L- and D-aromatic amino acids & respectively.

关键词： Enantioselective Recognition amino acid zwitterions artificial receptor

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Benzimidazole artificial Ion receptors:Synthesis and Application

Benzimidazole Artificial Ion Receptors:Synthesis and Applica...

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全国第十七届大环化学暨第九届超分子化学学术研讨会

作者：房雪洁彭莘媚 Guri L V Damu Kannekanti Vijava Kumar 周成合 Schoolof Chemistry and Chemical Engineering Southwest University Indian Institute of Chemical Technology(IICT) School of Chemistry and Chemical Engineering Southwest University

＜正＞Cationic and anionic charged species are ubiquitous in chemical,biological,medical,environmental,and industrial *** in human body,the importance of biologically relevant ions can not be underestimated for the fa... 详细信息

关键词： Benzimidazole Metal Supraniolecular Recognition artificial receptor

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