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Nanofibrous nerve conduits for repair of 30-mm-long sciatic nerve defects

Neural Regeneration Research 2013年第24期8卷 2266-2274页

作者： Esmaeil Biazar Saeed Heidari Keshel Majid Pouya Hadi Rad Melody Omrani Nava Mohammad Azarbakhsh Shirin Hooshmand Department of Biomaterial Engineering Tonekabon Branch Islamic Azad University Student Research Committee Proteomics Research Center Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Department of Tissue Engineering School of Advanced Technologies in Medicine Tehran University of Medical Sciences Department of Medical Sciences Tonekabon Branch Islamic Azad University Faculty of Medical Sciences Babol University of Medical Sciences

It has been confirmed that nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） nerve conduit can promote peripheral nerve regeneration in rats. However, its efficiency in repair of over 30-mm-long sciatic nerve defects needs to be assessed. In this study, we used a nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） nerve conduit to bridge a 30-mm-long gap in the rat sciatic nerve. At 4 months after nerve conduit implantation, regenerated nerves were macroscopi- cally observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber. There were Schwann cells and glial cells in the regenerated nerves. Masson＇s trichrome staining showed that there were no pathological changes in the size and structure of gastrocnemius muscle cells on the operated side of rats. These findings suggest that nanofibrous poly（3-hydroxybutyrate-co-3- hydroxyvalerate） nerve conduit is suitable for repair of long-segment sciatic nerve defects.

关键词： neural regeneration peripheral nerve injury sciatic nerve artificial conduit nanofiber poly(3-hydr-oxybutyrate-co-3-hydroxyvalerate) macroscopic observation histology grants-supported paper neuroregeneration

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